History Main / HybridizationPlot

* ''Series/TheVampireDiaries'': Klaus Mikaelson, the BigBad of season 2, is both an Original Vampire (one of the progenitors of the Vampire species) and a Werewolf, making him the first example of a Hybrid in the franchise. His main goal in the season is the creation of more Hybrids like himself, though it is implied that this is due to his own loneliness from his status as the only Hybrid.

* ''Franchise/FullMetalAlchemist'': One of the more advanced forms of alchemy being actively studied is that of hybridizing creatures to form chimera. The foremost alchemist in the field is one Shou Tucker, who was able to create one that was intelligent enough to talk. [[spoiler:It is later revealed that, in his desperation to gain his alchemist license, he violated taboo once, and fused his ''wife'' into said talking chimera. She ultimately commits suicide by refusing to eat and starving to death]]. When [[spoiler:his license is once again threatened due to his lack of progress with other talking chimera, he fuses his ''daughter'' with her dog to create another]].
* ''Franchise/{{Bleach}}'': this turns out to be the secret backstory and origin of [[spoiler:Ichigo, the protagonist.]] Each major race of the setting -- Shinigami, Hollow, Fullbringer, and Quincy -- has hard limits on how powerful they can become and the nature of powers they can wield - but a hybrid has the potential of both parent races, and a hybrid of all four, as [[spoiler:Ichigo]] ends up being, has no limits to how strong he can get or the kinds of power he could wield. [[spoiler:It’s explicitly stated that Ichigo’s conception and birth were manipulated in order to produce a potential heir for the Soul King, A.K.A. God.]]

* ''Film/{{Underworld 2003}}'': A major plot point in the franchise, considering the fact that hybrids there tend to run on HybridPower:
** In the original movie, the major reason why the Lycans want Michael is that being a direct descendant of the common ancestor between the [[OurWerewolvesAreDifferent Lycans]] and Vampires, he is the only person capable of becoming a Lycan-Vampire hybrid, which they intend to weaponize to kill off the vampire leadership.
** In ''Evolution'', Marcus wanted to turn his werewolf brother William into a hybrid in an attempt to restore his humanity, with plans as well to create a new race of hybrids to rule over alongside his brother, although he is killed before he could do so.
* ''Film/JurassicWorld'' centers in the creation of a hybrid super predator that escapes and wreaks havoc in the park. It was actually an attempt to make weaponized dinosaurs for the military.
* Continued in ''Film/JurassicWorldFallenKingdom'' where the ''Indoraptor'' was created as an improved prototype. It, too, got loose and stalked the humans around a rich guy’s mansion.

* In ''Literature/AMillionAdventures'', one of the chapters in the RandomEventsPlot first part focuses on Pashka trying to create a mosquito/goose hybrid so that mosquitoes would become migratory. His attempt results in a ferocious goose-sized mosquito that tries to attack the children and animals at the research station and [[spoiler:is killed by Heracles before anyone can learn if it inherited the migratory instinct from geese]].

* ''Series/EarthFinalConflict'' had an episode with intentional producing of Atavus hybrids. Rene’s boyfriend is badly hurt trying to shut down the production facility and she makes a last ditch effort to save him by hybridizing him. Sadly, his body rejects the [=DNA=] and he dies.

* Seamus Kennedy's offbeat song [[https://www.youtube.com/watch?v=IQc_zN9y-tY Iditarod]] recounts his fictional effort to assemble a sled dog team of huskies hybridized with a veritable zoo of creatures to compete in the famous real-world endurance race in Alaska.

* ''VideoGame/FinalFantasyVII''
** The main idea behind the Jenova Project is to create human-Cetra [[spoiler:or human-Jenova, to those in the know]] hybrids. The goal was to use the hybrids to help lead them to ThePromisedLand, which was said to be abundant in Mako.
** Early in the game [[MadScientist Hojo]] attempted to breed Aerith with Red XIII to create a research subject with Aerith's Cetra powers and Red XIII's [[LongLived lifespan]]. No one is entirely sure how Hojo thought this would work between a human woman and a sapient but non-anthropomorphic wolf.
** Due to the FridgeLogic of Hojo's attempt to crossbreed Aerith with Red XIII, ''VideoGame/FinalFantasyVIIRemake'' instead has Hojo plan to forcibly breed Aerith with SOLDIER members to create [=SOLDIERs=] with Cetra powers. He even briefly considers forcing Aerith to have children with [[BigBad Sephiroth]], [[spoiler: and talks in a disturbingly dehumanizing way about his own hypothetical grandchildren.]]

* ''VideoGame/StarcraftII'': In VideoGame/LegacyOfTheVoid, it's revealed Amon plans to ravage the galaxy with his Protoss/Zerg hybrids, massively powerful creatures combining the Zerg's physical adaptations with the PsychicPowers of the Protoss. The Tal'darim are a RenegadeSplinterFaction of Protoss willingly working for Amon [[WorkingForABodyUpgrade in the hopes of being similarly uplifted...]] [[spoiler:until they learn the hybrids are lab-grown so they can't become hybrids, at which point they defect and work with the heroes as the TokenEvilTeammate]].
* ''VideoGame/XenobladeChronicles'': The High Entia have been purposely having children with Homs for centuries in order to eventually [[spoiler:breed the curse of being forcibly transformed into Telethia out of the species]], Princess Melia Antiqua being one such example. It's only because of this that the High Entia as a people manage to survive upon Zanza's revival, as only those High Entia with Homs ancestry avoid sharing the fate of their full-blooded fellows of [[spoiler:being forcibly transformed into Telethia.]]

** In ''WesternAnimation/Ben10AlienForce'' the Highbreed are dying out from inbreeding due to their xenophobic isolationism, and intend to take out the rest of the universe with them, [[spoiler:so Ben uses the Omnitrix to transform their entire species into hybrids of assorted species.]]

* ''WebOriginal/HamstersParadise'': After the more technologically advanced tundra harmsters are able to use superior weapons and tactics to subjugate their more primitive relatives, the savannah and matriarch harmsters (and outright eradicate the [[MySpeciesDothProtestTooMuch peaceful]] mountain harmster) they are still able to recognize the physical advantages they possess and forcibly breed with their captives to gain better adaptability and strength. To add insult to injury, they selectively breed them into [[FormerlySapientSpecies non-sapient animals]] afterward.

* ''EarthFinalConflict'' had an episode with intentional producing of Atavus hybrids. Rene’s boyfriend is badly hurt trying to shut down the production facility and she makes a last ditch effort to save him by hybridizing him. Sadly, his body rejects the [=DNA=] and he dies.

* Seamus Kennedy's offbeat song "Iditarod" recounts his fictional effort to assemble a sled dog team of huskies hybridized with a veritable zoo of creatures to compete in the famous real-world endurance race in Alaska.

* ''VideoGame/FinalFantasyVII'''

* ''Film/{{Underworld}}'': A major plot point in the franchise, considering the fact that hybrids there tend to run on HybridPower:

* The main idea behind ''VideoGame/FinalFantasyVII'''s Jenova Project is to create human-Cetra [[spoiler:or human-Jenova, to those in the know]] hybrids. The goal was to use the hybrids to help lead them to ThePromisedLand, which was said to be abundant in Mako.

We all know that the HalfHumanHybrid and the NonHumanHumanoidHybrid tend to have [[HybridPower all of the strengths of their parents, and none of their disadvantages]]. Well, sometimes a character is GenreSavvy, and catches on to this.

* ''Franchise/{{Bleach}}'': this turns out to be the secret backstory and origin of [[spoiler:Ichigo, the protagonist.]] Each major race of the setting: Shinigami, Hollow, Fullbringer and Quincy, has hard limits on how powerful they can become and the nature of powers they can wield - but a hybrid has the potential of both parent races, and a hybrid of all four, as [[spoiler:Ichigo]] ends up being, has no limits to how strong he can get or the kinds of power he could wield. [[spoiler:It’s explicitly stated that Ichigo’s conception and birth was manipulated in order to produce a potential heir for the Soul King, A.K.A. God.]]

* In ''Literature/AMillionAdventures'', one of the chapters in the RandomEventsPlot first part focuses on Pashka trying to create a mosquito/goose hybrid so that mosquitoes would become migratory. His attempt results in a ferocious goose-sized mosquito which tries to attack the children and animals at the research station and [[spoiler:is killed by Heracles before anyone can learn if it inherited the migratory instinct from geese]].

* ''Series/TheXFiles'': A large part of the series revolves around the Syndicate working to produce successful hybrids of human and alien DNA (theoretically to produce a slave race to work under the aliens after they colonize Earth, but covertly to develop a vaccine against the aliens' ability to infect humans). Their methods include gene therapy, cloning, or conceiving via a hybridization process. The results vary in wild ways; some hybrids (like the Samantha Mulder clones) are indistinguishable from human, while others can develop both mental instability and preternatural abilities.

* Seamus Kennedy's offbeat song "Iditarod" recounts his fictional effort to assemble a sled dog team of huskies hybridized with a veritable zoo of creatures to compete in the famous real world endurance race in Alaska.

* ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'': Baron Draxum's goal is to use his oozesquitoes to mutate all of humanity into mutant animal hybrids in a bid to save the Yokai. This results in newly mutated humans wrecking havoc across New York as many turn to crime. The Turtles were all subject to his experiments and Draxum points out that without him, they would not have existed as they do now.

* ''WesternAnimation/SpongeBobSquarePants'': In "[[Recap/SpongeBobSquarePantsS12E7TheKrustyBucketSquidsOnABus The Krusty Bucket]]", Plankton creates a hybrid clone from his and Mr. Krabs' DNA in yet another attempt to get the secret formula for the Krabby Patty. The resulting clone, [=PlanKrab=], has Krabs' business sense and Plankton's intelligence and is able to quickly take over the Krusty Krab and win over even [=SpongeBob=] and Squidward. However, he now has no need for Plankton, and kicks him out of the restaurant. Krabs and Plankton then have to team up to get rid of [=PlanKrab=] and his new business.
* ''WesternAnimation/TransformersAnimated'': Prometheus Black's biotechnology company was constantly outperformed by Isaac Sumdac's robotics, and when a last ditch attempt to sell his technology as a viable alternative failed he went into a rage and accidentally turned himself into the supervillain Meltdown. When he next appears, he's gotten it into his head that biotechnological hybrids might be powerful enough to battle even the likes of the Autobots, and demonstrates with a fish monster and a bat monster created from two of [[YouHaveOutlivedYourUsefulness his former employees]]. He intends to create even more, but is stopped by the Autobots and police captain Fanzone.

* ''Franchise/Bleach'': this turns out to be the secret backstory and origin of [[spoiler:Ichigo, the protagonist.]] Each major race of the setting: Shinigami, Hollow, Fullbringer and Quincy, has hard limits on how powerful they can become and the nature of powers they can wield - but a hybrid has the potential of both parent races, and a hybrid of all four, as [[spoiler:Ichigo]] ends up being, has no limits to how strong he can get or the kinds of power he could wield. [[spoiler:It’s explicitly stated that Ichigo’s conception and birth was manipulated in order to produce a potential heir for the Soul King, A.K.A. God.]]

* ''Franchise/Bleach'': this turns out to be the secret backstory and origin of [[spoiler:Ichigo, the protagonist.]] Each major race of the setting: Shinigami, Hollow, Fullbringer and Quincy, has hard limits on how powerful they can become and the nature of powers they can wield - but a hybrid has the potential of both parent races, and a hybrid of all four, as [[spoiler:Ichigo]] ends up being, has no limits to how strong he can get or the kinds of power he could wield.

* ''Series/StarTrekEnterprise'': One two-episode arc towards the end of the series involves [[FantasticRacism anti-alien extremists]] stealing the DNA of Trip (a human) and T'Pol (an alien; specifically a Vulcan) to make a cross-breed baby girl, who they name Elizabeth. The extremists cite Elizabeth as the kind of thing that will happen if aliens interact with humans and therefore as a reason why they shouldn't.

Of course, this can backfire - in some cases, the hybrid [[HybridsAreACrapshoot may inherit the worst parts of each parent, and flounder as a result]].

[[folder:Film -- Live-Action]]

** The motive of the Cult of Skaro in "[[Recap/DoctorWhoS29E4DaleksInManhattan Daleks In Manhattan]]/[[Recap/DoctorWhoS29E5EvolutionOfTheDaleks Evolution of the Daleks]]" - Dalek Sec in particular wants to become a Human/Dalek hybrid, both in a last-ditch attempt to keep the Dalek race alive and in an attempt to harvest humanity's hatred, ambition, and propensity for war. However, HumanityIsInfectious, and he instead decides to create a new race of Dalek-Humans so that the Dalek race can rebuild themselves as a race of pacifists instead of the Space-Nazis they normally are. Too bad the other three, who wanted to put Dalek minds inside human bodies to TakeOverTheWorld instead, don't appreciate this.

* The main idea behind ''VideoGame/FinalFantasyVII'''s Jenova Project is to create human-Cetra [[spoiler: or human-Jenova, to those in the know]] hybrids. The goal was to use the hybrids to help lead them to ThePromisedLand, which was said to be abundant in Mako.

[[folder:Web Originals]]

** In ''WesternAnimation/Ben10AlienForce'' the Highbreed are dying out from inbreeding due to their xenophobic isolationism, and intend to take out the rest of the universe with them, [[spoiler: so Ben uses the Omnitrix to transform their entire species into hybrids of assorted species.]]
** During ''WesternAnimation/Ben10UltimateAlien'', a group of human/alien hybrids are introduced called the Amalgam kids. However, although they had initially been presented as coming from several [[InterspeciesRomance Interspecies Romances]], ''WesternAnimation/Ben10Omniverse'' [[{{Retcon}} gives a different explanation for their hybrid states]] - they were originally normal children until Servantis used Kevin's powers on them to turn them into human/alien hybrids, mainly under the belief that it was one of the only ways to stop Ben from destroying the universe.

* ''WesternAnimation/TheSimpsons'': When Bart finds out that the teleportation machine that Homer bought in "[[Recap/TheSimpsonsS9E4TreehouseOfHorrorVIII Treehouse of Horror VIII]]" is capable of creating multiple hybrids between two different creatures, he tries to become a human/fly hybrid under the belief that it would turn him into a superhero. It doesn't work - he comes out as a normal-sized fly with his head on it, whilst the fly comes out as Bart's body with a fly head on.

* Parodied in the ''WesternAnimation/{{Futurama}}'' episode [[Recap/FuturamaS3E19RoswellThatEndsWell Roswell That Ends Well]] when [[UsefulNotes/HarrySTruman President Truman]] asks Zoidberg if he's on Earth to create a human-alien hybrid, which Zoidberg interprets as coming onto him.

* ''Anime/FullMetalAlchemist'' (both 2003 and modern series): One of the more advanced forms of alchemy being actively studied is that of hybridizing creatures to form chimera. The foremost alchemist in the field is one Shou Tucker, who was able to create one that was intelligent enough to talk. [[spoiler:It is later revealed that, in his desperation to gain his alchemist license, he violated taboo once, and fused his ''wife'' into said talking chimera. She ultimately commits suicide by refusing to eat and starving to death]]. When [[spoiler:his license is once again threatened due to his lack of progress with other talking chimera, he fuses his ''daughter'' with her dog to create another]].

* Parodied in the ''WesternAnimation/{{Futurama}}'' episode [[Recap/FuturamaS3E19RoswellThatEndsWell Roswell That Ends Well]] when President Truman asks Zoidberg if he's on Earth to create a human-alien hybrid, which Zoidberg interprets as coming onto him.

* Many alien abductees report being subjected to breeding experiments by their captors. Some speculate that TheGrays are suffering from CloneDegeneration and are resorting to hybridization with humanity to refresh their gene pool, while others fear that they are breeding an army to invade Earth.

* ''Franchise/Ben10'': During ''WesternAnimation/Ben10UltimateAlien'', a group of human/alien hybrids are introduced called the Amalgam kids. However, although they had initially been presented as coming from several [[InterspeciesRomance Interspecies Romances]], ''WesternAnimation/Ben10Omniverse'' [[{{Retcon}} gives a different explanation for their hybrid states]] - they were originally normal children until Servantis used Kevin's powers on them to turn them into human/alien hybrids, mainly under the belief that it was one of the only ways to stop Ben from destroying the universe.

* ''Anime/FullMetalAlchemist'' (both 2003 and modern series): One of the more advanced forms of alchemy being actively studied is that of hybridizing creatures to form chimera. The foremost alchemist in the field is one Shou Tucker, who was able to create one that was intelligent enough to talk. [[spoiler:It is later revealed that, in his desperation to gain his alchemist license, he violated taboo once, and fused his ''wife'' into said talking chimera. She ultimately commits suicide by refusing to eat and starving to death]]. When [[spoiler:his license is once again threatened due to his lack of progress with other talking chimera, he fuses his ''daughter' with her dog to create another]].

* ''Anime/FullMetalAlchemist'' (both 2003 and modern series): One of the more advised forms of alchemy being actively studied is that of hybridizing creatures to form chimera. The foremost alchemist in the field is one Shou Tucker, who was able to create one that was intelligent enough to talk. [[spoiler:It is later revealed that, in his desperation to gain his alchemist license, he violated taboo once, and fused his ''wife'' into said talking chimera. She ultimately commits suicide by refusing to eat and starving to death]]. When [[spoiler:his license is once again threatened due to his lack of progress with other talking chimera, he fuses his ''daughter' with her dog to create another]].

* ''Anime/FullMetalAlchemist'' (both 2003 and modern series): One if the more advices forms of alchemy being actively studied is that of hybridising creatures to form chimaera. The foremost alchemist in the field is one Shou Tucker, who was able to create one that was intelligent enough to talk. [[spoiler:It is later revealed that, in his desperation to gain his alchemist licence, he violated taboo once, and fused his ''wife'' into said talking chimaera. She ultimately commits suicide by refusing to eat and starving to death]]. When [[spoiler:his licence is once again threatened due to his lack of progress with other talking chimera, he fuses his ''daughter' with her dog to create another]].