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* ''VideoGame/MortalKombatArmageddon'': Shao Kahn's arcade ending is the canonical one, [[spoiler:as he ultimately wins after the events of said Armageddon by surviving the ascent up the pyramid and follows that by killing [[PhysicalGod Raiden]] (who sends a message to his past self about the events, thus setting the stage for ''VideoGame/MortalKombat9''). Finding out his [[MeaninglessVillainVictory victory is meaningless]] as there's nothing else left to conquer, Shao Kahn becomes a screaming wreck]].
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* ''WesternAnimation/SpongebobSquarepants'', in "The Clash of Triton", Triton was the son of Neptune. At first, Triton had interests on the mortal fish's lives, and creating cures, but his father, disapproves of this, and pushes him into becoming a mighty god. So he resorts to one thing, exiling Triton to the Island in the Sky, after since he's been there so many years, Triton has developed an extreme hatred to his father, and plotted vengeance upon him. Once {{SpongeBob}} and Patrick released him form his cage, Triton makes his vengeance by destroying Bikini Bottom, but after all this damage, Neptune has actually become proud of how Triton's become, and so they bond once again.

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* ''WesternAnimation/SpongebobSquarepants'', in "The Clash of Triton", Triton was the son of Neptune. At first, Triton had interests on the mortal fish's lives, and creating cures, but his father, disapproves of this, and pushes him into becoming a mighty god. So he resorts to one thing, exiling Triton to the Island in the Sky, after since he's been there so many years, Triton has developed an extreme hatred to his father, and plotted vengeance upon him. Once {{SpongeBob}} [=SpongeBob=] and Patrick released him form his cage, Triton makes his vengeance by destroying Bikini Bottom, but after all this damage, Neptune has actually become proud of how Triton's become, and so they bond once again.
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* ''WesternAnimation/SpongebobSquarepants'', in "The Clash of Triton", Triton was the son of Neptune. At first, Triton had interests on the mortal fish's lives, and creating cures, but his father, disapproves of this, and pushes him into becoming a mighty god. So he resorts to one thing, exiling Triton to the Island in the Sky, after since he's been there so many years, Triton has developed an extreme hatred to his father, and plotted vengeance upon him. Once SpongeBob and Patrick released him form his cage, Triton makes his vengeance by destroying Bikini Bottom, but after all this damage, Neptune has actually become proud of how Triton's become, and so they bond once again.

to:

* ''WesternAnimation/SpongebobSquarepants'', in "The Clash of Triton", Triton was the son of Neptune. At first, Triton had interests on the mortal fish's lives, and creating cures, but his father, disapproves of this, and pushes him into becoming a mighty god. So he resorts to one thing, exiling Triton to the Island in the Sky, after since he's been there so many years, Triton has developed an extreme hatred to his father, and plotted vengeance upon him. Once SpongeBob {{SpongeBob}} and Patrick released him form his cage, Triton makes his vengeance by destroying Bikini Bottom, but after all this damage, Neptune has actually become proud of how Triton's become, and so they bond once again.
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* ''WebAnimation/InaimateInsanity'', the character Paper was a contestant of Season 1. But then after losing a tiebreaker with Knfie, Paper was the first person eliminated, and was sent to Idiotic Island. During his long exile, Paper's mental health was greatly affected, and as soon as he returns to the show, he develops a SplitPersonality, Evil Paper, a person who takes acts of violence.


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* ''WesternAnimation/SpongebobSquarepants'', in "The Clash of Triton", Triton was the son of Neptune. At first, Triton had interests on the mortal fish's lives, and creating cures, but his father, disapproves of this, and pushes him into becoming a mighty god. So he resorts to one thing, exiling Triton to the Island in the Sky, after since he's been there so many years, Triton has developed an extreme hatred to his father, and plotted vengeance upon him. Once SpongeBob and Patrick released him form his cage, Triton makes his vengeance by destroying Bikini Bottom, but after all this damage, Neptune has actually become proud of how Triton's become, and so they bond once again.
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* ''Anime/FullmetalAlchemist2003'': Shou Tucker's whole career is a slow spiral that never lets up. After a lifetime in poverty, he turns his wife into a monstrous chimera to become a State Alchemist. The demands of the job eventually drive him to do the same to [[KickTheMoralityPet his beloved daughter and dog]] only for them to die, and him to perform more twisted experiments to resurrect her. His body is horribly mutated by his own alchemy, and all he succeeds in doing is making a series of lifeless shells resembling Nina. By the end he loses what's left of his mind and retreats into a fantasy where his family is still alive. [[AlasPoorVillain Even Edward, who was furious at Tucker's actions, can only pity the man.]]

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* ''WesternAnimation/{{Animaniacs}}'': Accordingly, the Warner Kids almost invariably manage to do this to anyone they have adopted as their "Special Friend" (generally someone who is being a jerk to start with).

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* ''WesternAnimation/{{Animaniacs}}'': ''WesternAnimation/{{Animaniacs}}'':
**
Accordingly, the Warner Kids almost invariably manage to do this to anyone they have adopted as their "Special Friend" (generally someone who is being a jerk to start with).with).
** According to "The Warners' 65th Anniversary", Lon Borax, the in-universe creator of the Warners, apparently "went all funny in the head" after adding the Warner siblings to one of Buddy's shorts. It's unclear if it was the Warners who did it, or if it was the stress from working all into the night. Either way, he's still nuts to this very day. But according to Memlo, he heard he was recovering.
-->'''Borax:''' WE'RE HAVING ''SOUP'' TODAY!!!
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* ''WesternAnimation/AmericanDad'': Stan Smith is such an idiot he repeatedly forgets his anniversary despite how terrifying his wife Francine gets when he does. In "American Fung", he hastily gets Francine committed to a mental hospital for a few days so he can have more time to plan. Again, Stan is such an idiot he keeps forgetting the reason Francine was locked up, and by the day she's released, he has nothing prepared. When Stan greets Francine with a bucket of fried chicken and offers an incredibly half-assed explanation of how he did everything "for love", Francine not only states she genuinely hates Stan but she goes insane for real and gets committed indefinitely.

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* ''WesternAnimation/AmericanDad'': Stan Smith is such an idiot that he repeatedly forgets his anniversary anniversary, despite how terrifying his wife Francine gets when he does. In "American Fung", he hastily gets Francine committed to a mental hospital for a few days so he can have more time to plan. Again, Stan is such an idiot that he keeps forgetting the reason Francine was locked up, and by the day she's released, he has nothing prepared. When Stan greets Francine with a bucket of fried chicken and offers an incredibly half-assed explanation of how he did everything "for love", Francine not only states she genuinely hates Stan Stan, but she goes insane for real and gets committed indefinitely.

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Updating Links, Alphabatizing


* Happens to [[WhiteCollarCrime Warren White]], a white-collar criminal who [[OnlySaneMan finds himself in Arkham Asylum]] in the limited series ''ComicBook/ArkhamAsylumLivingHell''. As the story progresses, Warren is continually tortured, abused and terrorized by the other inmates, until finally, he is locked inside Mr. Freeze's empty cell by an inmate trying to steal his identity, where he loses his nose, his lips, some of his fingers, and his ears to frostbite. Now a "freak" himself, Warren transforms himself into the villain The Great White Shark.
* ''[[ComicBook/TheKillingJoke Batman: The Killing Joke]]'': In which The Joker attempts to drive Commissioner Gordon insane and fails.
** Unfortunately, a detective who has the misfortune of overseeing Joker being processed through to jail in Batman Confident is indeed driven to madness, turning into a cop-killing psychopath who ultimately commits suicide when he realizes how Joker turned him into a monster.
*** Subverted with Harley Quinn, who was was insane but functional when she first met the Joker; Joker simply gave her an excuse to give up control to her crazy side. As someone put it elsewhere on the site, "the Joker might have driven her mad, but Harley was willing to car-pool."
** After having MadScientist Hugo Strange beaten to death, 'Boss' Rupert Thorne is visited by Strange's ghost until he eventually goes mad and is sent to Arkham Asylum.
* In ''ComicBook/TheBoys'', [[spoiler:Black Noir, the clone of Homelander,]] drove Homelander insane by mailing him photos of Homelander [[spoiler:actually Noir dressed up as Homelander]] eating babies, eating hearts, and committing violent murder-rapes. Homelander became an insane monster because he thought he was already a monster and just didn't remember it.
* Used to be part of ComicBook/{{Diabolik}}'s modus operandi. He stopped doing that, but by that time [[TheDogBitesBack he had earned himself two formidable enemies in the form of one of these victims and the son of another.]]

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* ''ComicBook/{{Batman}}'':
**
Happens to [[WhiteCollarCrime Warren White]], a white-collar criminal who [[OnlySaneMan finds himself in Arkham Asylum]] in the limited series ''ComicBook/ArkhamAsylumLivingHell''. As the story progresses, Warren is continually tortured, abused and terrorized by the other inmates, until finally, he is locked inside Mr. Freeze's empty cell by an inmate trying to steal his identity, where he loses his nose, his lips, some of his fingers, and his ears to frostbite. Now a "freak" himself, Warren transforms himself into the villain The Great White Shark.
* ** ''[[ComicBook/TheKillingJoke Batman: The Killing Joke]]'': In which The Joker attempts to drive Commissioner Gordon insane and fails.
** *** Unfortunately, a detective who has the misfortune of overseeing Joker being processed through to jail in Batman Confident is indeed driven to madness, turning into a cop-killing psychopath who ultimately commits suicide when he realizes how Joker turned him into a monster.
*** **** Subverted with Harley Quinn, who was was insane but functional when she first met the Joker; Joker simply gave her an excuse to give up control to her crazy side. As someone put it elsewhere on the site, "the Joker might have driven her mad, but Harley was willing to car-pool."
** *** After having MadScientist Hugo Strange beaten to death, 'Boss' Rupert Thorne is visited by Strange's ghost until he eventually goes mad and is sent to Arkham Asylum.
** Everyone who didn't die horribly from The Cobblepot Expedition ship in ''ComicBook/BatmanTheDoomThatCameToGotham'' wound up devolving into madness. Professor Cobblepot himself is seen walking around naked in the sub-zero temperatures, having become a part of a group of local penguins, while Mister Freeze is transformed into a crazed undead monster, desperately trying to free the MonsterInTheIce that did this to him.
* In ''ComicBook/TheBoys'', ''ComicBook/TheBoys'': [[spoiler:Black Noir, the clone of Homelander,]] drove Homelander insane by mailing him photos of Homelander [[spoiler:actually Noir dressed up as Homelander]] eating babies, eating hearts, and committing violent murder-rapes. Homelander became an insane monster because he thought he was already a monster and just didn't remember it.
* ''ComicBook/{{Diabolik}}'': Used to be part of ComicBook/{{Diabolik}}'s the title character's modus operandi. He stopped doing that, but by that time [[TheDogBitesBack he had earned himself two formidable enemies in the form of one of these victims and the son of another.]]



* The Sheeda in Grant Morrison's ''ComicBook/SevenSoldiers'' take great pride in their ability to break even the noblest of people and re-form them to suit their twisted desires.
** Also from ''ComicBook/SevenSoldiers'', after life has had a good hard go at [[BreakTheCutie breaking]] Sally Sonic, Vitaman essentially forces her to debase herself and then exposes her to [[PsychoSerum Doctor Hyde's Evil Serum]] to finish the job.

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* ''ComicBook/SevenSoldiers'':
**
The Sheeda in Grant Morrison's ''ComicBook/SevenSoldiers'' take great pride in their ability to break even the noblest of people and re-form them to suit their twisted desires.
** Also from ''ComicBook/SevenSoldiers'', after After life has had a good hard go at [[BreakTheCutie breaking]] Sally Sonic, Vitaman essentially forces her to debase herself and then exposes her to [[PsychoSerum Doctor Hyde's Evil Serum]] to finish the job.



* Dr. Eggman in ''ComicBook/SonicTheHedgehogArchieComics'' started suffering a massive one following having his greatest victory -- defeating Sonic, capturing just about everyone and turning Knothole Kingdom into a crater -- swiped from him. He would ultimately snap after one last victory by Sonic pushed him over the edge.
* Incidentally, Franchise/SpiderMan is very good at this even if he doesn't entirely mean to do it.
** Kraven was so confounded by Spider-Man's humiliating defeats that he went nuts and eventually committed suicide.

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* ''ComicBook/SonicTheHedgehogArchieComics'': Dr. Eggman in ''ComicBook/SonicTheHedgehogArchieComics'' started suffering a massive one following having his greatest victory -- defeating Sonic, capturing just about everyone and turning Knothole Kingdom into a crater -- swiped from him. He would ultimately snap after one last victory by Sonic pushed him over the edge.
* ''ComicBook/SpiderMan'': Incidentally, Franchise/SpiderMan Spider-Man is very good at this even if he doesn't entirely mean to do it.
** Kraven ComicBook/KravenTheHunter was so confounded by Spider-Man's humiliating defeats that he went nuts and eventually committed suicide.



* ''Franchise/{{Superman}}'':

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* ''Franchise/{{Superman}}'':''ComicBook/{{Superman}}'':



* In ''ComicBook/VForVendetta'', V kills every Norsefire employee who'd once worked at the concentration camp where he'd been imprisoned. Every employee, that is, except for Lewis Prothero, who as the camp commander had selected him, among other prisoners, to be subjects of medical experimentation. Because said experimentation drove V mad, [[PayEvilUntoEvil he drives Prothero mad]] by kidnapping him, sticking him in a replica of the camp, and cremating his beloved rare doll collection before his eyes.
* ''Franchise/WonderWoman'' [[ComicBook/WonderWoman1942 Vol 1]]: Deborah "Debbie" Domaine was forced into the role of the second ComicBook/{{Cheetah}} by Kobra, and eventually went mad due to their control and manipulations of her life.
* Everyone who didn't die horribly from The Cobblepot Expedition ship in ''ComicBook/BatmanTheDoomThatCameToGotham'' wound up devolving into madness. Professor Cobblepot himself is seen walking around naked in the sub-zero temperatures, having become a part of a group of local penguins, while Mister Freeze is transformed into a crazed undead monster, desperately trying to free the MonsterInTheIce that did this to him.

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* In ''ComicBook/VForVendetta'', ''ComicBook/VForVendetta'': V kills every Norsefire employee who'd once worked at the concentration camp where he'd been imprisoned. Every employee, that is, except for Lewis Prothero, who as the camp commander had selected him, among other prisoners, to be subjects of medical experimentation. Because said experimentation drove V mad, [[PayEvilUntoEvil he drives Prothero mad]] by kidnapping him, sticking him in a replica of the camp, and cremating his beloved rare doll collection before his eyes.
* ''Franchise/WonderWoman'' ''ComicBook/WonderWoman'' [[ComicBook/WonderWoman1942 Vol 1]]: Deborah "Debbie" Domaine was forced into the role of the second ComicBook/{{Cheetah}} by Kobra, and eventually went mad due to their control and manipulations of her life.
* Everyone who didn't die horribly from The Cobblepot Expedition ship in ''ComicBook/BatmanTheDoomThatCameToGotham'' wound up devolving into madness. Professor Cobblepot himself is seen walking around naked in the sub-zero temperatures, having become a part of a group of local penguins, while Mister Freeze is transformed into a crazed undead monster, desperately trying to free the MonsterInTheIce that did this to him.
life.
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* ''Manga/{{Berserk}}'': [[spoiler:The horrific, torturous rape at the hands of Griffith during the Eclipse and watching nearly everyone she cared about getting gruesomely murdered by the Apostles]] has rendered Casca [[CuteMute mute]], [[TraumaInducedAmnesia amnesiac]] and [[TheOphelia insane]], effectively making her into an EmptyShell of her former self.
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The subtrope, {{Gaslighting}}, is the subtle, insidious form of this.

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The subtrope, {{Gaslighting}}, is the subtle, insidious form of this.
this. For unintended descents into madness, see SanitySlippage.
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[[caption-width-right:350:NeverWorkWithChildrenOrAnimals. [[BreadEggsBreadedEggs Or animals that are children.]]]]

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[[caption-width-right:350:NeverWorkWithChildrenOrAnimals. [-[[caption-width-right:350:NeverWorkWithChildrenOrAnimals... [[BreadEggsBreadedEggs Or or animals that are children.]]]]
children]].]]-]
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* In a somewhat unknown Swedish novel, ''Simon's Family'' by Marianne Freddriksson, the character Isak is training at a boot camp. His squadron leader tries to break the spirit of him by being his antisemitic self (Jewish Isak had been molested as a child by Nazis- no I'm not making this up). Isak begins to go numb almost to the point of no return.

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* In a somewhat unknown Swedish novel, ''Simon's Family'' ''Literature/SimonsFamily'' by Marianne Freddriksson, the Jewish character Isak is training at a boot camp. His squadron leader tries to break the spirit of him by being his antisemitic self (Jewish Isak had been molested as a child by Nazis- no I'm not making this up).self. Isak begins to go numb almost to the point of no return.
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* WebVideo/DavidNear: [[https://youtu.be/zpV5siBBGOA Candle Jack]] will take away anyone who says his name, and trap them before driving his captive insane, up to the extent that they'll [[EyeScream gouge their own eyes out]] once they break completely.
--> '''Candle Jack:''' I will tie you up and rapture you away to a final resting place. There you will be driven mad with constant mental simulation! And once I break you and your mind snaps completely, you will gouge your own eyes out of the sockets!
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* Stan Smith of ''WesternAnimation/AmericanDad'' is such an idiot he repeatedly forgets his anniversary despite how terrifying his wife Francine gets when he does. In "American Fung" he hastily gets Francine committed to a mental hospital for a few days so he can have more time to plan. Again, Stan's such an idiot he keeps forgetting the reason Francine was locked up and by the day she's released he has nothing prepared. When Stan greets Francine with a bucket of fried chicken and offers an incredibly half-assed explanation of how he did everything "for love," Francine not only states she genuinely hates Stan she goes insane for real and gets committed indefinitely.
* Accordingly, the Warner Kids of ''WesternAnimation/{{Animaniacs}}'' almost invariably manage to do this to anyone they have adopted as their "Special Friend" (generally someone who is being a jerk to start with).

to:

* ''WesternAnimation/AmericanDad'': Stan Smith of ''WesternAnimation/AmericanDad'' is such an idiot he repeatedly forgets his anniversary despite how terrifying his wife Francine gets when he does. In "American Fung" Fung", he hastily gets Francine committed to a mental hospital for a few days so he can have more time to plan. Again, Stan's Stan is such an idiot he keeps forgetting the reason Francine was locked up up, and by the day she's released released, he has nothing prepared. When Stan greets Francine with a bucket of fried chicken and offers an incredibly half-assed explanation of how he did everything "for love," love", Francine not only states she genuinely hates Stan but she goes insane for real and gets committed indefinitely.
* ''WesternAnimation/{{Animaniacs}}'': Accordingly, the Warner Kids of ''WesternAnimation/{{Animaniacs}}'' almost invariably manage to do this to anyone they have adopted as their "Special Friend" (generally someone who is being a jerk to start with).
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** ''StarTrekTheOriginalSeries'':
*** In "[[Recap/StarTrekS2E6TheDoomsdayMachine The Doomsday Machine]]" SoleSurvior Commodore Matthew Decker is driven mad by the experience of losing his crew and command, and harbors a death wish for having sent the men and women under his command to their deaths. Stopped from wrecking the ''Enterprise'' in an attempt to destroy the Planet Killer, Decker [[DrivenToSuicide decides]] that his death is the only way he can atone for killing his crew, and rams a shuttlecraft down the Planet Killer's maw.
*** Then in "[[Recap/StarTrekS2E23TheOmegaGlory The Omega Glory]]" Captain Tracey goes insane after losing his entire crew to the Omega IV virus, making him the SoleSurvivor. Matters are not helped by Tracey thinking he's found a fountain of youth on the planet and using his phasers to aide the Kohm in their war against the Yangs.

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** ''StarTrekTheOriginalSeries'':
''Series/StarTrekTheOriginalSeries'':
*** In "[[Recap/StarTrekS2E6TheDoomsdayMachine The Doomsday Machine]]" SoleSurvior SoleSurvivor Commodore Matthew Decker is driven mad by the experience of losing his crew and command, and harbors a death wish for having sent the men and women under his command to their deaths. Stopped from wrecking the ''Enterprise'' in an attempt to destroy the Planet Killer, Decker [[DrivenToSuicide decides]] that his death is the only way he can atone for killing his crew, and rams a shuttlecraft down the Planet Killer's maw.
*** Then in "[[Recap/StarTrekS2E23TheOmegaGlory The Omega Glory]]" Captain Tracey goes insane after losing his entire crew to the Omega IV virus, making him the another SoleSurvivor. Matters are not helped by Tracey thinking he's found a fountain of youth on the planet and using his phasers technology to aide the Kohm in their war against the Yangs.

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* ''Series/StarTrekDeepSpaceNine'' has this happen to Gul Dukat after he witnesses [[OutlivingOnesOffspring the death of his daughter]], at the climax of a long string of personal and career setbacks. His redeeming features and likable character traits had been submerged by his arrogance and ruthless ambition many episodes previously, but [[AlasPoorVillain it's hard not to pity him]] as he cradles her corpse and mumbles to her in a broken monotone. Dukat eventually comes out of his VillainousBSOD, but becomes steadily more unhinged and [[TheUnfettered even more dangerous for it]], even before he becomes the Bajoran religious equivalent of a DarkMessiah.

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* ''Franchise/StarTrek'':
** ''StarTrekTheOriginalSeries'':
*** In "[[Recap/StarTrekS2E6TheDoomsdayMachine The Doomsday Machine]]" SoleSurvior Commodore Matthew Decker is driven mad by the experience of losing his crew and command, and harbors a death wish for having sent the men and women under his command to their deaths. Stopped from wrecking the ''Enterprise'' in an attempt to destroy the Planet Killer, Decker [[DrivenToSuicide decides]] that his death is the only way he can atone for killing his crew, and rams a shuttlecraft down the Planet Killer's maw.
*** Then in "[[Recap/StarTrekS2E23TheOmegaGlory The Omega Glory]]" Captain Tracey goes insane after losing his entire crew to the Omega IV virus, making him the SoleSurvivor. Matters are not helped by Tracey thinking he's found a fountain of youth on the planet and using his phasers to aide the Kohm in their war against the Yangs.
**
''Series/StarTrekDeepSpaceNine'' has this happen to Gul Dukat after he witnesses [[OutlivingOnesOffspring the death of his daughter]], at the climax of a long string of personal and career setbacks. His redeeming features and likable character traits had been submerged by his arrogance and ruthless ambition many episodes previously, but [[AlasPoorVillain it's hard not to pity him]] as he cradles her corpse and mumbles to her in a broken monotone. Dukat eventually comes out of his VillainousBSOD, but becomes steadily more unhinged and [[TheUnfettered even more dangerous for it]], even before he becomes the Bajoran religious equivalent of a DarkMessiah.
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* ''Manga/ChainsawMan'': After Denji defeats The Doll Woman physically, Cosmo destroys her mentally by giving her [[MySkullRunnethOver all the knowledge of the cosmos]], reducing Doll Woman and her Dolls into [[EmptyShell wayward husks]] [[MadnessMantra that can only say "Halloween"]].

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* ''Manga/ChainsawMan'': After Denji defeats The Doll Woman physically, Cosmo destroys her mentally by giving her [[MySkullRunnethOver all the knowledge of the cosmos]], reducing Doll Woman and her Dolls into [[EmptyShell wayward husks]] husks [[MadnessMantra that can only say "Halloween"]].
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* ''Manga/ChainsawMan'': After Denji defeats The Doll Woman physically, Cosmo destroys her mentally by giving her [[MySkullRunnethOver all the knowledge of the cosmos]], reducing Doll Woman and her Dolls into wayward husks that can only say "Halloween".

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* ''Manga/ChainsawMan'': After Denji defeats The Doll Woman physically, Cosmo destroys her mentally by giving her [[MySkullRunnethOver all the knowledge of the cosmos]], reducing Doll Woman and her Dolls into [[EmptyShell wayward husks husks]] [[MadnessMantra that can only say "Halloween"."Halloween"]].

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[[folder:Anime and Manga]]
* What Akito Sohma did to Kana in ''Manga/FruitsBasket''. After Akito blinded Hatori for asking for permission to marry Kana, Akito turned against the poor nurse and blamed her so much for Hatori's partial blindness that she went mad. It was so bad that Hatori had to [[spoiler: delete Kana's memories of their relationship.]]
** [[spoiler: Ironically, ''Akito'' herself was driven to madness upon years of monstrous psychological abuse coming from her mother Ren. As a little kid, Akito was naive and bad-tempered but not evil; however, she completely SNAPPED and became a massive {{Yandere}} with some of the worst issues in the whole cast.]]
* Johan of ''Manga/{{Monster}}'' is an expert at driving perfectly sane and normal people to suicide through total MoreThanMindControl. From the little that is known of his past, his own sanity was methodically attacked throughout his childhood.
* This is the origin of Tomura Shigaraki from ''Manga/MyHeroAcademia''. [[spoiler:Years of abuse from his father, coupled by him accidentally killing his family, before killing his abusive father on purpose followed by being adopted by All For One and driven by his manipulations, drove him insane and transformed him from Tenko Shimura to Tomura.]]
* In ''Manga/{{Naruto}}'' Tobi's talk with Sasuke about Itachi's true intentions ultimately led to Sasuke becoming AxCrazy and joining Tobi's side.
* Eto's torture and manipulation of Kanae in ''Manga/TokyoGhoul'' was done for the purpose of destroying [[spoiler: her sanity to the point of making her devoted to her and using her as a tool]].

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[[folder:Anime and & Manga]]
* What Akito Sohma did to Kana in ''Manga/FruitsBasket''. ''Manga/ChainsawMan'': After Akito blinded Hatori for asking for permission to marry Kana, Akito turned against Denji defeats The Doll Woman physically, Cosmo destroys her mentally by giving her [[MySkullRunnethOver all the poor nurse and blamed her so much for Hatori's partial blindness that she went mad. It was so bad that Hatori had to [[spoiler: delete Kana's memories of their relationship.]]
** [[spoiler: Ironically, ''Akito'' herself was driven to madness upon years of monstrous psychological abuse coming from her mother Ren. As a little kid, Akito was naive and bad-tempered but not evil; however, she completely SNAPPED and became a massive {{Yandere}} with some
knowledge of the worst issues in the whole cast.]]
* Johan of ''Manga/{{Monster}}'' is an expert at driving perfectly sane
cosmos]], reducing Doll Woman and normal people to suicide through total MoreThanMindControl. From the little her Dolls into wayward husks that is known of his past, his own sanity was methodically attacked throughout his childhood.
* This is the origin of Tomura Shigaraki from ''Manga/MyHeroAcademia''. [[spoiler:Years of abuse from his father, coupled by him accidentally killing his family, before killing his abusive father on purpose followed by being adopted by All For One and driven by his manipulations, drove him insane and transformed him from Tenko Shimura to Tomura.]]
* In ''Manga/{{Naruto}}'' Tobi's talk with Sasuke about Itachi's true intentions ultimately led to Sasuke becoming AxCrazy and joining Tobi's side.
* Eto's torture and manipulation of Kanae in ''Manga/TokyoGhoul'' was done for the purpose of destroying [[spoiler: her sanity to the point of making her devoted to her and using her as a tool]].
can only say "Halloween".



* What Akito Sohma did to Kana in ''Manga/FruitsBasket''. After Akito blinded Hatori for asking for permission to marry Kana, Akito turned against the poor nurse and blamed her so much for Hatori's partial blindness that she went mad. It was so bad that Hatori had to [[spoiler:delete Kana's memories of their relationship.]] Ironically, [[spoiler:''Akito'' herself was driven to madness upon years of monstrous psychological abuse coming from her mother Ren. As a little kid, Akito was naive and bad-tempered but not evil; however, she completely ''snapped'' and became a massive {{Yandere}} with some of the worst issues in the whole cast.]]
* ''Manga/JoJosBizarreAdventure'':
** ''[[Manga/JojosBizarreAdventureBattleTendency Battle Tendency]]'': Straizo was Driven to Madness by his fear of decaying. Witnessing power as a vampire years ago, he mostly sought the "beauty and eternal youth" bit of it as he is afraid of dying as a withered old man.
** ''[[Manga/JojosBizarreAdventureStardustCrusaders Stardust Crusaders]]'': Senator Phillips goes off the handle after being unfortunate enough to encounter DIO, experience [[TimeStandsStill the effects]] of The World, and forced to drive through a sidewalk filled with people, ramming through a lot of them in the way.
** ''[[Manga/JojosBizarreAdventureGoldenWind Golden Wind]]'': This is [[spoiler:Diavolo]]'s final fate. [[spoiler:Upon receiving a thorough CurbStompBattle by Giorno's Gold Experience Requiem, the decisive finishing blow causes Diavolo to be subjected to a [[AndIMustScream never-ending]] ResurrectionDeathLoop, doomed to die repeatedly for eternity. After multiple deaths, he's gone fully insane as he screams at a young girl to stay away from him]].
** ''[[Manga/JojosBizarreAdventureStoneOcean Stone Ocean]]'': In the past, [[spoiler:Weather Report]] was a kind man with a strong sense of justice. However, after [[spoiler:the Ku Klux Klan members that Pucci unwittingly hired nearly beat him to death, strung him up on a tree, and caused his girlfriend to commit suicide, Weather became enraged at the entire world enough to develop [[TheVirus Heavy Weather]], which is why Pucci stole his memories after seeing how dangerous he became]].
* Johan of ''Manga/{{Monster}}'' is an expert at driving perfectly sane and normal people to suicide through total MoreThanMindControl. From the little that is known of his past, his own sanity was methodically attacked throughout his childhood.
* This is the origin of Tomura Shigaraki from ''Manga/MyHeroAcademia''. [[spoiler:Years of abuse from his father, coupled by him accidentally killing his family, before killing his abusive father on purpose followed by being adopted by All For One and driven by his manipulations, drove him insane and transformed him from Tenko Shimura to Tomura.]]
* In ''Manga/{{Naruto}}'', Tobi's talk with Sasuke about Itachi's true intentions ultimately led to Sasuke becoming AxCrazy and joining Tobi's side.
* Eto's torture and manipulation of Kanae in ''Manga/TokyoGhoul'' was done for the purpose of destroying [[spoiler: her sanity to the point of making her devoted to her and using her as a tool]].



* ''ComicBook/TheAvengers:'' The storyline ''The Crossing'' claimed Hank Pym's infamous mental breakdown had been deliberately caused by Immortus. ''ComicBook/AvengersForever'' retconned this out, with one of Immortus' henchmen saying that nope, Hank's breakdown had nothing to do with them.

to:

* ''ComicBook/TheAvengers:'' ''ComicBook/TheAvengers'': The storyline ''The Crossing'' claimed Hank Pym's infamous mental breakdown had been deliberately caused by Immortus. ''ComicBook/AvengersForever'' retconned this out, with one of Immortus' henchmen saying that nope, Hank's breakdown had nothing to do with them.



* ''[[Franchise/{{Batman}} Batman: The Killing Joke]]'': In which The Joker attempts to drive Commissioner Gordon insane and fails.

to:

* ''[[Franchise/{{Batman}} ''[[ComicBook/TheKillingJoke Batman: The Killing Joke]]'': In which The Joker attempts to drive Commissioner Gordon insane and fails.



* ''ComicBook/HowardTheDuck'': Howard suffers a psychological breakdown after encountering with several weirdos at some point. Fortunately, he gets better with the help of Daimon Hellstrom and Dr. Avery (but not before causing a complete chaos while he is accidentally possessed by Hellstrom's demonic soul).



[[folder:Live Action TV]]

to:

[[folder:Live Action [[folder:Live-Action TV]]



* In ''Series/MyNameIsEarl'' the episode "Crazy Witch Lady" has the titular Lady driven to madness by the citizens of Camden treating her like an evil witch. It is implied she was just a regular quirky [[EccentricTownsfolk Camden resident]] before this.
* In ''Series/ThePrisoner1967'' Number 6 goes to work on the Number 2 of the week in "Hammer Into Anvil". (Arguably, breaking Number 6' sanity is the point behind the whole series.)
* Series/StarTrekDeepSpaceNine has this happen to Gul Dukat after he witnesses [[OutlivingOnesOffspring the death of his daughter]], at the climax of a long string of personal and career setbacks. His redeeming features and likable character traits had been submerged by his arrogance and ruthless ambition many episodes previously, but [[AlasPoorVillain it's hard not to pity him]] as he cradles her corpse and mumbles to her in a broken monotone. Dukat eventually comes out of his VillainousBSOD, but becomes steadily more unhinged and [[TheUnfettered even more dangerous for it]], even before he becomes the Bajoran religious equivalent of a DarkMessiah.

to:

* In ''Series/MyNameIsEarl'' ''Series/MyNameIsEarl'', the episode "Crazy Witch Lady" has the titular Lady driven to madness by the citizens of Camden treating her like an evil witch. It is implied she was just a regular quirky [[EccentricTownsfolk Camden resident]] before this.
* In ''Series/ThePrisoner1967'' ''Series/ThePrisoner1967'', Number 6 goes to work on the Number 2 of the week in "Hammer Into Anvil". (Arguably, breaking Number 6' sanity is the point behind the whole series.)
* Series/StarTrekDeepSpaceNine ''Series/StarTrekDeepSpaceNine'' has this happen to Gul Dukat after he witnesses [[OutlivingOnesOffspring the death of his daughter]], at the climax of a long string of personal and career setbacks. His redeeming features and likable character traits had been submerged by his arrogance and ruthless ambition many episodes previously, but [[AlasPoorVillain it's hard not to pity him]] as he cradles her corpse and mumbles to her in a broken monotone. Dukat eventually comes out of his VillainousBSOD, but becomes steadily more unhinged and [[TheUnfettered even more dangerous for it]], even before he becomes the Bajoran religious equivalent of a DarkMessiah.



* ''VideoGame/DarkestDungeon'': This is one of two ways that the enemies can kill your party (the other being relentless murder). The entire dungeon is one big stress-fest, with critical hits that crush morale and enemy attacks solely dedicated to freaking your party out. If they reach the breaking point, they go insane. If they reach the breaking point twice, they'll havea heart attack and be immediately dropped to [[LastChanceHitPoint Death's Door]], or if they already were, they'll die instantly with NoSavingThrow. Good news is, there is a tiny chance that the heroes can [[HeroicSecondWind find clarity in the eye of the storm]], effectively making them even better than normal, but even that can be stripped away with enough stress...

to:

* ''VideoGame/ANNOMutationem'': At The Consortium's research facility, a large red sphere of corrupted energy broke loose and caused the surrounding researchers who were consumed by it to lose all sanity.
* ''VideoGame/ClockTower1995'': The birth of the twins triggered Mary's obsession with black magic and the occult, leading to her sacrificing people for the human flesh her babies needed to survive.
* ''VideoGame/DarkestDungeon'': This is one of two ways that the enemies can kill your party (the other being relentless murder). The entire dungeon is one big stress-fest, with critical hits that crush morale and enemy attacks solely dedicated to freaking your party out. If they reach the breaking point, they go insane. If they reach the breaking point twice, they'll havea heart attack and be immediately dropped to [[LastChanceHitPoint Death's Door]], or if they already were, they'll die instantly with NoSavingThrow. Good news is, there is a tiny chance that the heroes can [[HeroicSecondWind find clarity in the eye of the storm]], effectively making them even better than normal, but even that can be stripped away with enough stress...stress.



--> '''Sheogorath''': ''"Madness is a bitter mercy, perhaps, but a mercy nonetheless. It is better to be seen as mad than hopelessly despondent."''
* In ''VideoGame/{{Ib}}'' the [[CreepyDoll blue dolls]] are capable of driving people insane. Late in the game they attempt to do this to [[spoiler: Garry]] and if they succeed the damage may be [[GetAHoldOfYourselfMan temporary]]..or [[DownerEnding permament]], all depending on your [[MultipleEndings previous actions]].

to:

--> '''Sheogorath''': ''"Madness '''Sheogorath:''' Madness is a bitter mercy, perhaps, but a mercy nonetheless. It is better to be seen as mad than hopelessly despondent."''
despondent.
* In ''VideoGame/{{Ib}}'' ''VideoGame/{{Ib}}'', the [[CreepyDoll blue dolls]] are capable of driving people insane. Late in the game they attempt to do this to [[spoiler: Garry]] and if they succeed the damage may be [[GetAHoldOfYourselfMan temporary]]..or [[DownerEnding permament]], all depending on your [[MultipleEndings previous actions]].



* ''VideoGame/MarkOfTheNinja'': The fate of those who wind up marked by the tattoos, leading to them committing suicide in order to avoid becoming a danger to their clan. This practice was put into place after Tetsuji, the clan's founder, wound up obtaining tattoos of his own to restore his youth and went on a madness-fueled rampage. [[spoiler:The Ninja begins to have this happen to him as well as the game progresses. If he chooses to kill Azai in the ending, he passes the point of no return]].



* ''VideoGame/{{Overwatch}}'' character Sigma was the victim of a FreakLabAccident when attempting to learn to control the power of a black hole. The exposure to the intense gravity altered him, granting him [[GravityMaster power over gravity itself]], but fractured his mind to the point where he's barely cognizant of the world around him.

to:

* ''VideoGame/{{Overwatch}}'' character ''VideoGame/{{Overwatch}}'': Sigma was the victim of a FreakLabAccident when attempting to learn to control the power of a black hole. The exposure to the intense gravity altered him, granting him [[GravityMaster power over gravity itself]], but fractured his mind to the point where he's barely cognizant of the world around him.



* ''VideoGame/TheWedding'': Jack begins to become insane and mentally unstable, the longer the portal in his basement is open. Lack of sleep was part of the reason why the demons and monsters roaming his house made it easier for him to go insane. His notes also indicate that his wife apparently summoned some extra demons, specifically to terrify him, but [[UnreliableNarrator exactly how accurate that is, given Jack's mental state when writing that part]]...

to:

* ''VideoGame/TheWedding'': Jack begins to become insane and mentally unstable, the longer the portal in his basement is open. Lack of sleep was part of the reason why the demons and monsters roaming his house made it easier for him to go insane. His notes also indicate that his wife apparently summoned some extra demons, specifically to terrify him, but [[UnreliableNarrator exactly how accurate that is, given Jack's mental state when writing that part]]...part]].



* [[spoiler:Enzo]] in WebAnimation/Supermarioglitchy4sSuperMario64Bloopers "Birthday Freakout", after [[spoiler:Mario ruins his party by making the castle explode. Ever since then, he has been planning to assassinate Mario. This has been pushed to higher limits [[BigDamnHeroes when a Policeman arrests him]], causing him to plan {{Revenge}}.]]

to:

* [[spoiler:Enzo]] in WebAnimation/Supermarioglitchy4sSuperMario64Bloopers ''[[WebAnimation/Supermarioglitchy4sSuperMario64Bloopers SMG4's Mario Bloopers]]'' episode "Birthday Freakout", after [[spoiler:Mario ruins his party by making the castle explode. Ever since then, he has been planning to assassinate Mario. This has been pushed to higher limits [[BigDamnHeroes when a Policeman arrests him]], causing him to plan {{Revenge}}.]]



* In ''WesternAnimation/TheBatman'', Joker does this to Detective Bennett in a situation clearly inspired by ''ComicBook/TheKillingJoke''. Unlike his comic counterpart, this Joker actually succeeds and turn Bennett into a supervillain.

to:

* ''[[Franchise/AvatarTheLastAirbender Avatar]]'':
** ''WesternAnimation/AvatarTheLastAirbender'': [[spoiler:Princess Azula, who in the span of one summer loses the fear (and love, in her own way) of her best friends, learns her father will never love her no matter what she does, loses the Fire Lord title to Zuko in an Agni Kai, and has her philosophies proven completely wrong to her. Too many blows to the psyche send Azula into a frothing madness in which she's actually developed SplitPersonalities between the manipulative and the lunatic.]]
** The Fog of Lost Souls from ''WesternAnimation/TheLegendOfKorra'' is a prison within the Spirit World for humans. The fog bombards its occupants with images of their greatest fears and failures, slowly driving them mad over the course of decades if not centuries. [[spoiler:Zhao has been reduced to a TalkativeLoon, and Tenzin and his siblings begin to fall to the Fog's effects after only a few minutes of wandering.]]
* In ''WesternAnimation/TheBatman'', Joker does this to Detective Bennett in a situation clearly inspired by ''ComicBook/TheKillingJoke''. Unlike his comic counterpart, this Joker actually succeeds and turn turns Bennett into Clayface.
* ''WesternAnimation/{{Gargoyles}}'': In "Revelations", [[VillainOfTheWeek Mace Malone]] describes [[HellHotel The Hotel Cabal]] was developed as
a supervillain.torture technique to learn the secrets of people of interest. But after losing his only method of shutting down the traps, Mace himself is driven mad as he is forced to endure all manner of torture with every door he opens.
* ''WesternAnimation/TheGrimAdventuresOfBillyAndMandy'': In "Creating Chaos", Eris attempted to have Billy as her apprentice, but his incredibly stupid and inane demands that she's forced to follow (including literally [[AGoodOldFashionedPaintWatching watching paint dry]] for hours) causes her to break down into a whimpering heap by the time he's finally ready to use her apple of chaos.



* The Fog of Lost Souls from ''WesternAnimation/TheLegendOfKorra'' is a prison within the Spirit World for humans. The fog bombards its occupants with images of their greatest fears and failures, slowly driving them mad over the course of decades if not centuries. [[spoiler: Zhao has been reduced to a TalkativeLoon, and Tenzin and his siblings begin to fall to the Fog's effects after only a few minutes of wandering.]]
** The prequel series does this to [[spoiler: Princess Azula, who in the span of one summer loses the fear (and love, in her own way) of her best friends, learns her father will never love her no matter what she does, loses the Fire Lord title to Zuko in an Agni Kai, and has her philosophies proven completely wrong to her. Too many blows to the psyche send Azula into a frothing madness in which she's actually developed SplitPersonalities between the manipulative and the lunatic.]]
* Many WesternAnimation/LooneyTunes characters end up doing this to their antagonists -- of particular note are the mice Hubie and Bertie.

to:

* The Fog of Lost Souls from ''WesternAnimation/TheLegendOfKorra'' is a prison within the Spirit World for humans. The fog bombards its occupants with images of their greatest fears and failures, slowly driving them mad over the course of decades if not centuries. [[spoiler: Zhao has been reduced to a TalkativeLoon, and Tenzin and his siblings begin to fall to the Fog's effects after only a few minutes of wandering.]]
** The prequel series does this to [[spoiler: Princess Azula, who in the span of one summer loses the fear (and love, in her own way) of her best friends, learns her father will never love her no matter what she does, loses the Fire Lord title to Zuko in an Agni Kai, and has her philosophies proven completely wrong to her. Too many blows to the psyche send Azula into a frothing madness in which she's actually developed SplitPersonalities between the manipulative and the lunatic.]]
* Many WesternAnimation/LooneyTunes ''WesternAnimation/LooneyTunes'' characters end up doing this to their antagonists -- of particular note are the mice Hubie and Bertie.


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* ''WesternAnimation/WeBareBears'': In "Tote-Life", the bears succumb to this with their tote bag hoarding, Panda even tries to date one.

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[[folder:Machinima]]
* [[spoiler:Enzo]] in Machinima/Supermarioglitchy4sSuperMario64Bloopers "Birthday Freakout", after [[spoiler:Mario ruins his party by making the castle explode. Ever since then, he has been planning to assassinate Mario. This has been pushed to higher limits [[BigDamnHeroes when a Policeman arrests him]], causing him to plan {{Revenge}}.]]
* In ''Machinima/RedVsBlue'' Season 11, Lopez Dos Point Oh becomes so stunned at how outrageously stupid and inept the Reds are that he hijacks a giant robot and goes on a destructive spree.
-->'''Dos.0''': ''(Spanish Subtitles)'' [...He's insane. ''They're all insane''.]
[[/folder]]



[[folder:Web Animation]]
* [[spoiler:Enzo]] in WebAnimation/Supermarioglitchy4sSuperMario64Bloopers "Birthday Freakout", after [[spoiler:Mario ruins his party by making the castle explode. Ever since then, he has been planning to assassinate Mario. This has been pushed to higher limits [[BigDamnHeroes when a Policeman arrests him]], causing him to plan {{Revenge}}.]]
* In ''WebAnimation/RedVsBlue'' Season 11, Lopez Dos Point Oh becomes so stunned at how outrageously stupid and inept the Reds are that he hijacks a giant robot and goes on a destructive spree.
-->'''Dos.0''': ''(Spanish Subtitles)'' [...He's insane. ''They're all insane''.]
[[/folder]]



[[folder:Web Original]]
* [[VideoGame/HalfLife Gordon Freeman]], in ''Machinima/FreemansMind'', starts to behave more and more erratically as time passes and things happen (not that he wasn't a bit of a CloudCuckooLander to begin with). He has a ''dead serious'' monologue about how he's probably going insane and in need of psychological assistance after it's all over.

to:

[[folder:Web Original]]
Videos]]
* [[VideoGame/HalfLife Gordon Freeman]], in ''Machinima/FreemansMind'', ''WebVideo/FreemansMind'', starts to behave more and more erratically as time passes and things happen (not that he wasn't a bit of a CloudCuckooLander to begin with). He has a ''dead serious'' monologue about how he's probably going insane and in need of psychological assistance after it's all over.

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