History Main / FictionalDisability

* Seteth and Flayn from ''VideoGame/FireEmblemThreeHouses'' qualify for the "fantastic condition" category. [[spoiler:They're part of the Nabatean race, people who can normally transform into draconic forms. Neither of them have their dragon forms shown on-screen though, unlike Rhea (who is shown transforming in both the ''Crimson Flower'' and ''Silver Snow'' routes) or Indech and Macuil (who are only ever seen in their dragon forms). Seteth specifically mentions having "lost" his ability to transform, while Flayn suffered heavy injuries that caused her to sleep for several hundred years to heal. Presumably, they both suffered some kind of physical damage that keeps them from transforming.]] While they have few difficulties with things most normal people do, [[spoiler:they're both permanently locked out of an ability that most of their species has]].

* ''Manga/DeliciousInDungeon'': [[spoiler:The Captain of the Canaries, Mithrun]], is extremely absent-minded due to having all his bodily desires eaten by a demon after being trapped in a LotusEaterMachine, leaving only a burning desire to destroy all demons. As a result, he often forgets to eat, sleep, or go to the bathroom unless repeatedly prompted, or will otherwise just keep going until he collapses from exhaustion. In fact, he ''can't'' sleep normally and has to be coaxed via relaxation techniques such as a spell, medication, or a massage. On top of that, he also has no depth perception, due to having [[EyeScream an eye gouged out]] by the same demon, and a ridiculously bad sense of direction.

* In ''Film/Skins2017'', a movie about deformed people, one of the plots revolves around a woman named Samantha who has an anus for a mouth and a mouth for an anus. While the rest of the characters have realistic disabilities, hers stands out as being the only fantastical one.

* In the Creator/{{Marvel}} universe there are some Skrulls born without the ability to shapeshift like the rest of their species.

* ''Literature/SwordArtOnline'' includes a condition called [="FullDive Non-Conformity"=], where someone is unable to play thought-controlled {{Cyberspace}} games properly due to unusual brain structure. In most cases this results in dulled sensory feedback or unusually high lag, but in one case (Eiji from the movie ''[[Anime/SwordArtOnlineTheMovieOrdinalScale Ordinal Scale]]'') it had the unusual effect of misinterpreting any fear in his mind as a command, causing his avatar to become paralysed in even mildly tense situations. This is used to explain how someone with as much real-life fighting skill as Eiji never made a name for himself in the ''SAO'' death game. The AnimatedAdaptation of the books' ''War of the Underworld'' arc includes a {{Filler}} episode where Eiji returns and somehow manages to overcome his brain structure through HeroicWillpower in a ([[ShaggyDogStory failed]]) stand against TheDragon of the arc.
** Notably, [=FDNC=] is portrayed as the low end of a scale rather than an either-or condition - characters like Kirito and Yuuki are noted to be exceptional fighters because of their unusually ''high'' compatibility with the technology, and in the DistantSequel ''Literature/AccelWorld'' the underground game "Brain Burst" requires a well above-normal [=FullDive=] conformity rating to even install.

* The ''Literature/VorkosiganSaga'': Vorzohn's Dystrophy, a hereditary degenerative disorder on the planet Barrayar (which presumably developed on that planet in the centuries since it was settled) plays a significant role in ''Komarr''. Barrayar is a world where "mutants" of any kind are hated and feared. The character Tien Vorsoisson's failures in dealing with his own condition (and that of his son, Nikki) wind up driving events that change the life of the series protagonist, Miles Vorkosigan, in a very important way, since [[spoiler:Miles later winds up marrying Tien's widow Ekatarin and becoming stepfather to Nikki Vorsoisson, after Tien dies (albeit not directly of Vorzohn's Dystrophy, but Tien's desperation to treat his condition in total secrecy drives his actions which lead to his death)]].

* Philza from the ''LetsPlay/DreamSMP'' is a WingedHumanoid whose wings got destroyed by shrapnel after he [[WingShield used them as a shield]] to protect himself and Wilbur from the explosion of L'Manburg. He still has them, but they're so damaged that he'll never be able to fly with them again.

* Atsuko "Akko" Kagari in ''Anime/LittleWitchAcademia2017'' is already heavily coded as having ADHD, but it later turns out that this is not the only disability she suffers that prevents her from learning magic at the same rate as her peers. [[spoiler:As a child, her magic was drained by Croix' dream fuel spirit, which stunted her magical potential. While this can be overcome through hard training and practice, as seen with Diana who was stunted in the same way but recovered, Akko has never had the support or means to practice magic until she attended Luna Nova, meaning that she had no way to deal with her disability or even learn that she had one]].
* ''Manga/MyHeroAcademia'': 20 percent of the human population is born [[UnSorcerer Quirkless]], meaning that they [[MuggleBornOfMages don't possess any kind of superpowers]]. For people like protagonist Izuku Midoriya, this can be humiliating and the source of scorn and bullying, especially since he wants to become a superhero more than anything. Luckily for him, his sheer heroic spirit and willingness to throw himself into danger for the sake of others inspires his idol, All Might, to [[SuperEmpowering pass down his unique Quirk to him.]]
* ''Manga/{{Naruto}}'': Rock Lee is congenitally incapable of ninjutsu or genjutsu ([[MagicByAnyOtherName i.e. magic]]), leaving him with just taijutsu (martial arts). This forces him into a WhenAllYouHaveIsAHammer approach to being a ninja, and means he has to [[HardWorkHardlyWorks work much harder just to be a competitive second-string fighter]] in a world of [[SuperpowerfulGenetics aristocratic bloodlines with inherited superpowers]] and [[PoweredByAForsakenChild bound monsters used by ninjas as batteries]].

* ''Manga/SheBecomesATree'': Kisaki has Woodman Syndrome, which causes her to be able to sprout tree limbs out of her body. [[CursedWithAwesome These limbs are strong and flexible]], enabling her to retrieve a classmate's shoes from a tall tree, and to work several times as fast as a normal person as an adult OfficeLady, but they're difficult to control, and result in people [[AllOfTheOtherReindeer ostracizing Kisaki]].

* ''ComicBook/Transformers2019'' treats being an Action Master (a transformer unable to transform into vehicle mode) as a disability, particularly in ''Wreckers: Treads and Circuits'' which is set on vehicle centric Velocitron.

** In Creator/Kilala97's next generation setting, Alto Trot is a pegasus who was born without wings, and was thought to have been born an earth pony until he climbed onto a cloud his mother was using to water her plants. Although his magic is still pegasus rather than earth pony magic, allowing him to walk on and shape clouds like any other pegasus, he's unable to leave the ground unless he's carried up or able to climb onto a low-hanging cloud.

*** In [[Recap/TriptychContinuumScootalift Scootalift]], Snowflake diagnoses Scootaloo with being a slow or late developer, so she will take longer than other pegasi to be able to fly.

** Equestria is a FictionalCountry in which the population is prone to a disability which makes it very hard to conceive and carry boy babies to term, meaning women outnumber men, and Twilight is chosen as the future ruler partly because she might be able to have a healthy son.

* ''WesternAnimation/HappyFeet:'' Mumble's egg was dropped before he hatched. This [[MST3KMantra somehow]] resulted in him not being able to sing like all the other penguins, so he tap-dances instead.
* ''WesternAnimation/{{How to Train Your Dragon|2010}}'': Toothless lost part of his tail fin after being shot out the sky by Hiccup. He can't fly on his own anymore, so Hiccup invents a fake fin that he can manipulate so they can fly together. In the [[WesternAnimation/HowToTrainYourDragonTheHiddenWorld 3rd film]], Hiccup [[spoiler:makes another that Toothless can use on his own, so he no longer needs Hiccup to fly]].

* ''[[Literature/TheShadowFairyTale The Shadow]]'': Parodied with the Princess. She is at a health resort because of her disease of "being too sharp-sighted, which made every one very uneasy".

* ''Series/DirkGentlysHolisticDetectiveAgency'': Siblings Amanda and Todd Brotzman suffering from Pararibulities; a hereditary condition that causes vivid hallucinations with real physical pain.

* ''TabletopGame/{{Warhammer}}'': Teclis is the greatest mage the Elves have ever produced, and one of the greatest mages in world history. He is also a ''ridiculously'' SquishyWizard and very physically frail, requiring daily healing potions to be more than bedridden, and having a limp incurable by magic. By contrast, his brother Tyrion is a peerless swordmaster.

* In ''VideoGame/AdventureWelcomeToTheGenre'', the protagonist Thalia James gets a rare disease which causes her to temporarily switch identities with the nearest living organism with a central nervous system. However, she manages to gain control of it, making it a DisabilitySuperpower.

** ''Morrowind'' and ''Oblivion'' have "Stunted Magicka", a condition which prevents people from regenerating their Magicka reserves naturally. This instead forces them to absorb it from outside sources. It can be congenital, notably for those born under the Atronach [[FictionalZodiac star sign]], but can also be inflicted by a magical disease.

** Most people in the setting are able to manipulate the aether in their own bodies to perform feats of magic, provided they have sufficient training. However, there are some who born with such low reserves of aether that it's impossible for them to cast even the simplest spells. There are others who have, either from birth or from a magical accident, lost the ability to manipulate aether altogether, rendering them incapable of utilizing any technology requiring the application of aether, such as aetherytes.
** Much like how people can get motion sick in real life, some people suffer from acute aether sickness, meaning that trying to transport themselves with an aetheryte will lead to nausea, vomiting, and dizzyness. Professor T'laqua Tia in Sharlayan suffers from this, requiring the aid of an adept angler to help him complete his thesis on time because he can't attune to an aetheryte without collapsing. This can also be briefly induced unto others through the use of experimental aetherytes. After taking one such aetheryte to Thavnair, the Warrior, Thancred, and Urianger all fight to keep their lunch down.

* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler:until he traveled to the Rewind Spring, where Pandora revived herself from said powers]].

** Bastion has a robotic analogue to PTSD, in that [[TraumaButton anything that reminds it]] of the [[RobotWar Omnic Crisis]] causes it to revert to its KillerRobot programming (notably in the "The Last Bastion" short, the machine-gun-like sound of a woodpecker causes it to panic and destroy a large number of trees with its minigun). Slightly different from PTSD in humans, in that it's caused by what remains of Bastion's original programming, rather than a trauma induced trigger.

** Downplayed with Scootaloo: She's a pegasus filly who can't fly, even though her classmates can. For most of the series it was ambiguous whether Scootaloo is permanently disabled or just a late bloomer,[[note]]At one point, Lauren Faust herself stated that Scootaloo "hadn't figured it out yet".[[/note]] although in all episodes addressing the issue it's been clear that she cannot at present fly and that this is fairly abnormal for a pegasus her age. "Growing Up is Hard to Do" shows her adult body with child-size wings, and a few days later one of the staff [[DiagnosisOfGod stated that this was in fact meant to indicate an actual disability]]. But even that included the line "fans are welcome to interpret things how they like" (given that Bulk Biceps can fly despite having even smaller wings, Scootaloo's situation is still technically open to interpretation).

* ''WesternAnimation/StevenUniverse'': Gems are artificially created for specific purposes in their HiveCasteSystem. At times, however, the circumstances of their "birth" leave them with various defects of deformities, giving them different body-types and even differences in their powers, abilities, and mindsets. These types of gems are referred to as "Off-Color". Due to the gems' strict caste system, these are usually discarded, persecuted, and even exterminated.
** Amethysts are quartz gems designed to be tall, buff intimidating soldiers. Amethyst from the Crystal Gems however did not finish forming until long after the others (she was "overcooked", in Jasper's words), coming out just barely half the height of what an amethyst should be. Additionally, while a gem will typically be BornAsAnAdult both physically and mentally (even having knowledge of their Homeworld and specific purpose), Amethyst was a BlankSlate who had to learn things like an infant would.

** Peridot is an Era 2 peridot created under an environment where resources in creating gems on Homeworld have dwindled. This why Peridot lacks many of the powers associated with gems (shapeshifting, super strength, etc.) and may account for her short stature. To compensate, era 2 peridots are equipped with technological limb enhancers. [[spoiler: Although it turns out that Peridot, at least, also has [[ExtraOreDinary ferrokinetic powers]].]]

** The Rutile twins' gemstone started developing into two different directions, giving them a torso that springs into two prongs, each with a head on it. Unlike human ConjoinedTwins, this seems to make them ''literally'' SingleMindedTwins.

* ''Series/DirkGentlysHolisticDetectiveAgency'': Siblings Amanda and Todd Brotzman suffering from Pararibulities; a hereditary condition that causes vivid hallucinations with real physical pain. It is considered a real condition InUniverse.

* The ''Literature/VorkosiganSaga'': Vorzohn's Dystrophy, a fictional hereditary degenerative disorder on the planet Barrayar (which presumably developed on that planet in the centuries since it was settled) plays a significant role in ''Komarr''. Barrayar is a world where "mutants" of any kind are hated and feared. The character Tien Vorsoisson's failures in dealing with his own condition (and that of his son, Nikki) wind up driving events that change the life of the series protagonist, Miles Vorkosigan, in a very important way, since [[spoiler:Miles later winds up marrying Tien's widow Ekatarin and becoming stepfather to Nikki Vorsoisson, after Tien dies (albeit not directly of Vorzohn's Dystrophy, but Tien's desperation to treat his condition in total secrecy drives his actions which lead to his death)]].

* ''WesternAnimation/HowToTrainYourDragon'': Toothless lost part of his tail fin after being shot out the sky by Hiccup. He can't fly on his own anymore, so Hiccup invents a fake fin that he can manipulate so they can fly together. In the 3rd film, Hiccup [[spoiler:makes another that Toothless can use on his own, so he no longer needs Hiccup to fly]].

* In ''Fanfic/WithPearlAndRubyGlowing'', [[WesternAnimation/RayaAndTheLastDragon DRUUN]] (Deposit-Rich Un-Uniform Neomineralization) is a horrible disease that causes mineral stones to form throughout the body due to it no longer being able to break down calcium.

* In the Marvel universe there are some Skrulls born without the ability to shapeshift like the rest of their species.

* ''Fanfic/{{Eleutherophobia}}'': Ex-hosts frequently have a disorder called Post-Infestation Affective Blunting Syndrome. Due to not being able to use their own bodies for so long, their brains lose the ability to perform automatic actions. They rarely make facial expressions, have uncoordinated movements and slurred speech, and take a while to respond to outside stimuli.

* ''WesternAnimation/MyLittlePonyTheMovie2017'': Tempest Shadow has a broken horn as a result of an accident as a filly. While it doesn't negate her ability to use magic entirely, she is unable to use even basic skills such as telekinesis and can only release her magic as an uncontrolled, destructive torrent of energy.[[note]]Her subsequent appearances in the IDW comic have her using telekinesis, but with a very different aura than a unicorn with an intact horn.[[/note]]

** In ''The Other'', an Andalite named Mertil suffers from a condition that makes him unable to use the morphing technology, and his friend Gafinilan suffers from a painful disease known as Soola's Disease, which can only be gotten rid of by acquiring and morphing another Andalite permanently (also making him unable to use morphing technology). Ax's reaction to the ''vecol'' makes it a stand-in for AIDS.
** In ''The Proposal'', Marco's emotional issues revolving around his dad deciding to marry his math teacher causes him to morph into freakish animal hybrids, such as a salmon with gorilla arms or a skunk/spider hybrid. Similarly, he gets better by the end.
* ''Literature/ATaleOf'': Maleficent is a fairy who was born with no wings. This, along with her unusual appearance, causes other fairies to wonder if she's even a fairy at all.

* ''Literature/MushokuTensei'': Travelling mage Roxie is revealed via FlashBack to be a rare "deaf-mute" member of a tribe of telepaths, who can hear the language of her people only as a meaningless pop in her mind. Roxie's parents went out of their way to prevent her from realising that she was disabled for as long as possible, which included teaching themselves spoken language and keeping Roxie away from other children.

* ''Literature/SwordArtOnline'' includes a condition called [="FullDive Non-Conformity"=], where someone is unable to play thought-controlled VirtualReality games properly due to unusual brain structure. In most cases this results in dulled sensory feedback or unusually high lag, but in one case (Eiji from the movie ''[[Anime/SwordArtOnlineTheMovieOrdinalScale Ordinal Scale]]'') it had the unusual effect of misinterpreting any fear in his mind as a command, causing his avatar to become paralysed in even mildly tense situations. This is used to explain how someone with as much real-life fighting skill as Eiji never made a name for himself in the ''SAO'' death game. The AnimatedAdaptation of the books' ''War of the Underworld'' arc includes a {{Filler}} episode where Eiji returns and somehow manages to overcome his brain structure through HeroicWillpower in a ([[ShaggyDogStory failed]]) stand against TheDragon of the arc.

* ''Series/DirkGentlysHolisticDetectiveAgency'': Siblings Amanda and Todd Brotzman suffering from Pararibulities; a hereditary condition that causes vivid hallucinations with real physical pain. It is considered a real condition InUniverse.

* ''VideoGame/SonicTheHedgehog'': Maria Robotnik was dying from Neuro-Immune Deficiency Syndrome (NIDS), though her actual death was caused by being shot. NIDS weakens both the nervous and immune systems, and has similar side effects to AIDS. In Japan, NIDS is described as a "primary immunodeficiency" disorder and a "hereditary immune deficiency syndrome", which are both real diagnoses, but NIDS itself is fictional.

* ''WebOriginal/SeventeenThousandSevenHundredSeventySix'': As the oldest of the space probes that have gained sentience, Nine is limited by their battery, and can only awaken for a few weeks before needing to recharge.
* ''Literature/WhateleyUniverse'': Roulette gets occasional burnouts, which is where the body cooks itself due to overuse of its mutant powers every once in a while, and each one changes her powers.

* ''WesternAnimation/TheSimpsons'': In "[[Recap/TheSimpsonsS2E22BloodFeud Blood Feud]]", Mr. Burns falls ill with a medical condition called "hypohemia," which seems to be a fictional counterpart to hypovolemia (a lack of total bodily fluid) and/or anemia (a lack of red blood cells). Given that in subsequent episodes he's shown to require semi-regular blood transfusions, it's hinted to be closer to the latter.

* ''Literature/CodexAlera'': Tavi, the main character, is the only human who can't use magic in a world where it's used for everything from travel to turning lights on and off. He is treated like a freak.

* ''Literature/SwordArtOnline'' includes a condition called [="FullDive Non-Conformity"=], where someone is unable to play thought-controlled VirtualReality games properly due to unusual brain structure. In most cases this results in dulled sensory feedback or unusually high lag, but in one case (Eiji from the movie ''[[Anime/SwordArtOnlineTheMovieOrdinalScale Ordinal Scale]]'') it had the unusual effect of overestimating his level of fear, causing his avatar to become paralysed in even mildly tense situations. This is used to explain how someone with as much real-life fighting skill as Eiji never made a name for himself in the ''SAO'' death game. The AnimatedAdaptation of the books' ''War of the Underworld'' arc includes a {{Filler}} episode where Eiji returns and somehow manages to overcome his brain structure through HeroicWillpower in a ([[ShaggyDogStory failed]]) stand against TheDragon of the arc.

* In the ''Literature/{{Animorphs}}'' fanfic series ''Fanfic/{{Eleutherophobia}}'', ex-hosts frequently have a disorder called Post-Infestation Affective Blunting Syndrome. Due to not being able to use their own bodies for so long, their brains lose the ability to perform automatic actions. They rarely make facial expressions, have uncoordinated movements and slurred speech, and take a while to respond to outside stimuli.

** In ''WebAnimation/DinkysDestiny'', Dinky Hooves is a unicorn foal who can't use magic well due to her clockwise horn.

*** In [[Recap/TriptychContinuumScootalift Scootalift]], Snowflake diagnoses Scootaloo with being a slow / late developer, so she will take longer than other pegasi to be able to fly.

* In ''WesternAnimation/BarbieFairytopia'' the protagonist, Elina, is the only fairy in her meadow without wings, which she is teased constantly about. [[spoiler: Although by the end of the movie she is given wings by the Enchantress, the ruler of the fairies.]]

* In ''Literature/TheCaseOfTheToxicSpellDump'', exposure to the magic equivalent of toxic waste can cause infants to be born without a soul and apparently simply stop existing after death--no afterlife, no nothing. The condition is called "apsychia", and is considered a birth defect; the protagonist meets a medical researcher who is working on an experimental procedure in which tiny pieces of many souls are fused into, essentially, a synthetic soul which can then be implanted in the apsychic child. Whether this will actually work is still unclear.
* Tavi, the main character in ''Literature/CodexAlera,'' is the only human who ''can't'' use magic in a world where it's used for everything from travel to turning lights on and off. He is treated like a freak.

* Atsuko "Akko" Kagari in ''Anime/LittleWitchAcademia'' is already heavily coded as having ADHD, but it later turns out that this is not the only disability she suffers that prevents her from learning magic at the same rate as her peers. [[spoiler:As a child, her magic was drained by Croix' dream fuel spirit, which stunted her magical potential. While this can be overcome through hard training and practice, as seen with Diana who was stunted in the same way but recovered, Akko has never had the support or means to practice magic until she attended Luna Nova, meaning that she had no way to deal with her disability or even learn that she had one]].

* While WordOfSaintPaul from her voice actress is that she’s portrayed to have Obsessive Love Disorder, WordOfGod from the developer [=YandereDev=] is that whatever form of insanity ''VideoGame/YandereSimulator''’s VillainProtagonist Ayano Aishi [[spoiler:and the rest of her matrilineal bloodline]] could be diagnosed with is a fictional one.

** In ''The Other'', an Andalite named Mertil suffers from a condition that makes him unable to use the morphing technology, and his friend Gafinilan suffers from a painful disease known as Soola's Disease, which can only be gotten rid of by acquiring and morphing another Andalite.

* Atsuko "Akko" Kagari in ''Anime/LittleWitchAcademia'' is already heavily coded as having ADHD, but it later turns out that this is not the only disability she suffers that prevents her from learning magic at the same rate as her peers. [[spoiler:As a child, her magic was drained by Croix' dream fuel spirit, which stunted her magical potential. While this can be overcome through hard training and practice, as seen with Diana who was stunted in the same way but recovered, Akko has never had the support or means to practice magic until she attended Luna Nova, meaning that she had no way of dealing with her disability or even learn that she had one]].

** ''Fanfic/ScootalooAndTheCabinetOfSeers'': Scootaloo worries so much about her possibly being never able to fly, she wants Twilight to consult the greatest {{Seers}} of their world about it.

* [[LittleBitBeastly Animal folk]] in the ''VideoGame/LonelyWolfTreat'' series are able shift between humanoid form and their true animal form, and those who remain permanently in their animal form are called naturalists. The in-universe book where this concept is explained clarifies that not all naturalists are so by choice, and that certain magic spells can [[ShapeshifterModeLock permanently prevent animals from shifting into humanoid form]]. It is unknown whether Senbei's mother, the only naturalist to appear in the series, is a voluntary or involuntary naturalist.

* ''Anime/{{Pokemon}}:'' Learning to speak like a human somehow made Meowth unable to learn any new attacks and completely killed off any real potential he had as a battling Pokémon. He can't even use his species' SignatureMove Pay Day, which would have been useful for the ever broke Team Rocket because the move creates money out of nothing.

* ''Anime/HaibaneRenmei'': Reki was born with [[spoiler:grey wings]] instead of [[spoiler:the normal white]] due to [[spoiler:being stuck in a Circle of Sin]]. This left her [[AllOfTheOtherReindeer ostracized by others]]. She [[HideYourOtherness hides this]] deformity by [[spoiler:dyeing her wings]].

* akko in ''Anime/LittleWitchAcademia'' is already heavily coded as having ADHD, but it later turns out that this is not the only disability she suffers that prevents her from learning magic at the same rate as her peers. [[spoiler:As a child, her magic was drained by Croix' dream fuel spirit, which stunted her magical potential. While this can be overcome through hard training and practice, as seen with Diana who was stunted in the same way but recovered, Akko has never had the support or means to practice magic until she attended Luna Nova, meaning that she had no way of dealing with her disability or even learn that she had one]].