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* While WordOfSaintPaul from her voice actress is that she’s portrayed to have Obsessive Love Disorder, WordOfGod from the developer [=YandereDev=] is that whatever form of insanity ''VideoGame/YandereSimulator''’s VillainProtagonist Ayano Aishi [[spoiler:and the rest of her matrilineal bloodline]] could be diagnosed with is a fictional one.
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* ''Literature/SwordArtOnline'' includes a condition called [="FullDive Non-Conformity"=], where someone is unable to play thought-controlled VirtualReality games properly due to unusual brain structure. In most cases this results in dulled sensory feedback or unusually high lag, but in one case (Eiji from the movie ''[[Anime/SwordArtOnlineTheMovieOrdinalScale Ordinal Scale]]'') it had the unusual effect of overestimating his level of fear, causing his avatar to become paralysed in even mildly tense situations. This is used to explain how someone with as much real-life fighting skill as Eiji never made a name for himself in the ''SAO'' death game. The AnimatedAdaptation of the books' ''War of the Underworld'' arc includes a {{Filler}} episode where Eiji returns and somehow manages to overcome his brain structure through HeroicWillpower in a ([[ShaggyDogStory failed]]) stand against TheDragon of the arc.
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* ''Manga/DeliciousInDungeon'': [[spoiler:The Captain of the Canaries, Mithrun]], is extremely absent-minded due to having all his bodily desires eaten by a demon after being trapped in a LotusEaterMachine, leaving only a burning desire to destroy all demons. As a result, he often forgets to eat, sleep, or go to the bathroom unless repeatedly prompted, or will otherwise just keep going until he collapses from exhaustion. In fact, he ''can't'' sleep normally and has to be coaxed via relaxation techniques such as a spell, medication, or a massage. On top of that, he also has no depth perception, due to having [[EyeScream an eye gouged out]] by the same demon, and a ridiculously bad sense of direction.
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* [[LittleBitBeastly Animal folk]] in the ''VideoGame/LonelyWolfTreat'' series are able shift between humanoid form and their true animal form, and those who remain permanently in their animal form are called naturalists. The in-universe book where this concept is explained clarifies that not all naturalists are so by choice, and that certain magic spells can [[ShapeshifterModeLock permanently prevent animals from shifting into humanoid form]]. It is unknown whether Senbei's mother, the only naturalist to appear in the series, is a voluntary or involuntary naturalist.
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* Seteth and Flayn from ''VideoGame/FireEmblemThreeHouses'' qualify for the "fantastic condition" category. [[spoiler:They're part of the Nabatean race, people who can normlly transform into draconic forms. Neither of them have their dragon forms shown on-screen though, unlike Rhea (who is shown transforming in both the ''Crimson Flower'' and ''Silver Snow'' routes) or Indech and Macuil (who are only ever seen in their dragon forms). Seteth specifically mentions having "lost" his ability to transform, while Flayn suffered heavy injuries that caused her to sleep for several hundred years to heal. Presumably, they both suffered some kind of physical damage that keeps them from transforming.]] While they have few difficulties with things most normal people do, [[spoiler:they're both permanently locked out of an ability that most of their species has]].

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* Seteth and Flayn from ''VideoGame/FireEmblemThreeHouses'' qualify for the "fantastic condition" category. [[spoiler:They're part of the Nabatean race, people who can normlly normally transform into draconic forms. Neither of them have their dragon forms shown on-screen though, unlike Rhea (who is shown transforming in both the ''Crimson Flower'' and ''Silver Snow'' routes) or Indech and Macuil (who are only ever seen in their dragon forms). Seteth specifically mentions having "lost" his ability to transform, while Flayn suffered heavy injuries that caused her to sleep for several hundred years to heal. Presumably, they both suffered some kind of physical damage that keeps them from transforming.]] While they have few difficulties with things most normal people do, [[spoiler:they're both permanently locked out of an ability that most of their species has]].

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* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler:until he travelled to the Rewind Spring, where Pandora revived herself from said powers]].

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* Seteth and Flayn from ''VideoGame/FireEmblemThreeHouses'' qualify for the "fantastic condition" category. [[spoiler:They're part of the Nabatean race, people who can normlly transform into draconic forms. Neither of them have their dragon forms shown on-screen though, unlike Rhea (who is shown transforming in both the ''Crimson Flower'' and ''Silver Snow'' routes) or Indech and Macuil (who are only ever seen in their dragon forms). Seteth specifically mentions having "lost" his ability to transform, while Flayn suffered heavy injuries that caused her to sleep for several hundred years to heal. Presumably, they both suffered some kind of physical damage that keeps them from transforming.]] While they have few difficulties with things most normal people do, [[spoiler:they're both permanently locked out of an ability that most of their species has]].
* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler:until he travelled traveled to the Rewind Spring, where Pandora revived herself from said powers]].
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** Eda's curse where she turns into a massive owl beast is treated as if it were a disability in-universe. She takes potions to suppress the transformation, things like stress and sleep deprivation can make it worse, and it affects her body in other ways as well, such as corrupting her magic and allowing her to detach her limbs at will. [[spoiler:Eda eventually comes to accept that her curse is never going to go away, and that learning to live with it is her best course of action]].

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** Eda's curse where she turns into a massive owl beast is treated as if it were a disability chronic illness in-universe. She takes potions to suppress the transformation, things like stress and sleep deprivation can make it worse, and it affects her body in other ways as well, such as corrupting her magic and allowing her to detach her limbs at will. [[spoiler:Eda eventually comes to accept that her curse is never going to go away, and that learning to live with it is her best course of action]].
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* ''Manga/WorldsEndHarem'': Cellular sclerosis (the literal translation of the kana is "cytosclerosis", which means the same thing), a degenerative disorder with no stated cause that afflicts all five surviving males in the world. Either the disease, the cure that was developed while they were {{Human Popsicle}}s, or a combination of the two, gave them DisabilityImmunity to the [[{{Gendercide}} Male-Killer Virus]].
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* ''Series/StarTrekDeepSpaceNine'': In "[[Recap/StarTrekDeepSpaceNineS02E06Melora Melora]]", the eponymous character is [[{{Lightworlder}}from a planet with very low gravity]]. Most Elaysians never leave their homeworld for this reason. Melora adapting to "standard" gravity requires a special chair, which is treated as if it were a disability. She starts treatment that would make it possible for her to function completely normally in standard gravity but decides not to go through with it as it means she'd never be able to return to her homeworld.

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* ''Series/StarTrekDeepSpaceNine'': In "[[Recap/StarTrekDeepSpaceNineS02E06Melora Melora]]", the eponymous character is [[{{Lightworlder}}from [[{{Lightworlder}} from a planet with very low gravity]]. Most Elaysians never leave their homeworld for this reason. Melora adapting to "standard" gravity requires a special chair, which is treated as if it were a disability. She starts treatment that would make it possible for her to function completely normally in standard gravity but decides not to go through with it as it means she'd never be able to return to her homeworld.
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* ''Series/StarTrekDeepSpaceNine'': In "[[Recap/StarTrekDeepSpaceNineS02E06Melora Melora]]", the eponymous character is from a planet with very low gravity. Most Elaysians never leave their homeworld for this reason. Melora adapting to "standard" gravity requires a special chair, which is treated as if it were a disability. She starts treatment that would make it possible for her to function completely normally in standard gravity but decides not to go through with it as it means she'd never be able to return to her homeworld.

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* ''Series/StarTrekDeepSpaceNine'': In "[[Recap/StarTrekDeepSpaceNineS02E06Melora Melora]]", the eponymous character is from [[{{Lightworlder}}from a planet with very low gravity.gravity]]. Most Elaysians never leave their homeworld for this reason. Melora adapting to "standard" gravity requires a special chair, which is treated as if it were a disability. She starts treatment that would make it possible for her to function completely normally in standard gravity but decides not to go through with it as it means she'd never be able to return to her homeworld.
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* Starfire in the ''WesternAnimation/TeenTitans'' season one finale is shown to have an allergy to metallic chromium, which for the plot is convenient since the TimeStandsStill bomb device Slade uses a good deal of it so they can track down its location by Starfire sneezing. As long as the other Titans don't stand too close to her when she sneezes and makes little explosions.

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* Starfire in the ''WesternAnimation/TeenTitans'' season one finale is shown to have an allergy to metallic chromium, which for the plot is convenient since the TimeStandsStill bomb device Slade is constructing uses a good deal of it so they can track down its location by Starfire sneezing. As long as the other Titans don't stand too close to her when she sneezes and makes little explosions.
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* Starfire in the ''WesternAnimation/TeenTitans'' season one finale is shown to have an allergy to metallic chromium, which for the plot is convenient since the TimeStandsStill bomb device Slade uses a good deal of it so they can track down its location by Starfire sneezing. As long as the other Titans don't stand too close to her when she sneezes and makes little explosions.
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* ''WesternAnimation/ToyStory2'': Wheezy's missing squeaker is treated as if it's this trope.

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* ''WesternAnimation/ToyStory2'': Wheezy's Wheezy has a missing squeaker, and it’s portrayed as though it’s a toy form of asthma, with him constantly... well, wheezing. At the end of the film, he [[spoiler:gets a squeaker is treated as if it's this trope.put in him and sounds fine, with him even being able to [[NonSingingVoice sing like a lounge singer]]]].
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* ''[[Literature/TheShadowFairyTale The Shadow]]'': Parodied with the Princess. She is at a health resort because of her disease of "being too sharp-sighted, which made every one very uneasy".
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* ''Series/BlackBooks'': Played for laughs in an episode where Manny reveals to Bernard that he suffers from a condition called "Dave's Syndrome", which will cause bad things to happen if the temperature hits 88 degrees Fahrenheit. Bernard treats this as a joke and decides to deliberately make Manny overheat in order to see what will happen, but forgets about the whole thing by the end of the episode. The last shot is a trail of destruction and beaten-up bystanders leading to Manny jumping up and down on the bonnet of a car, waving a torch, naked except for a hot water bottle strapped to his groin and EAT ME painted on his torso, as a pair of pedestrians look at him sadly and one says to the other, "Poor bloke -- Dave's Syndrome".

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* ''Series/BlackBooks'': Played for laughs in an episode where Manny reveals to Bernard that he suffers from a condition called "Dave's Syndrome", which will cause bad things to happen if the temperature hits 88 degrees Fahrenheit. Bernard treats this as a joke and decides to deliberately make Manny overheat in order to see what will happen, but forgets about the whole thing by the end of the episode. The last shot is a trail of destruction and beaten-up bystanders leading to Manny jumping up and down on the bonnet roof of a car, waving a torch, naked except for a hot water bottle strapped to his groin and EAT ME painted on his torso, as a pair of pedestrians look at him sadly and one says to the other, "Poor bloke -- Dave's Syndrome".
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Examples are not general.


** Many fan works expand on Scootaloo's canonical inability to fly. Some of them have her being told that she will never fly, and having to cope with that. Others suggest that there is hope for her to get flying, but she has some condition which would give her a harder time getting there than the average pegasus. A few of them have her flying with the aid of [[ArtificialLimbs prosthetic wings]], gliders, or other technology (just as many people with disabilities in real life use technology to compensate).

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* Similarly, Unsouled from the ''Literature/CradleSeries'' are born with a weak soul that prevents them from doing the magic that even some plants and animals can do. They are banned from marriage lest they pass on their affliction, and are considered beneath contempt.

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* Similarly, Unsouled from the ''Literature/CradleSeries'' ''Literature/CradleSeries'': In Sacred Valley, people labeled "unsouled" are born with a weak soul that prevents them from doing the magic that even some plants and animals can do. They are banned from marriage lest they pass on their affliction, and are considered beneath contempt. As it turns out, no one in Sacred Valley has any idea what they're talking about; according to Suriel, it's nothing but a minor [[{{Mana}} madra]] deficiency that can easily be made up with a little bit of specialized training or reasonably expensive medicine. Yerin had never even heard of the "disability" until she came to Sacred Valley.
-->'''Yerin:''' You just started two steps behind, that's the spine of it. Nothing worth crying about. Some of them polished families can take a squalling baby from [[PowerLevels Foundation to Jade]] in two and a half pills.

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* ''WesternAnimation/TheOwlHouse'': The Golden Guard, aka Hunter, is incapable of doing magic without his staff, despite being a [[MageSpecies witch]]. [[spoiler:It's later revealed that he's actually a magically-created clone called a Grimwalker, although it's unknown if his lack of magic is because he was cloned from a human or if all Grimwalkers lack it regardless of what they were made from]].
* ''WesternAnimation/StevenUniverse'': Gems are artificially created for specific purposes in their HiveCasteSystem. At times, however, the circumstances of their "birth" leave them with various defects of deformities, giving them different body-types and even differences in their powers, abilities, and mindsets. These types of gems are referred to as "Off-Color". Due to the gems' strict caste system, these are usually discarded, persecuted, and even exterminated:

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* ''WesternAnimation/TheOwlHouse'': The Golden Guard, aka Hunter, ''WesternAnimation/TheOwlHouse'':
** Eda's curse where she turns into a massive owl beast
is incapable of doing treated as if it were a disability in-universe. She takes potions to suppress the transformation, things like stress and sleep deprivation can make it worse, and it affects her body in other ways as well, such as corrupting her magic without his staff, despite being a and allowing her to detach her limbs at will. [[spoiler:Eda eventually comes to accept that her curse is never going to go away, and that learning to live with it is her best course of action]].
** Unlike most other
[[MageSpecies witch]].witches]], Hunter has no innate magic, and can only cast spells using his artificial magic staff or his Palisman. [[spoiler:It's later revealed that he's actually a magically-created clone called a Grimwalker, although it's unknown if his lack of magic is because he was cloned from a human or if all Grimwalkers lack it regardless of what they were made from]].
* ''WesternAnimation/StevenUniverse'': Gems are artificially created for specific purposes in their HiveCasteSystem. At times, however, the circumstances of their "birth" leave them with various defects of deformities, giving them different body-types and even differences in their powers, abilities, and mindsets. These types of gems are referred to as "Off-Color". Due to the gems' strict caste system, these are usually discarded, persecuted, and even exterminated:exterminated.



** Because Earth's beta Kindergarten was made under lax conditions in a hurry due to an ongoing war, most of the quartzes made there likewise deviate from their intended build. Carnelian has a figure similar to Amethyst, while Skinny Jasper is very thin.

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** Because Earth's beta Kindergarten was made under lax conditions in a hurry due to an ongoing war, most of the quartzes made there likewise deviate from their intended build. Carnelian has a figure similar to Amethyst, while Skinny Jasper is very thin.has the lanky build of a Pearl.

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* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler: until he travelled to the Rewind Spring, where Pandora revived herself from said powers]].

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* ''VideoGame/FinalFantasyXIV'':
** Most people in the setting are able to manipulate the aether in their own bodies to perform feats of magic, provided they have sufficient training. However, there are some who born with such low reserves of aether that it's impossible for them to cast even the simplest spells. There are others who have, either from birth or from a magical accident, lost the ability to manipulate aether altogether, rendering them incapable of utilizing any technology requiring the application of aether, such as aetherytes.
** Much like how people can get motion sick in real life, some people suffer from acute aether sickness, meaning that trying to transport themselves with an aetheryte will lead to nausea, vomiting, and dizzyness. Professor T'laqua Tia in Sharlayan suffers from this, requiring the aid of an adept angler to help him complete his thesis on time because he can't attune to an aetheryte without collapsing. This can also be briefly induced unto others through the use of experimental aetherytes. After taking one such aetheryte to Thavnair, the Warrior, Thancred, and Urianger all fight to keep their lunch down.
* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler: until [[spoiler:until he travelled to the Rewind Spring, where Pandora revived herself from said powers]].

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** ''WesternAnimation/MyLittlePonyTheMovie2017'': Tempest Shadow has a broken horn as a result of an accident as a filly. While it doesn't negate her ability to use magic entirely, she is unable to use even basic skills such as telekinesis and can only release her magic as an uncontrolled, destructive torrent of energy.[[note]]Her subsequent appearances in the IDW comic have her using telekinesis, but with a very different aura than a unicorn with an intact horn.[[/note]]

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** * ''WesternAnimation/MyLittlePonyTheMovie2017'': Tempest Shadow has a broken horn as a result of an accident as a filly. While it doesn't negate her ability to use magic entirely, she is unable to use even basic skills such as telekinesis and can only release her magic as an uncontrolled, destructive torrent of energy.[[note]]Her subsequent appearances in the IDW comic have her using telekinesis, but with a very different aura than a unicorn with an intact horn.[[/note]]


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* ''Literature/TatuAndPatu'': Tatu has a condition only known in Oddsville that causes his eyeballs to sweat, and has to wear glasses with ventilation to prevent it.
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* Tavi, the main character in ''Literature/CodexAlera,'' is the only human who ''can't'' use magic in a world where it's used for everything from travel to turning lights on and off. He is treated like a freak.
* Similarly, Unsouled from the ''Literature/CradleSeries'' are born with a weak soul that prevents them from doing the magic that even some plants and animals can do. They are banned from marriage lest they pass on their affliction, and are considered beneath contempt.

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Moved entry to "Film"


** ''WesternAnimation/MyLittlePonyTheMovie2017'': Tempest Shadow has a broken horn as a result of an accident as a filly. While it doesn't negate her ability to use magic entirely, she is unable to use even basic skills such as telekinesis and can only release her magic as an uncontrolled, destructive torrent of energy.[[note]]Her subsequent appearances in the IDW comic have her using telekinesis, but with a very different aura than a unicorn with an intact horn.[[/note]]



** ''WesternAnimation/MyLittlePonyTheMovie2017'': Tempest Shadow has a broken horn as a result of an accident as a filly. While it doesn't negate her ability to use magic entirely, she is unable to use even basic skills such as telekinesis and can only release her magic as an uncontrolled, destructive torrent of energy.[[note]]Her subsequent appearances in the IDW comic have her using telekinesis, but with a very different aura than a unicorn with an intact horn.[[/note]]
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* ''WesternAnimation/TheOwlHouse'': [[spoiler:The Golden Guard, aka Hunter]] is incapable of doing magic without [[spoiler:his]] staff, despite being a [[MageSpecies witch.]]

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* ''WesternAnimation/TheOwlHouse'': [[spoiler:The The Golden Guard, aka Hunter]] Hunter, is incapable of doing magic without [[spoiler:his]] his staff, despite being a [[MageSpecies witch.]]witch]]. [[spoiler:It's later revealed that he's actually a magically-created clone called a Grimwalker, although it's unknown if his lack of magic is because he was cloned from a human or if all Grimwalkers lack it regardless of what they were made from]].
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* The ''Literature/VorkosiganSaga'': Vorzohn's Dystrophy, a fictional hereditary degenerative disorder on the planet Barrayar (which presumably developed on that planet in the centuries since it was settled) plays a significant role in ''Komarr''. Barrayar is a world where "mutants" of any kind are hated and feared. The character Tien Vorsoisson's failures in dealing with his own condition (and that of his son, Nikki) wind up driving events that change the life of the series protagonist, Miles Vorkosigan, in a very important way, since [[spoiler:Miles later winds up marrying Tien's widow Ekatarin and becoming stepfather to Nikki Vorsoisson, after Tien dies (albeit not directly of Vorzohn's Dystrophy, but Tien's desperation to treat his condition in total secrecy drives his actions which lead to his death)]].
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* ''TabletopGame/BattleTech'': Transit Disorientation Syndrome AKA jump sickness is a condition experienced by some people as a result of undergoing a hyperspace jump. The symptoms manifest as headaches, nausea, diarrhea, and/or irritability and typically last for a few hours before fading. Undergoing a second jump while still suffering from it can lead to much stronger symptoms that can last for days or more rarely weeks. There's no cure for the condition, only treatments for the symptoms.
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* ''WesternAnimation/TheOwlHouse'': [[spoiler:The Golden Guard, aka Hunter]] is incapable of doing magic without [[spoiler:his]] staff, despite being a [[MageSpecies witch.]]
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"fixing" as it relates to disabilities is a little questionable


# Disabilities in non-humans with BizarreAlienBiology. (e.g. a member of a flying species who is effectively flightless).

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# Disabilities in non-humans with non-humans, especially as it pertains to BizarreAlienBiology. (e.g. a member of a flying species with a wing injury, or a member of a telepathic species who is effectively flightless).can't read minds).



This trope can be used as a way to write disabled characters in settings that have magic or technology which would fix most real-life disabilities, or to explore the social consequences of the magic and technology existing (although this can lead to a SpaceWhaleAesop; "Don't invent faster computers or people will lose the ability to eat plant matter!"). {{Cyberpunk}} and other social science fiction settings love using both variations, since including characters who can't benefit from the technology is a fascinating way of analysing its effect on society.

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This trope can be used as a way to write disabled characters in settings that have magic or technology which would fix where most real-life disabilities, disabilities would be rendered uncommon as a result of magic or advanced technology, or to explore the social consequences of the said magic and technology existing (although this can lead to a SpaceWhaleAesop; "Don't invent faster computers or people will lose the ability to eat plant matter!"). {{Cyberpunk}} and other social science fiction settings love using both variations, since including characters who can't benefit from the technology is a fascinating way of analysing its effect on society.
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* ''ComicBook/Transformers2019'' treats being an Action Master (a transformer unable to transform into vehicle mode) as a disability, particularly in ''Wreckers: Treads and Circuits'' which is set on vehicle centric Velocitron.
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** The most frequently referenced is him having a "Narrow Urethra", which renders him ''nearly'' infertile. In reality, no such condition exists, and the width of the male urethra has no connection to fertility.
** Another episode reveals he suffers from a condition called "Diminished Gluteal Syndrome (DGS)", which basically means he "has no ass", forcing him to sit on a prosthetic buttocks. The condition is fictional, but the symptoms are in line with real conditions, such as Deep Gluteal Syndrom, Piriforis Syndrome, and Dead Butt Syndrome. The prosthesis is entirely fictional though.

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** The most frequently referenced is him having a "Narrow Urethra", "narrow urethra", which renders him ''nearly'' infertile.infertile and was apparently a reason for the Army to reject him, fearing he wouldn't be able to adequately relieve himself in times of stress. In reality, no such condition exists, and the width of the male urethra has no connection to fertility.
** Another episode reveals he suffers from a condition called "Diminished Gluteal Syndrome (DGS)", which basically means he "has no ass", forcing him to sit on a prosthetic buttocks. The condition is fictional, but the symptoms are in line with real conditions, such as Deep Gluteal Syndrom, Syndrome, Piriforis Syndrome, and Dead Butt Syndrome. The prosthesis is entirely fictional though.
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* ''Series/BabylonFive'': In "[[Recap/BabylonFiveS01E21TheQualityOfMercy The Quality of Mercy]]", Laura Rosen is revealed to be dying from Lake's Syndrome. The only distinguishing characteristic is that it induces almost unbearable pain, described by Rosen as akin to having arthritis, blurry vision, the intestines seeming like they are on fire, and veins burning with pain. When Mueller gets a dose of it via the alien device, he is instantly incapacitated by the sheer intensity of it.

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