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Adding example now that the season 2 trailer has confirmed that Alex is Lex.
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** [[spoiler:Alex, the show's version of Lex Luthor, wears glasses, something his comic self has never been portrayed as needing]].
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->''I've read several different fics where Elsa's in the hospital, or has SOME sort of condition. Cancer, selective mutism, dissociative personality disorder, PTSD, depression, anxiety disorders, bipolar, etc.''
-->-- '''[[https://www.fanfiction.net/r/10387863/0/5/ Wandering Quill]]''', ''Website/FanfictionDotNet''
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* ''VideoGame/SpyroReignitedTrilogy'': A couple of the dragons from ''VideoGame/SpyroTheDragon1998'' were given prosthetic wings in the remake. One dragon also appears to be blind.
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* Andy in ''Film/ChildsPlay2019'' is partially deaf, unlike his original counterpart. [[spoiler: This is done to add tension when Chucky talks to him through his hearing aid.]]
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* Andy in ''Film/ChildsPlay2019'' is partially deaf, unlike his original counterpart. [[spoiler: This [[spoiler:This is done to add tension when Chucky talks to him through his hearing aid.]]
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** In ''Film/IronMan3'', Tony suffers from Post Traumatic Stress Disorder after the events of the ''Avengers'' film. Tony doesn't suffer PTSD in the comics. They allude in the first two films without mentioning it to the disability Tony has in the comics: he's an alcoholic. (Specifically, in ''Iron Man 2'' he becomes an alcoholic because of stress from the fact that he's dying. Both problems are fixed by the climax.)
** In ''Eternals'', Makkari is deaf, like [[GenderFlip her]] [[DisabledCharacterDisabledActor actress]] Lauren Ridloff. In the comics, Makkari has no disability.
** In ''Film/{{Black Widow|2021}}'', Taskmaster is turned from a [[spoiler: male]] mercenary with [[AwesomenessByAnalysis photographic mimicry powers]] to [[spoiler: the daughter of the Red Room's leader, who lost physical mobility when Black Widow attempted to assassinate her father. The Taskmaster suit is what allows her to move and physically mimic her opponents.]]
** In ''Film/AntManAndTheWasp'', Ghost, instead of inventing a suit that turns them intangible, [[spoiler: is affected with quantum instability, which causes her severe chronic pain and will eventually kill her if not cured. The suit helps her control her condition. Like Taskmaster above, this character is also [[GenderFlip gender flipped]].]]
** In ''Eternals'', Makkari is deaf, like [[GenderFlip her]] [[DisabledCharacterDisabledActor actress]] Lauren Ridloff. In the comics, Makkari has no disability.
** In ''Film/{{Black Widow|2021}}'', Taskmaster is turned from a [[spoiler: male]] mercenary with [[AwesomenessByAnalysis photographic mimicry powers]] to [[spoiler: the daughter of the Red Room's leader, who lost physical mobility when Black Widow attempted to assassinate her father. The Taskmaster suit is what allows her to move and physically mimic her opponents.]]
** In ''Film/AntManAndTheWasp'', Ghost, instead of inventing a suit that turns them intangible, [[spoiler: is affected with quantum instability, which causes her severe chronic pain and will eventually kill her if not cured. The suit helps her control her condition. Like Taskmaster above, this character is also [[GenderFlip gender flipped]].]]
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** In ''Film/IronMan3'', Tony suffers from Post Traumatic Stress Disorder after the events of the ''Avengers'' film.''Film/TheAvengers2012''. Tony doesn't suffer PTSD in the comics. They allude in the first two films without mentioning it to the disability Tony has in the comics: he's an alcoholic. (Specifically, in ''Iron Man 2'' ''Film/IronMan2'', he becomes an alcoholic because of stress from the fact that he's dying. Both problems are fixed by the climax.)
** In''Eternals'', ''Film/{{Eternals}}'', Makkari is deaf, like [[GenderFlip her]] [[DisabledCharacterDisabledActor actress]] Lauren Ridloff. In the comics, Makkari has no disability.
** In''Film/{{Black Widow|2021}}'', ''Film/BlackWidow2021'', Taskmaster is turned from a [[spoiler: male]] [[spoiler:male]] mercenary with [[AwesomenessByAnalysis photographic mimicry powers]] to [[spoiler: the [[spoiler:the daughter of the Red Room's leader, who lost physical mobility when Black Widow attempted to assassinate her father. The Taskmaster suit is what allows her to move and physically mimic her opponents.]]
opponents]].
** In ''Film/AntManAndTheWasp'', Ghost, instead of inventing a suit that turns them intangible,[[spoiler: is [[spoiler:is affected with quantum instability, which causes her severe chronic pain and will eventually kill her if not cured. The suit helps her control her condition. Like Taskmaster above, this character is also [[GenderFlip gender flipped]].]]gender-flipped]]]].
** In
** In
** In ''Film/AntManAndTheWasp'', Ghost, instead of inventing a suit that turns them intangible,
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* ''WesternAnimation/StrawberryShortcakeBerryInTheBigCity'': Lime Chiffon is visually impaired and cannot see at all without her glasses, while her previous incarnations didn't. The episode "Following The Recipe" also reveals that Blueberry Muffin is dyslexic, which she never was in her prior incarnations, due to being shown reading something (1980s) or being characterized as a {{Bookworm}} (2003 and ''Berry Bitty Adventures'').
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* "The Doctor's Case" (a Literature/SherlockHolmes story by Creator/StephenKing) gives Holmes a cat allergy to explain why he doesn't solve the murder of a cat owner as quickly as he otherwise would have.
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* ''Series/{{The Gifted|2017}}'': ComicBook/{{Polaris}} is depicted as suffering from bipolar disorder. While her comic book counterpart has suffered some sort of mental disorder, it hasn't been actually specified which one.
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* ''Series/{{The Gifted|2017}}'': ComicBook/{{Polaris}} [[Characters/XMen60sMembers Polaris]] is depicted as suffering from bipolar disorder. While her comic book counterpart has suffered some sort of mental disorder, it hasn't been actually specified which one.
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Can also be as minor as wearing glasses, which is often treated as a purely aesthetic choice.
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* ''Series/Bodies2023'': Maplewood's comic counterpart is an able-bodied amnesiac. In the show, she has all her memories, but is paraplegic and relies on special spinal implants to walk.
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** Quentin Larry Lance suffers from a weakened heart after the battle with Deathstroke and his minions. He has no such illness in the comics (nor did he fight against Deathstroke).
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** Quentin Larry Lance suffers from a weakened heart after the battle with Deathstroke and his minions. He has His comic book counterpart, Larry Lance, had no such illness in the comics prior to his death (nor did he fight against Deathstroke).
