History GameBreaker / HoloCure

* The '''Kusogaki Shackles''' are a game changer of an item that, when fully leveled, completely negates the negative effects brought on by other items. This means that at the cost of one of your item slots you can use risky items like Injection Type Asacoco and Face Mask without having to worry about becoming a GlassCannon. Do note however, that it does ''not'' work on the Halu.
* The '''Beetle''' is a powerful item that boosts the damage potency of character skills by 100% at max level, increasing further by 1% per character level. With this item, certain character skills that deal damage become even deadlier (Aki's Belly Dance, Ollie's Zombie Jutsu, and Moona's Lunar Rabbit to name a few), and can contribute to even higher DPS. Its potent power boost is well worth the difficulty in unlocking it (clear a stage with ''no'' character skills learned).

** '''Tokino Sora''' can easily be described as '[=IRyS=] 2.0' due to the insane amount of healing she is capable of. Her special heals her for a small amount every time it hits an enemy, and teamed up with her Idol Healing skill can melt through dense packs of enemies. With Full Meal and a maxed out Piki Piki Piman, Sora can loop her special almost nonstop and heal faster than most enemies can hurt her. 0.5 slightly nerfed her special by reducing healing on hit to a 50% proc rate. 0.6 put an end to special loop antics with changing Piki Piki Piman's effect but on the flip side, the introduction of Jingisukan enables her to basically stack its damaging effects with her Idol Healing.

* The '''Candy Kingdom Sweets''' inflicts a ''negative'' damage multiplier of 0.75, which might not seem very good at first glance. In exchange however, it also grants up to a massive '''60%''' boost to haste, greatly boosting attack speed for all weapons. Additionally, there is a 10% chance for every attack to deal an additional hit worth 33% of its base damage, which adds up very quickly. The greatly hastened rate of fire for all weapons more than makes up for the negative damage multiplier, and there are ways to get around it such as the Gorilla's Paw listed above. Like the Beetle, its incredible power is well worth the difficulty in unlocking it (level up haste 10 times in a single run).

* Following her buffs in 0.6, '''[=AZKi=]''' went from a fairly weak character to one of the best, if not ''the''best, coin farmers in the game, beating out even [=IRyS=]. She comes with a decently strong early game with her "Encore!" skill, sending out a damaging wave every 7 seconds, growing in potency based on how many enemies she kills within those 7 seconds. She also has with "Virtual Diva" and "Performance", the former boosting her attack speed, the latter enhancing her movement speed and dodge rate. However, her main draw is none of these skills, but rather her main weapon, Diva Song, which when maxed out has a 75% chance to split into 2 musical notes that also pierce through enemies. As of 0.6, these sub-notes can '''also''' trigger Stamps, and crucially, each individual hit from this weapon deals much more damage than those from [=IRyS=]'s rapid-fire beam. When combined with the reworked Greed Stamp (the output of which now depends on damage) and the Bomb Stamp, this results in massive amounts of coins. Played optimally, [=AZKi=] can easily farm ''millions'' of Holocoins in a single Endless run! As Diva Song also hits quite hard, [=AZKi=] is no slouch in Stage Mode, combining her great speed with potent killpower that rips through mobs easily.

* Following her buffs in 0.6, '''[=AZKi=]''' went from a fairly weak character to one of the best coin farmers in the game, beating out even [=IRyS=]. She comes with a decently strong early game with her "Encore!" skill, sending out a damaging wave every 7 seconds, growing in potency based on how many enemies she kills within those 7 seconds. She also has with "Virtual Diva" and "Performance", the former boosting her attack speed, the latter enhancing her movement speed and dodge rate. However, her main draw is none of these skills, but rather her main weapon, Diva Song, which when maxed out has a 75% chance to split into 2 musical notes that also pierce through enemies. As of 0.6, these sub-notes can '''also''' trigger Stamps, and crucially, each individual hit from this weapon deals much more damage than those from [=IRyS=]'s rapid-fire beam. When combined with the reworked Greed Stamp (the output of which now depends on damage) and the Bomb Stamp, this results in massive amounts of coins. Played optimally, [=AZKi=] can easily farm ''millions'' of Holocoins in a single Endless run!

While most weapons are generally used to combine collabs, a few weapons in particular stand out for being quite powerful even on their own.

* '''EN's Curse''' fires off curses that have a high chance to chain to another target. At max level, for every time the curse chains, its damage increases by 10% with no cap to how high it can go. Within a huge horde of enemies, this makes EN's Curse capable of reaching damage in the ''thousands'' quite easily. It's a very good choice for your final weapon late in a run, if you aren't using it for Eldritch Horror.

** '''Eldritch Horror''' (Spider Cooking + EN's Curse), previously seen as an underwhelming collab, has been RescuedFromTheScrappyHeap and '''buffed''' at the same time most others have been nerfed into the ground, making it now stand very far above the rest. Just about the only thing holding it back from being a must-have in every run is that it competes for one of its components with the powerful Super Collab Jingisukan.