History DelicateAndSickly / AnimeAndManga

** Also voiced by Creator/AiOrikasa as the previous example: [[ChildProdigy Hiroki Sawada]] of the NonSerialMovie ''The Phantom of Baker Street'' -- but [[InformedFlaw not at all related to the plot]]. [[spoiler: And that's not [[IntelligenceEqualsIsolation what kil]][[DrivenToSuicide led him]], either, but definitively adds to his WoobieDestroyerOfWorlds status.]]

** The whole sixteenth movie, ''The Eleventh Striker'', had one of these as motivation: [[spoiler: The BigBad and AntiVillain was a man who had an IntergenerationalFriendship with an ill boy named Tomofumi Motoura. Poor Tomofumi who died years ago when he was in need of medical attention but a soccer mob stopped the ambulance he was in and prevented the medical staff to save his life. (And a drunk Kogoro was a member of said mob, too.) So the BigBad became a MadBomber hell-bent on revenge against both Kogoro and anything related to soccer...]]

* In ''Manga/BlackButler'', Ciel's MissingMom Rachel Durless was asthmatic and passed her illness on [[IllBoy her son]]. Her sister Angelina aka the future "Madame Red" got the idea of becoming a doctor from her desire to help Rachel with her health problems.

** In the backstory, there is another: [[spoiler:Black Jack's own mother, who was severely injured in the same incident that left him as an IllBoy and died few months later.]]

** We meet [[ElegantClassicalMusician Hijiri Minase]] when he has just ''stopped'' being an IllBoy, having had a cornea transplant to fix his eyesight. [[DealWithTheDevil And then things go]] FromBadToWorse.

** [[PrinceCharming Yuki]] was an IllBoy when he was little, too, as evidenced by his [[IncurableCoughOfDeath persistent cough]]. It's mainly just asthma, though, which he eventually outgrows.

** And his IllBoy condition is spoofed ''mercilessly'' in the [[FunSize Chibi episodes]], where he collapses and dies every five seconds much to Sanada's despair. [[SayMyName "YUKIMURAAAAAAAAAAA!!!!!"]], indeed.

* In ''LightNovel/AscendanceOfABookworm'', Maine is a peasant girl who looks younger than her actual age due to constantly getting sick. She has no stamina, little strength and is highly prone to fevers. As such she typically needs to get other people to do physical labor for her to actually make things and, even setting that aside, is subject to a mysterious fever that could easily kill her the moment she lets her guard down.

** Also voiced by Creator/AiOrikasa as the previous example: [[ChildProdigy Hiroki Sawada]] of the NonSerialMovie ''The Phantom of Baker Street'' -- but [[InformedFlaw not at all related to the plot]]. [[spoiler: And that's not [[IntelligenceEqualsIsolation what kil]][[DrivenToSuicide led him]], either.]]

* August Riefelstahl in ''LightNovel/EndoAndKobayashiLiveTheLatestOnTsundereVillainessLieselotte''. He's quite old compared to this trope's norm--he died at 24 and it was the last year of his life that is plot relevant. He's always been in frail health, but the fact that his younger brother Bruno has an ({{Inverted|trope}} case of) BigBrotherInstinct on him implies he is indeed considered delicate in-universe.

* August Riefelstahl in ''LightNovel/EndoAndKobayashiLiveTheLatestOnTsundereVillainessLieselotte''. He's quite old compared to this trope's norm--he died at 24 and it was the last year of his life that is plot relevant. He's always been in frail health, but the fact that his younger brother Bruno has an ({{Inverted|trope}} case of) BigBrotherInstinct on him implies he is indeed considered delicate in-universe.

* [[NoNameGiven Tomokane's older brother]] in ''Manga/GAGeijutsukaArtDesignClass''. He apparently spent more time in the nurse's office than his own classroom, to the level that teachers fear his attendance would be the major obstacle in college admissions. He and his {{Bokukko}} younger sister make an ([[SiblingRivalry uncordial]]) example of SiblingYinYang.
** He also [[ExploitedTrope exploits]] this trope to avoid punishment from, say, mentally bullying his sister as he's often seen to be too frail to be physically punished.

* ''Anime/LuckyStar'':
** Kanata, Konata's mom and Soujiro's wife, apparently died in a very Ill Girl way early. That, and the couple being {{childhood friend}}s, Kanata being [[OlderThanTheyLook older than she looked]], made [[GenreSavvy Konata]] wonder if the whole thing is a DatingSim plot. Kanata's [[OlderThanTheyLook super youthful looks]] ''are'' related to the disease, so [[OlderThanTheyLook Konata]] ''may'' fall victim to the same disease... (At least one rather absurd DarkFic {{Doujinshi}} had her develop into a suicidally depressed college student living in fear of her possible demise.)
** [[CheerfulChild Yutaka]], Konata's ''paternal'' cousin, has recurring (albeit mild) health problems that make it difficult for her to keep up with her friends -- she was nearly rendered a BrokenBird from the social isolation caused. And her case of OlderThanTheyLook is even more severe than Kanata's...

* In ''Anime/ThreeThousandLeaguesInSearchOfMother'' (and the story that was its basis), one of the reasons why [[KidHero Marco Rossi]] is so desperate to find his mother Anna is that her last letter implies that her health's is decaying. Which means she might never come back home. [[spoiler: When Marco finally finds her, she's so ill and so depressed that she's rejecting one last operation that could save her life, despite the pleas of her doctor and her benevolent bosses. Seeing Marco again gives Anna the strength to go through the surgery, and she's saved.]]

* Hayate Yagami in ''Anime/MagicalGirlLyricalNanohaAs''. [[spoiler:However, in the sequel series ''[=StrikerS=]'', she is completely healthy. This because her "illness" was actually the curse of the Book of Darkness, so once the Book was destroyed she was able to recover.]]

* In ''LightNovel/EndoAndKobayashiLiveTheLatestOnTsundereVillainessLieselotte'', August, Lieselotte's uncle[[spoiler: and Fiene's father]], has always been sickly since birth, and by the age of 16,[[spoiler: i.e. the age when he and and Elizabeth could have legally married,]] he's already too weak to get out of his bed.

* In ''LightNovel/EndoAndKobayashisLiveCommentaryOnTheVillainess'', August, Liselotte's uncle[[spoiler: and Finne's father]], has always been sickly since birth, and by the age of 16,[[spoiler: i.e. the age when he and and Elizabeth could have legally married,]] he's already too weak to get out of his bed.

** Trafalgar Law was gravely ill for most of his childhood, due to the Amber Lead Syndrome (a illness similar to asbestos that killed Law's family and people due to the World Government's negligence). Law was the SoleSurvivor of his town and was so broken by it that he became a CreepyChild, whose only wish was to kill as many people as possible before dying. Doquixote Doflamingo took Law in and, in EvilMentor style, raised him as a killer -- but Doflamingo's younger brother Rocinante took pity on Law and traveled all over to find him his cure, despite Law trying to kill him when they met. He succeeded and got Law to eat the Ope-Ope Fruit, which saved his life... [[spoiler: but wasn't fast enough to save ''his'' own life, and died at the hand of his cruel older brother (who not only wanted the Ope-Ope Fruit for his own gain, but was ''already'' pissed off after finding out that Rocinante was TheMole for the Marines). This was terrible for the now healthy Law, who had grown to love [[BigBrotherMentor Rocinante]] like an older brother, and ultimately gave him his biggest purpose in life: to become a pirate '''and kill Doflamingo'''. He and Luffy don't get to kill him -- but they '''''do''''' dismantle his evil empire, reveal his deals to the world and defeat him in a massive fight, which may cont as a FateWorseThanDeath.]]

* Kosumo Koganehara from Creator/MichiyoAkaishi's ''Manga/TowaKamoShirenai'' was born with a [[HeartTrauma a weak heart]], and in fact the manga starts when she has a seizure during her treatment in the USA and needs an urgent transplant, but her extremely rare blood type doesn't allow for an easy one. The donor that saves her life just ''happens'' to be Himiko, a {{Miko}} and MagicalGirlWarrior who has just died via an HeroicSacrifice to save a child, so Kosumo inherits her powers alongside her heart and blood and must take up her demon slaying mission - with the help of Himiko's TallDarkAndHandsome guardian, Hitsuji.

** Kaori Miyazono is one as well. It's first hinted in Episode 4 (when she collapses after her performance) and further shown in episode 9, when a lot of pills can be seen in her bag. [[spoiler:Then in episode 15, her legs give out in the middle of the hospital hallway at night. And in Episode 16, her arms can't hold up her bow or, at the very least, a bottle of juice Kousei hands her]]. While her disease is unnamed, it's explained that she will lose control of her legs and her limbs and suffer from seizures that will lead to heart failure; most fans have suspected that due to the symptoms, she [[spoiler: and probably Saki too]] suffered from [[http://www.alsa.org/ Amyotrophic Lateral Sclerosis aka ALS.]] [[spoiler: And Kaori dies from the illness too.]]

* After's Kamille Bidan {{Heroic BSOD}} at the end of ''Anime/MobileSuitZetaGundam'' [[spoiler: as a product of Scirocco's massive MindRape]], he remains in a vegetative state throughout the sequel, ''Anime/MobileSuitGundamZZ''. The few times he's more or less awake, he [[TheOphelia acts very erratically]] and occasionally uses his Newtype powers to call out to other characters such as Judau. [[spoiler: He successfully recovers at the finale.]]
* In ''Manga/CeresCelestialLegend'', Chidori's little brother Shota is hospitalized when introduced.

** Captain Jushiro Ukitake has been suffering from tuberculosis all his life, which makes him spew blood if he exerts himself too much, turned his hair white, and causes him to spend most of his time in bed. (Although since he's over two thousand years old, it's obvious he isn't dying from it... Unless he's dying ''very, very slowly''). [[spoiler: 616 explains that he ''should'' have died when he was young, but thanks to his parents's please to a local god named "Mimihagi-sama", he survived... but in exchange for his life, his lungs suffered badly. Hence, the IncurableCoughOfDeath and BloodFromTheMouth he's been plagued with ''through all his life''.]]
** [[spoiler: As Nodt from the Vandenreich]] turns out to have been this in the past. [[spoiler: A flashback reveals that before he met Yhwach, he was but an ill bedridden man, barely able to breathe and fearfully awaiting his death [[FateWorseThanDeath while simultaneously proclaiming how he hates living like that.]] When Rukia finally slays him with her Bankai, his last thoughts are filled with this old fear.]]
* Oddly enough, Mai Tokiha's brother Takumi from ''Anime/MyHime'' and ''Anime/MyOtome'' manages to fit this trope while also being a domestic type (at least in the former show), and is inordinately fond of his older sibling.
* ''Manga/ThePrinceOfTennis'' has Rikkaidai captain Seiichi Yukimura. Ironically, his slender frame and long hair [[{{Bishonen}} give Yukimura an almost feminine outlook]]. [[spoiler: And when he gets better, he's revealed to be [[YamatoNadeshiko the gentlest, politest and more softspoken person]] outside of the courts... and a KnightTemplar MagnificentBastard [[BewareTheNiceOnes inside of them]].]]
** A further subversion is that Yukimura does in fact have a specific illness (Guillain-Barré syndrome, a disease of the nervous syndrome) which led to some fan complaints after [[spoiler:he recovered, [[ArtisticLicenseMedicine because this condition is incurable.]]]] It's later handwaved in an author's note, apparently: he does ''not'' suffer from Guillain-Barré, but from a similar illness... which is not mentioned by name.
** And his IllBoy condition is spoofed ''mercilessly'' in the [[FunSize Chibi episodes]], where he collapses and dies every five seconds much to Sanada's despair. [[SayMyName "YUKIMURAAAAAAAAAAA!!!!!"]], indeed.
* Son Goku himself for most of the Android Saga in ''Franchise/DragonBall'' gets sick with the heart virus a [[SoapOperaDisease unexplained disease]] that can weaken and kill even a [[HumanAliens Saiyan]] like him. In the worst timing, Goku starts feeling the effects just as he’s fighting the new Android threat and has to be saved by Vegeta when the pain in his chest weakens him to point where he can’t fight. Goku then spends most the saga in agony in bed with a despairing Chi-Chi looking after him, thankfully thanks to Future Trunks to providing a antidote from his future Goku is saved and eventually recovers... [[spoiler: before dying (again) in a HeroicSacrifice to stop Cell blowing up the Earth]].

* Prayer Reverie of ''[[Manga/MobileSuitGundamSEEDAstray Gundam SEED X Astray]]'', who'd almost count as a LittlestCancerPatient if he weren't capable of hopping into a HumongousMecha and kicking ass.
* Hayate Gekko from ''Manga/{{Naruto}}'', who looks pale and sickly and has a huge IncurableCoughOfDeath. Again, he died, but his illness isn't the cause. [[HeKnowsTooMuch He heard the plans of Orochimaru and the Sunagakure people]] and paid for it.
** A villainous example is Kimimaro Kaguya from the Sound Five. It's implied to be [[IncurableCoughOfDeath tuberculosis or something similar]], as he coughs a lot and has a very shortened lifespan.
** Likewise [[spoiler:Itachi Uchiha]], afflicted with an unspecified illness that gives him BloodFromTheMouth.
* Played with in ''Anime/UFORoboGrendizer''. Duke Fleed/Daisuke Umon is an Ill Boy [[spoiler: who's actually dying of radiation poisoning]]... and the ''lead character''
* ''Anime/FistOfTheNorthStar'':
** Toki is incredibly sickly due to radiation poisoning he received sacrificing himself to get Kenshiro and his fiancée Yuria into the nuclear bunker in time before the bombs hit. Despite his condition Toki is still surprisingly capable of kicking ass as a WeakButSkilled fighter, and would’ve been the successor to the Hokuto Shinken had he not become ill.
** [[spoiler: Rei becomes this after BigBad Raoh strikes his Shinketsushū vital point giving him three agonising days left to live. Determined to go out in style, Rei has the aforementioned Toki painfully extend his life for one more day allowing him to avenge his LoveInterest Mamyia by killing her former [[SexSlave captor]] Yuda and succeeds in doing so before succumbing to his fate]].

* ''Anime/SailorMoon S'':
** Luna's sort-of temporary love interest in the movie (and in a side-story of the [[Manga/SailorMoon manga]]) was an ill boy HotScientist named Kakeru Ohzora. The MacGuffin of the movie (a crystal belonging to the BigBad, Princess Kaguya), which is in his possession, saps his LifeEnergy away as the movie passes - he starts relatively healthy, then starts to cough and later is weakened and bedridden. [[spoiler: He gets better]]
** In the manga story on which the movie was based Kakeru was a legitimate ill boy with heart disease.
** Mamoru Chiba spent the last part of the Super S season as an ill boy as [[spoiler: the Dead Moon Circus takes over ther Earth more and more, which causes him great physical pain and weakness since, as Prince Endymion, he's the equivalent of SailorEarth. When the Circus is banished away, he gets better]].
* The ''Manga/IkkiTousen'' manga has [[spoiler: Kakuka from Kyoushou High's PowerTrio, who is healthy in the anime.]] Also, [[spoiler: Ryoumou's UnluckyChildhoodFriend Teifu]] is a ''crippled AND blind'' boy.
* Kenneth "Ken" Robbins from ''Anime/KaleidoStar''. His dream was to participate in the Kaleido Stage as one of the acrobats, but since he got a weak heart, he mostly does staff job. Later in the series, he does some acting as well, but not with any life-risking acrobacies.
* Subverted in ''Anime/CodeGeass R2''. Lelouch's opponent and later ally Li Xingke has an IncurableCoughOfDeath and might not live for long, but remains an excellent pilot and strategist. [[spoiler: He makes it to the end of the series, but it's hinted that he may have passed away after the Zero Requiem.]]
* ''Anime/MobileSuitGundamThe08thMSTeam '' has Ghinias Saharin as an ''Ill'' ''MadScientist''. It's not mentioned what he has, but considering his sympthoms, a popular {{fanon}} theory is that he has [[http://en.wikipedia.org/wiki/Hepatolenticular_degeneration Wilson's disease]].
* Another adult ill boy is Kenshin's BigBrotherMentor Takasugi Shinsaku, from the ''Anime/RurouniKenshin'' ''Tsukiokuhen'' OAV. Based on [[http://en.wikipedia.org/wiki/Shinsaku_Takasugi the Real Life samurai of the same name]], who ''also'' was an ill boy. Both were affected with tuberculosis, and RK!Takasugi was almost in the last stages of his illness when he finds and recruits Kenshin into the Ishinshishi group, proved by his '''nasty''' and bloody cough. [[spoiler: Neither the real nor the fictional Takasugi lived enough to see the beginning of the Meiji restoration.]]
** In the original series we have Kenshin and Saitou's old rival Souji Okita, the most badass member of UsefulNotes/TheShinsengumi -- who ''also'' has tuberculosis and is seen coughing his lungs off. Just like Takasugi, [[http://en.wikipedia.org/wiki/Souji_Okita he was based on a real life figure]] affected by such an illness. [[spoiler: And again, just like Takasugi and his own RL counterpart, Okita died before the Restoration.]]
* Romeo's commoner friend Petruccio from ''Anime/RomeoXJuliet'', afflicted with what's all but stated to be turberculosis. [[spoiler: He dies in Romeo's arms in the same episode he's introduced. ]]
* In ''Anime/AfterWarGundamX'' we have [[spoiler: Caris Nautilus]], a WellIntentionedExtremist who made a sort-of DealWithTheDevil to [[spoiler: become an artificial Newtype, including going through horrible experiments that give him massive PsychicPowers but completely warp his mind and body]]. It goes really, ''really'' bad for him.

* Subverted and parodied mercilessly by the manga-only character of Densuke in ''Manga/RanmaOneHalf''. He is a sickly, bedridden boy who muses that he will die by the time the last persimmon falls from the tree outside his window... cue female Ranma coming by with a huge sack to pick all the persimmons herself. Densuke's illness is never specified, however, he is relatively healthy (if abnormally weak) and all it would take to cure him is a single dose of a powdered medicine. He refuses to take it, though, unless [[IntimateHealing delivered mouth-to-mouth by a pretty nurse]].
** Parodied earlier in both the Manga and the anime by the "ill boy" who insisted on keeping Genma (in his Panda form) as a pet. It turns out he isn't sick, just lazy (and spoiled.)
* ''Manga/CaseClosed'' has several:
** [[CuteClumsyGirl Eisuke Hondou]]'s important [[{{Backstory}} backstories]] were all when he was hospitalized; first due to leukuemia and then due to accident. In the first case, he was saved due to his older sister's marrow donation, [[spoiler: which changed his blood type and tipped Conan/Shinichi off in regards to said sister's own identity and role.]]
** [[spoiler: Seiji Asou]] from the [[spoiler: Moonlight Sonata]] case used to be this as a young boy. In fact, when he was hospitalised in Tokyo, his family (including his father, a famous pianist) was killed in strange circumstances, related to the authorities from the island he grew up in and the shady dealings they had with his dad. For the rest of the story, see [[spoiler:HarmlessLadyDisguise]].
** Also voiced by Creator/AiOrikasa as the previous example: [[ChildProdigy Hiroki Sawada]] of the NonSerialMovie ''The Phantom of Baker Street'' -- but [[InformedFlaw not at all related to the plot]]. [[spoiler: And that's not [[IntelligenceEqualsIsolation what kil]][[DrivenToSuicide led him]], either.]]
** In a filler case, the Detective Boys and Conan go to an hospital to visit their classmate Jun Kataoka, who is so ill that he'll have to stay hospitalised for weeks. Since Jun is also Conan's IdenticalStranger, at the Detective Boys's suggestion they swap clothes and places for a day. [[spoiler: And then Conan is abducted by a mysterious man who wants to blackmail Jun's ''very'' rich widowed father and [[ParentWithNewParamour his soon-to-be stepmom]], but he manages tp escape. And ''then'', the kidnapper appears dead...]]
** The whole sixteenth movie, ''The Eleventh Striker'', had one of these as motivation: [[spoiler: The BigBad and AntiVillain was a man who had an IntergenerationalFriendship with an ill boy named Tomofumi Motoura. Poor Tomofumi who died years ago when he was in need of medical attention but a soccer mob stopped the ambulance he was in and prevented the medical staff to save his life. (And a drunk Kogoro was a member of said mob, too.) So the BigBad became a MadBomber hell-bent on revenge against both Kogoro and anything related to soccer...]]

* [[spoiler:Lasse Aeon]] from ''[[Anime/MobileSuitGundam00 Gundam 00]]'' was healthy in the first season, but in the second one he had quite the IncurableCoughOfDeath. It's apparently a consequence of [[spoiler: his battle with Alejandro Corner.]]
* ''Anime/DenNohCoil'', which seems to enjoy gender-flipping a number of traditional shonen anime roles, has a sick boy in the form of Harakawa Kenichi aka "Haraken." He suffers from fainting spells and some kind of poorly-defined heart flutter that [[spoiler: may or may not have to do with his investigations into the mysterious Illegals.]]
* ''Webcomic/HetaliaAxisPowers'':
** England takes up the role briefly in the episodes featuring TheGrimReaper.
** Spain, when his economy is in a ''terrible'' state and he gets a cold because of it.
** According to WordOfGod, Austria spent some years in a wheelchair. It's not explained ''when'' this happened, but {{fanon}} speculates that it may have taken place either after the dissolution of the Austro-Hungarian Empire or right after UsefulNotes/WorldWarII.
** The ''Manga/HetaliaBloodbath2011'' brings another one: [[spoiler:the pre-teen Holy Roman Empire. He's fflicted with [[IncurableCoughOfDeath a dangerous cough]] and BloodFromTheMouth, and he's so weakened that Hungary has to carry him in her arms]].
* Dr. Kuro Hazama aka the title character of ''Manga/BlackJack'', thanks to [[LandMineGoesClick the hidden field mine that went BOOM on him and his mom]], killing Mrs. Hazama and severely injuring him. Of coruse, he also attends many ill boys and girls as well; in fact, regular character Sharaku was introduced as one in the newest series, since he and his sister Wakou join the cast after BJ has to operate on him in the first episode.
* Suzu's best friend Seishuu in ''Literature/TheTwelveKingdoms'' got a head injury as a little child, in the same incident with monsters that got his mother killed. As a consequence, he sustained brain damage and suffers constant headaches. [[spoiler: He later [[HeroicRROD goes blind as a side-effect]], which gets him killed when [[LookBothWays he cannot see a carriage going towards him and gets hit point-blank]].]]
* Masataka's little brother Mitsugu from ''Manga/SakuraGari''. He was born with a weak heart, barely survived Spanish influenza in the past, and in-series he gets pneumonia. [[ButtMonkey Ouch.]]
* Kyousuke Kamijou from ''Anime/PuellaMagiMadokaMagica'' was a talented violinist involved in an accident, thus we meet him in the hospital and see that not only his arm was injured to the point that he won't be able to play anymore, but he must go through painful therapy to regain use of his legs. The manga goes further by [[GoodScarsEvilScars directly showing the horrible scars on his arms.]] [[spoiler: Sayaka Miki, Madoka's best friend who fancies Kamijou, becomes a MagicalGirl and uses her wish to heal him so he can play again. Unfortunately, Sayaka's motive for healing him was [[SecretlySelfish anything but selfless]] and she is driven to despair when she can't summon up the courage to confess to him, resulting in her becoming a witch soon after Hitomi Shizuki confesses to him instead.]]
* Sho from ''Anime/{{Arrietty}}''. He tells Arrietty he has always been ill and can't play with other kids. The reason he is currently staying at his aunt's place is because he is getting an operation on his heart.
* ''VisualNovel/ABridgeToTheStarrySkies'' has two of these: one is the protagonist's little brother and the other a random village kid.
* Friederich [[spoiler:Brandel]] from ''Manga/HonooNoAlpenRose'' [[spoiler:aka Jeudi's DisappearedDad. In a subversion, a good part of his horrible health comes as a consequence of a terrible accident he was involved into... and he ''dies'' of it, right after having been reunited with Jeudi.]]
* Michio Yuki from ''Manga/{{MW}}''. Not only the titular chemical warfare turned him into an asshole beyond redemption, but also gives him occasional headaches, getting hospitalized at one point, and only a few years left to live.
* Yayoi from ''Manga/{{Loveless}}'', which seems to be the result of severe athsma.
* ''Anime/HeartCatchPrettyCure'' has a very interesting case -- Itsuki Myoudouin's older brother Satsuki is a case of Ill Boy ''and'' a HeirToTheDojo. With him sick, Itsuki's determined to take over their grandfather's dojo, leading her to become a WholesomeCrossdresser because she thinks she won't be taken seriously otherwise. It isn't until halfway through the series that Satsuki goes through an operation and is cured (though it's a pretty risky surgery that could've potentially killed him), leading to Itsuki to start abandoning her role, openly embrace her love for more girlish things and be the [[SixthRanger Third Precure]].
* Three male characters in ''Literature/{{Another}}'' have this. Our protagonist Kouichi Sakakibara has pneumothorax ([[http://en.wikipedia.org/wiki/Pneumothorax collapsed lung]]),[[spoiler:and he's hospitalized due to it for almost a month at the start of the story, making him miss his first day at [[NewTransferStudent his new school]] and thus missing several details about what will go on]]; Ikuo Takabayashi has [[HeartTrauma a heart condition]] [[spoiler:[[KilledOffForReal and it takes away his life]]]], and Daisuke Wakui is asthmatic.

** Trafalgar Law was gravely ill for most of his childhood, due to the Amber Lead Syndrome (a illness similar to asbestos that killed Law's family and people due to the world Government negligence). Law was the SoleSurvivor of his town and was so broken by it that he became a CreepyChild, whose only wish was to kill as many people as possible before dying. Doquixote Doflamingo took Law in and, in EvilMentor style, raised him as a killer - but Doflamingo's younger brother Rocinante took pity on Law and traveled all over to find him his cure, despite Law trying to kill him when they met. He succeeded and got Law to eat the Ope-Ope fruit, which saved his life... [[spoiler: but wasn't fast enough to save ''his'' own life, and died at the hand of his cruel older brother (who not only wanted the Ope-Ope fruit for his own gain, but was ''already'' pissed off after finding out that Rocinante was TheMole for the Marines). This was terrible for the now healthy Law, who had grown to love [[BigBrotherMentor Rocinante]] like an older brother, and ultimately gave him his biggest purpose in life: to become a pirate '''and kill Doflamingo'''. He and Luffy don't get to kill him - but they '''''do''''' dismantle his evil empire, reveal his deals to the world and defeat him in a massive fight, which may cont as a FateWorseThanDeath.]]

* [[spoiler:Coach Jin Munakata]] from ''Manga/AimForTheAce''. The reader knows what he has: [[spoiler:leukemia]]. [[spoiler:And unlike others, he actually ''dies''.]]
* Nikaidou from ''Manga/MarchComesInLikeALion''. He has an unspecified illness that often manifests in the form of anemia. It's frequently mentioned by members of the cast, and is something of a minor sub-plot involving him.
* In ''Manga/{{Bokurano}}'', [[BigBrotherMentor Kunihiko Moji]]'s best friend Nagi is an ill boy with a weak heart and is hospitalised when the plot rolls in. [[spoiler: Moji, who has signed up to pilot a HumongousMecha PoweredByAForsakenChild, wants his own heart to be harvested and given to Nagi for a transplant once he kicks it. This is fulfilled and Nagi gets better.]]
* In ''Manga/MyHeroAcademia'', the world's greatest hero All Might is, in secret, barely able to use his powers after a debilitating injury he got fighting one particularly powerful villain, costing him his stomach and half of his respiratory system. He ends up [[BloodFromTheMouth coughing up blood]] when he overuses his powers, forcing him to use them for only a short while each day, and his true form is highly emaciated as a result of his injury.
* Even in the afterlife, Hisoka Kurosaki from ''Manga/DescendantsOfDarkness'' encounters side-effects from his empathy (being in large crowds and/or [[MindRape witnessing a particularly gruesome vision]]) and [[spoiler:curse marks]] (whenever [[spoiler:Muraki aka the one who raped, cursed AND killed him]] is nearby). He is also extremely sensitive to the sun and [[CantHoldhisLiquor he can't hold his liquor well at all.]]
** We meet [[ElegantClassicalMusician Hijiri Minase]] when he has just ''stopped'' being an IllBoy, having had a cornea transplant to fix his eyesight. [[DealWithTheDevil And then things go]] FromBadToWorse.
* Eagle Vision from ''Manga/MagicKnightRayearth'' has overused Autozam technology (powered by mental energy), giving him anemia-like symptoms. [[spoiler:He later reveals that he is dying from it, but he starts to recover in Cephiro in the manga.]]
* Mikoto Saijou from ''Manga/SaijouNoMeii'' was this, and then was operated on succesfully. Ever since then, he's been working hard to become trhe best child surgeon ever.
* In ''Anime/FatePrototype'', the preliminary version of ''VisualNovel/FateStayNight'', there is Isemi [[spoiler: aka the Third Master.]] [[spoiler: He's a bed-ridden pre-teen boy, kept alive only by medical machinery after having been subjected to horrible experiments. Isemi uses his Command Spells to fully incarnate Rider in this world right before dying, and after he kicks it Rider wants to use the Grail to revive him.]]
* ''Anime/VariableGeo'' [[SoapOperaDisease never specifies what illness]] Daisuke suffers from. All that's known is, he has a hacking cough and occasional seizures that are severe enough to keep him hospitalized. But just as his condition shows signs of improving, [[NebulousEvilOrganization The Jahana Group]] causes it to relapse, in order to pressure his sister, [[{{deuteragonist}} Satomi.]] They offer to cover the cost of the procedure needed to cure Daisuke, [[AnOfferYouCantRefuse on the condition Satomi signed up for the VG tournament...]] [[SympatheticSentientWeapon as their test subject.]]
* ''Anime/PhantomQuestCorp'': Bosco is [[FriendlyNeighborhoodVampire a vampire]] who's trying to kick the habit[[note]]in order to be with [[SingleWomanSeeksGoodMan Makiko]], a 19 year old college freshman that he's fallen in love with[[/note]]. So [[WillfullyWeak he limits himself to only feeding 4 times a year, at only 200cc's per quarter]] while taking supplement tablets in between. Which has taken its toll on his health, leaving him anemic and severely weakened. In his brief tussle with [[OccultDetective Ayaka]], he was only able to hold her off for a few seconds, before he exerted himself and fainted.
* In the manga ''Manga/TheGentlemensAlliance'', the real Shizumasa Togu was an ill boy and being unable to attend school he makes his twin brother go in his place. Later chapters reveal that Shizumasa had Leukemia and had been refusing to get a life saving bone marrow transplant as he wants to die so that his twin Takanari can take his rightful place as the family heir (their family holds a test to determine the next head and when the twins took it as children, Shizumasa cheated out of fear of what would happen if he lost the test and ended up winning. However as a result Takanari was badly injured and Shizumasa would regret his actions from that point on). When Takanari learns this he gives up on his grudge against his brother and goes to the hospital to give Shizumasa the transplant he needs.
* Takuto Kira from ''Manga/FullMoon'' is revealed to be a former ill boy. Like Mitsuki he had a cancerous tumor in his throat which lead to the end of his career as a singer. Also like Mitsuki he refused the operation that would save his life on the grounds that it would render him mute. In the manga he was given the operation anyway and the loss of his voice lead him to commit suicide [[spoiler: The final volume of the manga reveals that he survived and he had been in a coma ever since.]] In the anime he drove his motor cycle off a cliff shortly after being diagnosed. [[spoiler: He ends up back from the dead in both versions.]]

* ''Manga/FushigiYuugiGenbuKaiden'':
** [[spoiler:Uruki's father Temudan]] had always been sickly, and by the time the series begins his illness was so bad that [[spoiler: his limbs were replaced with prosthetics]]
** [[spoiler:Temudan's subordinate Urumiya Hagas]] isafflicted with a similar illness that is about to kill him. [[spoiler: He falls in love with Temudan's niece Firuka because [[FlorenceNightingaleEffect she took]] [[BecauseYouWereNiceToMe care of him]], and he ultimately brews a SelfSacrificeScheme to both die '''and''' give the powers of the Urumiya Senshi to his twin younger brother, Tegu.]]
* ''Manga/BungoStrayDogs'': [[HistoricalInJoke Akutagawa Ryunosuke]] is very underweight, has a sickly appearance and frequently coughs, and a [[AlternateUniverse special spinoff]] even has him introduced as the “Prince of the School's Hospital Wing”. It's likely a ShoutOut to the author he is named after, who was psychically (and mentally) unfit for most of his life.
* In the original ''Literature/TheSecretGarden'', Colin Craven isn't ill per se but is weak and gets sick a lot from spending all his time shut up in his room, never leaving his bed and having hysterical tantrums. In the AnimatedAdaptation, ''Himitsu no hanazono'', Colin still throws tantrums and holes up in his room, but ''is'' genuinely sickly. [[spoiler: And he is at least once in the verge of death.]]

* ''Anime/GargantiaOnTheVerdurousPlanet'' has [[WiseBeyondHisYears Bebel]], younger brother to [[TheHeart Amy]]. He has some sort of lung problem that keeps him mostly bedridden, and otherwise he's usually in a wheelchair to keep from overexerting himself. Part of [[AntiHero Ledo]]'s character growth comes from realizing that back in the Galactic Federation, Bebel would have been summarily euthanized [[spoiler:like Ledo's own brother]].
* ''Manga/InnocentsShounenJuujigun'' subverts this with Etienne's companion Remy, who has the kind and gentle personality to a T... but his illness is Hansen's disease aka ''[[https://en.wikipedia.org/wiki/Leprosy leprosy]]'', which has BodyHorror-like consequences on him and forces him to cover his body with bandages. He joins the Children's Crusades in hopes of finding a cure, but his health keeps getting worse... [[spoiler: By the time he dies his body is '''literally''' falling apart, as seen in how his nose is missing and his face has rotten away.]]
* Shigeo "Mob" Kageyama of ''Manga/MobPsycho100'' has chronic anemia and frequently passes out from overexhertion despite his dilligent committment to the Body Improvement Club. While this is normally played for laughs, it also proves to be a DramaPreservingHandicap when [[spoiler:Toichiro initiates his plan to take over Seasoning City just after Salt Middle School's annual 5 km marathon and Mob, already exhausted and [[GameBreakingInjury injured]] from the run, passes out early into Claw's assault.]]

* In ''Literature/TheTwelveKingdoms'', the holy beasts named ''kirin'' choose [[FisherKing each of the rulers]] for the realms. If said king or queen doesn't do well and the land suffers, they get struck with a fatal illness named ''shitsudou'', manifesting itself via FacialMarkings and physical weakness that quickly kills them. Only the full redemption (which has never happened) or the RedemptionEqualsDeath ([[spoiler: Joukaku of Kei and Shishou of Sai]]) of the sovereign can save them from death. Kirins of ''both'' genders (Hourin, Kourin and Sairin are females; Keiki is male) have gotten it due to their masters's mistakes or madnesses: [[spoiler:Sairin and Keiki]] get better, [[spoiler: Hourin and Kourin]] do not.
* In ''Manga/{{Gangsta}}'' the entire Twilight ''race'' is essentially compromised of Ill Boys and Ill Girls. All of them are born addicted to a PsychoSerum that they must take daily to prevent the withdrawal symptoms - only for the drug to eventually accumulate in their systems, breaking down their bodies and killing them. The whole reason they're called Twilights is because the this effect makes it a damn miracle if any of them live to hit thirty.

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* Hikari (Kari) Yagami in ''Anime/DigimonAdventure'', younger sister of Taichi (Tai), who gets the IncurableCoughOfDeath during one episode. It's later stated that Hikari had not properly healed from a huge cold that left her bedridden and unable to join the kids who'd become the Digidestined in their fateful school trip. Said cold came back with a vengeance when they were in the Digital World, causing Hikari to fall down with a fever that was just as bad as back home -- only that in this particular SickEpisode, they had no ways to properly treat her, and for worse Machinedramon was tracking them. It triggered Taichi's bad memories of the incident in which, years ago, he accidentally caused Hikari to almost die of pneumonia.
** Relena Norstein from ''Anime/DigimonDataSquad'', which led to her older half-brother Touma joining sides with [[SmugSnake Kurata]] to get her "cured." This is a prime example of the writers not defining the disease: she's in a wheelchair, although she can walk short distances, and [[spoiler:[[DistantFinale Touma wins the Nobel Prize for curing her]],]] but it's incredibly vague otherwise.
* Chiho, Uzume's Ashikabi from ''Manga/{{Sekirei}}'' has a mysterious unnamed illness that keeps her hospitalized. It later becomes a pivotal plot point towards the middle of the second season (Pure Engagement)
* ''Manga/FruitsBasket'':
** Rin (stomach ulcers [[spoiler: coming from her BrokenBird personality and the stress of her [[AbusiveParents horrible former home life]] ]]) and [[spoiler: Akito (unclear illness; maybe the same sickness that killed her father, or maybe psychosomatic)]]. Even though they're sick, they both scare the living crap out of people: Rin because she's headstrong and harsh, [[spoiler: Akito because she's the feared leader of the Sohma clan.]]
* ''Manga/RurouniKenshin'': Sayo Mutou aka Magdaria, the younger sister and MoralityPet of Shougo Amakusa, has an IncurableCoughOfDeath (and some BloodFromTheMouth). Unlike other cases, though, we know what she has: it's tuberculosis, Magdaria's had since she was a little girl, and she even "inherited" it from her MissingMom, also an Ill Girl. [[spoiler:That's not what kills the poor girl, though. She [[TakingTheBullet takes the bullet]] for a person who's willing to help her brother and his followers and dies in Sanosuke's arms. Even if she didn't, [[DiabolusExMachina Sayo was almost in the terminal stage so she would've died anyway]].]]
%%%* Marie in ''LightNovel/SisterPrincess''.
* An episode of ''Anime/GalaxyAngel'' has an ill Mint in a hospital while watching the leaves on a tree -- she hopes to live long enough to watch a leaf fall off -- and it promptly does, at which point she notes she was referring to ''another'' leaf, which also falls off. As she tries to refer to a ''third'' leaf, ''all'' the leaves are blown off by a strong wind. Another character, Chitose, is an obvious parody, claiming to have been confined to a hospital most of her life. More likely it's another product of her attention whoring; she was enough of a [[TheScrappy Scrappy]] in [[VideoGame/GalaxyAngel the game]] that even the anime writers didn't like her, and her personality was exaggerated to that of a {{wangst}}y histrionic (although to be fair, everyone else was exaggerated too).
* Hayate Yagami in ''Anime/MagicalGirlLyricalNanohaAs''. [[spoiler:However, in the sequel series ''[=StrikerS=]'', she is completely healthy. This because her "illness" was actually the curse of the Book of Darkness, so once the Book was destroyed she was able to recover.]]
* Hyatt in ''Manga/ExcelSaga'' is a particularly over-the-top parody of this, as she tries to go about her duties as an agent of [=ACROSS=] despite her tendencies to [[DeathByFallingOver collapse]], cough up contaminated blood (which kills small birds and sickens humans), faint, or even drop dead and then spontaneously come back to life. She ''always'' comes back to life, once even being charred to a decent crisp only to sit up later, as if nothing had happened. This appears to be an empathetic illness, at least in the manga. For several volumes Hyatt went some time without her usual blood and death routine, but the revelation that the competent Excel was an impostor brought it back.
%%%* Rika in ''Manga/HanbunNoTsukiGaNoboruSora''.
%%%* Kaori in ''LightNovel/StrawberryPanic''.
%%%* Akiko from ''Manga/ItazuraNaKiss''.
* ''Franchise/SailorMoon'':
** ''[[Anime/SailorMoon Sailor Moon R]]'': {{Anti Villain}}ess An occasionally fell into the archetype, getting tired and out of breath easier than [[BrotherSisterIncest her "brother/lover"]] Ali/Seijuuro. Although in An's case this was caused by her starving, since she refused to eat regular food like Ali did, and humans' life energy wasn't available every time she needed it.
** Hotaru Tomoe, who suffers seizures and cannot make huge physical efforts. She more than once ends up collapsing in the streets.
** One-time character Misa-chan from the Stars season, an hospitalized little girl who bonds with Taiki/Sailor Star Maker.
* Megumi aka Megu, Suigintou's medium and MoralityPet from ''Manga/RozenMaiden''. She has extremely low self-esteem as a result, and Suigintou sorta empathizes with her.
* Shizuka Kawai (a.k.a. Serenity Wheeler) from ''Franchise/YuGiOh'' prior to her operation. (In the [[Anime/YuGiOhFirstAnimeSeries first anime series]], she has an unspecified disease, but in the [[Manga/YuGiOh manga]] and [[Anime/YuGiOh second anime series]], she's going blind.)
** It turns out that [[spoiler: Pegasus]]'s FreudianExcuse was centered around one of these: [[spoiler: his deceased fiancée and VictoriousChildhoodFriend Cecilia, who died of illness few before their wedding.]]
* Veronica from ''Manga/{{Gangsta}}'', the mysterious Twilight woman that once resided at Benriya with protagonists Nicolas and Worick. It appears she overdosed on the Cereber drug and became terminally ill, at one point while visiting a brothel Alex sees (through a partly closed door) Nic possibly tending to Veronica on her sickbed. Whoever she is or whether she’s still alive, Nic appears to have had a close relationship with Veronica and flashes back to her sometimes when interacting with his new LoveInterest Alex.

* ''Anime/CodeGeass'': Nunnally Lamperouge/vi Britannia, the younger sister of the main character, is both blind and contained in a wheelchair after she witnessed and barely survived their mother's brutal murder. He promises her that by the time she gets well, the world will be a better place. He never mentions ''how'' -- to him, [[WellIntentionedExtremist it doesn't matter how many people have to die or be manipulated]] to destroy the TheEmpire. Further, [[spoiler:she didn't actually see it, having been a false witness due to a memory-altering Geass. Also, she gets better with time: in the series, she stays in a wheelchair but regains her sight ''and'' becomes the Empress of Britannia, and in the ''[[Manga/CodeGeassNightmareOfNunnally Nightmare of Nunnally]]'' manga she heals completely and stays under the wing of Empress Euphemia Li Britannia.]]
** Also, fellow student and revolutionary Kallen Stadtfeld/Kozuki uses the ''image'' of the Ill Girl to cover up her frequent absences from school so she can go play revolutionary. Maintaining the illusion limits her somewhat, but fortunately there's usually a distraction around to keep others from asking when she makes an unexpected display of physical prowess. Lampshaded in the 2nd picture drama, where Shirley [[SkinshipGrope grabs a naked Kallen from behind]] while they're bathing and comments on how Kallen is ''much'' stronger and athletic than she's supposed to be.
* Subversion, possible parody: Kagome's never-ending parade of fake illnesses in ''Manga/InuYasha'' [[HilarityEnsues causes much sympathy and embarrassment.]]
** Kikyou took this role more than once, despite being undead. Namely, it happened every time she was either weakened by poison or suffering the physical downsides of her clay body.
* Though it's never mentioned in the anime, Kurz Weber of ''LightNovel/FullMetalPanic'' is stated to have joined Mithril in order to pay the hospital bills of a young girl who was critically injured in a mission he was involved in. [[spoiler:More exactly, during the assassination of the man responsible for the deaths of Kurz's parents. Kurz, who was supposed to take the shot, stopped when he realized that the poor girl would also be hit; his ColdSniper mentor, Wilhelm Casper, had fewer scruples and fired anyhow]].
* ''Manga/MermaidMelodyPichiPichiPitch'' has Michal Amagi, a Tomoe Hotaru-esque figure that also happens to be Lucia's [[ClingyJealousGirl romantic rival]] and the little sister of one of the villains. [[spoiler: It's a wonder she survives, really.]]
* Anju Kitahara in the anime version of ''Manga/MarmaladeBoy''. She has [[HeartTrauma a weak heart]] and might not live for long if she doesn't go through a ''very'' dangerous operation in the USA, but [[PluckyGirl she attempts to remain cheerful]] and befriends her beloved Yuu's girlfriend Miki, telling her [[IWantMyBelovedToBeHappy that she won't break them up]] and is as happy as she can with being Yuu's UnluckyChildhoodFriend. [[spoiler:She's operated and gets better, and when Yuu breaks up with Miki she has a small chance to get Yuu for herself, but ultimately she (and Miki's other love interest Kei) give up when they get back together.]]
* Toji Suzuhara's off camera sister in ''Anime/NeonGenesisEvangelion'': After the injuries she suffers among the civilians caught in the middle of the fight in the first two episodes, Toji is eventually recruited as the pilot of Unit 03 in exchange for her being transferred to NERV's medical facilities. However, [[spoiler:Toji himself is severely crippled when an Angel takes over his Eva.]]
** In ''Anime/{{Rebuild|OfEvangelion}}'', we get to see Toji doting on his little sister as she finally gets out of the hospital, [[spoiler: and Asuka ends up piloting Unit 03 in his place.]]
* In ''Anime/FafnerInTheAzureDeadAggressor'' Shouko Kazama is the ultimate Ill Girl who suffers from some incapacitating disease that makes her a recluse of sorts. The trope is subverted though since [[spoiler:her death is not caused by her illness, instead Shouko sacrifices herself for the sake of the island in a grand HeroicSacrifice]].
* Otohime Mutsumi from ''Manga/LoveHina'', who has a severe case of anemia and passes out almost everywhere. During her CrashIntoHello with Keitaro, she fell over, with BlankWhiteEyes ''and'' BloodFromTheMouth. Keitaro checks for a pulse...and there isn't one. Cue FreakOut. She got better, but it seems her fainting spells are closer to actually dying then "normal" fainting.
** Naru ''used'' to be an Ill Girl as a child. She has asthma, and while she's mostly fine in teenage/adult years, in her childhood her attacks were much more serious. [[spoiler: Several years ago, Naru's parents sent her to Hinata Sou hoping that she'd recover due to the zone's benign climate, but she was very lonely and depressed. That was the time when she befriended two older kids, Keitarou and Mutsumi, and the three made ThePromise.]]
* Fujimiya Aya fills this role for most of ''Anime/WeissKreuz'' after she's hit by a car and ends up comatose, prompting her older brother Ran to become an assassin to pay her hospital bills--and to actually assume her name in tribute. [[spoiler:She ultimately gets better.]]
** In one episode Ran encounters another Ill Girl, whose brother has entered a DeadlyGame to pay her medical bills.
* Mitsuki Koyama from ''Manga/FullMoon'' has a [[LittlestCancerPatient cancerous tumor]] that prevents her from singing, and gives her exactly one year left to live. When she transforms into "Full Moon", she temporarily loses this tumor, and gains an amazing singing voice.
** Notably Mitsuki's mother and grandmother were both ill girls in the manga. Fuzuki(the grandmother)was shown to be very sickly in her youth though she apparently to grew out of it. Hazuki(the mother) is implied to be an ill girl in a flashback when it is stated by Fuzuki that she isn't healthy enough to have a baby after Hazuki announces her pregnancy.

%%* Himeka Karasuma from ''Manga/KamichamaKarin''.
%%* Hisami Hisaishi from the ''[[Anime/ReadOrDie Read Or Dream]]'' manga and ''Anime/RODTheTV''.
* ''Manga/GunslingerGirl'': ''All'' the girls will meet the same fate, since their lifespan is immensely shortened due to their cybernetic implants and the side effects of the conditioning drugs they have to take. More specifically:
** [[spoiler:Rico]] turns out to have been an Ill Girl prior to becoming a cyborg, languishing away in an hospital after [[ParentalNeglect her parents simply abandon her there to her luck]] until she's taken in by the organization.
** [[spoiler:Angelica]] is the first of the girls to be graphically shown breaking down due to conditioning sickness.
** [[spoiler:Claes]] stops taking roles in missions not just because of [[spoiler:her trainer Raballo's death]], but because she actually has a weak heart.
** [[spoiler:Elisabeta]], a Chernobyl survivor and former aspirant ballerina who developed cancer [[spoiler:and tried to commit suicide after her cancerous leg was amputated. Then she was brought into the Agency and became Petrushka aka Petra]]. At the end of the manga, [[spoiler:her cancer returns in the form of leukemia, but she dies peacefully, unlike many of the other girls]].
* Parodied in ''Anime/MagicalProjectS'', where one of the [[MonsterOfTheWeek Love-love Monsters]] is called "fake sick girl", who even gives the speech about not seeing the last leaf fall from a tree. When the person talking with her mentions that the tree is quite full and healthy, she blows it up with a cannon hidden in her bed.
* Chopin in ''Manga/Classi9'' is a male example. He is sick so often Liszt knows exactly what to do when someone else gets sick and the cast uses his personal pharmacy when Ren gets a cold. His weak constitution isn't helped by his PerformanceAnxiety and he already passed out on stage before chapter 7, which takes a toll on his health. TruthInTelevision as the real life Chopin's cause of death is still debatable because ther are doubts on which illness finally killed him, he was also sick a major part of his life and did prefer small and cozy venues to big concerts.
* Subverted quite quickly in ''Manga/TheDaughterOfTwentyFaces'', in that the "ill girl" is in fact the main character who recovers quite quickly when taken away from the source of her "illness" by the eponymous GentlemanThief Twenty-Faces.
* ''Manga/OnePiece'', quite a few actually, mothers especially bite it:
** Usopp's best friend Kaya from is very delicate young woman who goes through quite the BreakTheCutie. She got better later, though.
** The same can not be said for Bachina, Usopp's mother who died of her own illnesses despite her son's best efforts to cheer her up. This likely made Usopp strive to get Kaya better.
** Nami falls ill after [[EverythingsBetterWithDinosaurs Little Garden]], when she's bitten by a prehistoric bug. As a consequence, she gets a dangerously high fever and [[SickEpisode the journey to Alabasta must be put on hold as they find a doctor]]. Though that meant Luffy and Sanji must take her up a freezing cold DeathMountain, Nami is cured just in time: according to Dr. Kureha and Chopper, three days later she'd be dead.
** Rocinante and Doflamingo's mother had a bad health, which got even worse after the patriarch of the Doquixote family [[DefectorFromDecadence left the World Nobles to live among the populace]] [[RichesToRags and they lost everything]]. She ultimately died of her illness, [[EvenBadMenLoveTheirMamas which Doflamingo]] blamed on their father and, among other things, led him [[SelfMadeOrphan to kill]] [[PatriCide him]].
** [[AntiVillain Senor Pink's]] wife Russian became a catatonic EmptyShell after a brutal BreakTheCutie process that included [[OutlivingOnesOffspring the death of their baby son Gimlet]], her finding out her husband wasn't a traveling businessman but a pirate (aka the type of people she despised the most), ''and'' suffering brain damage after being caught in a landslide. She could only smile when Pink dressed up like a baby, and in the present she's strongly implied to have died of a broken heart and her bad health.
** [[spoiler: Vinsmoke Sora, Sanji's mother, ''made herself sick'' as a side-effect of a risky gambit she took. As her husband [[ArchnemesisDad Judge]] genetically modified her quadruplet sons while they were in her womb, so that they'd be souless [[ChildSoldiers killing machines]], Sora desperately tried to counter this and took a drug to nulify the changes; as a side-effect her health took a nosedive from then on, but she was overjoyed to see that Sanji had turned out [[WhiteSheep decent]] (though his brothers couldn't be saved), and doted on him and his sister Reiju before passing away.]]

* ''Anime/LuckyStar'':
** Kanata, Konata's mom and Soujiro's wife, apparently died in a very Ill Girl way early. That, and the couple being {{childhood friend}}s, Kanata being [[OlderThanTheyLook older than she looked]], made [[GenreSavvy Konata]] wonder if the whole thing is a DatingSim plot. Kanata's [[OlderThanTheyLook super youthful looks]] ''are'' related to the disease, so [[OlderThanTheyLook Konata]] ''may'' fall victim to the same disease... (At least one rather absurd DarkFic {{Doujinshi}} had her develop into a suicidally depressed college student living in fear of her possible demise.)
** [[CheerfulChild Yutaka]], Konata's ''paternal'' cousin, has recurring (albeit mild) health problems that make it difficult for her to keep up with her friends-- she was nearly rendered a BrokenBird from the social isolation caused. And her case of OlderThanTheyLook is even more severe than Kanata's...
%%* ''Anime/ParanoiaAgent'' actually features a direct parody of "The Last Leaf".
* Parodied and played melodramatically in ''LightNovel/VenusToMamoru''. During the Valentine's Day episode, a contest is on to see who can give Mamoru chocolate in the most creative way possible. Shione orchestrates a "Last Leaf" situation with her brother claiming her lack of fashion sense is a disease affecting "one in six billion people" that will kill her. In the end, Shione "dies", but not before giving Mamoru her chocolate...[[AnimeHair shaped like her hairstyle]].
* [[spoiler: Yuuki Konno]] from ''LightNovel/SwordArtOnline''. [[spoiler:She contracted AIDS when she was born. By the time she was introduced in ''Mother's Rosario'', she was already blind, bedridden and on the verge of death in the real world.]]
* [[spoiler:Sora]] from ''Manga/SomedaysDreamersIISora'' seems to be mostly in good health, having little trouble with physical exercise or performing straining magical rituals--until she suddenly appears to have been suffering from a terminal heart condition for a while already, leading to a severe {{mood whiplash}} in the series.
* There are several in the ''Franchise/{{Gundam}}'' meta-series.
** Four Murasame from ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]''. As a side effect of [[TykeBomb the experiments and treatments she's been subjected to]], she sometimes suffers extremely serious migraines; when that happens, the poor girl ends up almost unvariably on the ground/floor, either whimpering or screaming in utter pain, and needs medicines to get rid of it.
** Played with in ''[[Anime/AfterWarGundamX Gundam X]]''. Female lead Tiffa Addil is a FaintingSeer and kinda delicate, but this doesn't stunt her that much. Her ''only'' brush with death was actually [[spoiler: a side-effect of her being ''poisoned'' by one of the villains.]]
** Stella Loussier from ''[[Anime/MobileSuitGundamSEEDDestiny Gundam SEED Destiny]]''. Being [[TykeBomb one of the Extended]], her life hangs on by treatment in the Alliance medical rooms and she ''will'' die if she doesn't get it, which is shown in her seizures and memory gaps. For worse, the training has damaged her mind as well, and she's few more than a [[PsychopathicManchild very childish]] [[TheOphelia Ophelia]] almost unable to function in real life when outside missions. [[TheWoobie Yeah, it sucks to be her.]]
** ''[[Anime/MobileSuitGundam00 Gundam 00]]'': [[spoiler: Louise Halevy]] in the second season. [[spoiler: To start, Louise lost her left hand in the bombing incident that decimated her family in the first season. She got said hand back through an undisclosed medical treatment and TookALevelInBadass that led her to become a DarkActionGirl, but she also had some very ugly seizures and had to pop some pills. Her sanity continued slipping as the series advanced, but luckily, by the end she starts getting better. In TheMovie, she's mentally doing better but still in physical recovery.]]
** Lu Anon from ''[[Anime/MobileSuitGundamAge Gundam AGE]]'' is a tragic non-combatant example. A Vagan girl who is Kio Asuno's age, she suffers from a terminal disease due to exposure to Mars Rays. In the little time she has left, she wants to live happily and normally, [[spoiler:especially after she meets Kio. The time they spent together and her heartbreaking death became major turning points in Kio's attitude towards the enemy and the war.]]
*** Similarly, [[spoiler: Kio's CoolBigSis Shanalua Mullen]] has a little sister who's ill and needs an expensive treatment. [[spoiler: And then it turns out that Shanalua became TheMole to [[HealthcareMotivation pay said sister's hospital bills]].]]
* Subverted in ''Manga/IkkiTousen'': [[spoiler:Ryoufou Housen]] is dying of an undisclosed illness, but she's still a fearsome DarkActionGirl [[spoiler:and actually goes down fighting. In the anime, she [[DeathIsCheap gets]] [[BackFromTheDead better later]], though that also included some LaserGuidedAmnesia... ''and dying again'' in the end.]]
* Someone subverted in ''Manga/{{Planetes}}'', where during a hospital stay Hachimaki meets a girl who he believes to be chronically ill, but does not want to be rude by asking. In reality, she is a child who was born on the moon, and is staying in the hospital to provide medical information to scientists and doctors.
* ''Manga/NegimaMagisterNegiMagi'' has [[TheWoobie Ako Izumi]] briefly filling the role after she catches some sort of disease upon arriving in Magicus Mundus. It varies a little bit in that she gets the cure early on, but it's so expensive that it forces her and two of her friends (Natsumi Murakami and Akira Ookochi) to sell themselves into slavery. This in turn leads to Negi having to enter a tournament to win the money to buy their freedom.
* In the ''Anime/CowboyBebop'' episode "Waltz for Venus," Spike befriends a smuggler named Roco who is trying to earn enough money to pay for his blind sister Stella's eye operation. [[TearJerker It ends in tragedy.]]
* Kotori Monou from ''Manga/{{X 1999}}'' has a serious heart condition. One of her older brother Fuuma's first scenes in the manga has him reading out loud a list with the remedies that Kotori has to take that day.
** Subverted with Hinoto. She's deaf, mute and blind... but that's due to being BlessedWithSuck via possessing ''massive'' PsychicPowers [[SuperpowerLottery of several kinds]] that overwhelm her body.
* ''Manga/JoJosBizarreAdventure'': Jotaro's mother Holly, if "PowerIncontinence activated by the BigBad's resurgence" counts as an disease.
* Chiyuki from ''Manga/MillenniumSnow'' has a heart condition and isn't expected to live for too long. Then, she becomes the blood source of the local vampire Tooya, which extends her lifespan to match his own.
* {{Deconstructed}} in a ''Manga/CaseClosed'' case: Our Villain of the Week had a bad heart, but it was she who killed the loanshark who [[DrivenToSuicide drove her boyfriend to suicide]] over the money for "that operation" (see FingerLickingPoison for the murder itself). God, is she a bitchy ''chain smoker''. In her confession, she mentions that her boyfriend was her MoralityPet and the only one who ever loved her after her parents's deaths. Be careful when threatening an Ill Girl's loved ones: if she gets better, she'll kill you!

* Subverted quite cruelly with Aiko from the ''Manga/VampirePrincessMiyu'' OAV, who was thought to be in a ConvenientComa due to either illness or DemonicPossession, but Himiko later discovered that [[spoiler: she summoned the main Shinma in despair after blaming herself for her parents's death, having survived the accident that caused their demises. Ever since then, she lays on her old futon located in her her decadent BigFancyHouse and simply... sleeps, while the Shinma wreaks havoc around. She only wakes up when Himiko confronts the Shinma, but Miyu stops her when she's about to drink Himiko's blood, and once the Shinma is defeated Aiko dies.]]
* In the ''Miyu'' SpinOff series of sorts ''Vampire Princess Yui'', this is also subverted. It's believed that Yui is an Ill Girl with severe anemia, but the truth is that her Guardian powers have just awakened and, since she had no real idea of what was going on, she lacked of the blood "meals" she needed. (It's not helped by how Yui at first refuses to drink blood from humans if she can help it, so her BattleButler Nagi gives her his blood instead.)
* Though no one takes her seriously, Mokuzu Umino of ''Manga/SatouKashiNoDanganWaUchinukenai'' claims that her painful limp and clumsiness were caused by a witches spell that turned her into a human with an imperfect pair of legs. She says this same spell will turn her into sea foam in one months time if she does not fulfill her wish of finding a "precious friend." She also must drink copious amounts of water before speaking or exerting herself in any way. [[spoiler: It turns out Mokuzu's been abused by her father Masachika for years: her limp is due to a hip injury received as a baby, and to top if off she is deaf in one ear due to her dad's beatings as well. And even worse, she is later ''[[OffingTheOffspring beaten to death]]'' by him.]]
* ''Very'' cruel version: [[spoiler:Miyuki Aiba/Shana Carter aka Tekkaman Rapier/Teknoman Shana]] from ''Anime/TekkamanBlade''. [[spoiler:She's actually a Tekkaman whose transformation process was incomplete, therefore she suffered horrible pains and her lifespan was dramatically shortened... therefore, she chose to go down fighting and perform an HeroicSacrifice than die of her illness.]]

* ''Manga/{{Bleach}}'': A girl named Hisana was forced to find a way to survive in one of the worst districts of the Rukongai, so abandoned her baby sister Rukia to do it. Marrying Byakuya gave her the opportunity to search relentlessly for any sign of Rukia's fate, as she could never forgive herself for leaving her, but it's implied to have driven her to the sickness that ultimately claimed her life. Her dying breath was used to beg Byakuya to keep searching for her and adopt Rukia as his own if he ever found her.
* Inori's older sister Seri in ''VideoGame/HarukanaruTokiNoNakaDe''; Inori even has the BigBrotherInstinct towards her because of this, despite him actually being younger. A flashback in the ''Hachiyou Shou'' TV anime reveals that this is part of the reason Seri got close with Iktidar, who saved her when she was threatened by several men while helpless from her condition. [[spoiler:Somehow, being an Ill Girl didn't stop Seri from having Ikutidaru's baby.]]
* Subverted with Izumi Curtis from ''Manga/FullMetalAlchemist'': a [[EeriePaleSkinnedBrunette pale]], slender, [[SexyMentor attractive]] IronWoobie with frequent attacks of BloodFromTheMouth [[spoiler: as a result of having tried human transmutation to bring back her stillborn child, and losing her inner organs to The Truth as a result.]]. It's sometimes PlayedForLaughs when she coughs up blood on someone who upsets her, she can kick that someone's ass, {{bears|AreBadNews}}' asses, and her [[HugeGuyTinyGirl gigantic]] [[BigBeautifulMan husband]]'s ass, and it generally need not be said that no one [[DontYouDarePityMe should just pity her]], because she's so fierce. Also, [[spoiler: she gets better... though only in the manga and the ''Brotherhood'' series, as in the first anime she passes away in between the events of the GrandFinale and TheMovie.]]

* Kozue Ayuhara from the old-school anime ''Manga/AttackNumberOne'' is ill and has to quit sports awhile and move where she can rest because of it, until she comes back and joins the volleyball team.
* Kosumo Koganehara from Creator/MichiyoAkaishi's ''Manga/TowaKamoShirenai'' was born with a [[HeartTrauma a weak heart]], and in fact the manga starts when she has a seizure during her treatment in the USA and needs an urgent transplant, but her extremely rare blood type doesn't allow for an easy one. The donor that saves her life just ''happens'' to be Himiko, a {{Miko}} and MagicalGirlWarrior who has just died via an HeroicSacrifice to save a child, so Kosumo inherits her powers alongside her heart and blood and must take up her demon slaying mission - with the help of Himiko's TallDarkAndHandsome guardian, Hitsuji.
** And later there is another: [[spoiler: the 98th Himiko, the one who came before the aforementioned Himiko we know. She was a fellow {{Miko}} who died of cancer when the 99th Himiko was 10 years old, which wasn't helped by her already suffering of a years-long depression and being separated from her bodyguard and lover Hishou.]]
* ''Manga/Reborn2004'': Chrome Dokuro/Nagi will die if Mukuro [[spoiler: or Daemon Spade]] isn't giving her illusionary organs to replace the ones that she lost when she was hit by a car.
* ''Manga/YourLieInApril'':
** Kousei's mom, Saki, already passed away from illness before the series began. Even more unfortunately, [[spoiler: Saki's emotional state upon being diagnosed became so bad, she turned into a mix of AbusiveParent and EducationMama to Kousei, pressuring him beyond his limits in an horribly misguided attempt to make him both perfect ''and'' self-reliant.]]
** Kaori Miyazono is one as well. It's first hinted in episode 4 (when she collapses after her performance) and further shown in episode 9, when a lot of pills can be seen in her bag. [[spoiler:Then in episode 15, her legs give out in the middle of the hospital hallway at night. And in episode 16, her arms can't hold up her bow or, at the very least, a bottle of juice Kousei hands her]]. While her disease is unnamed, it's explained that she will lose control of her legs and her limbs and suffer from seizures that will lead to heart failure; most fans have suspected that due to the symptoms, she [[spoiler: and probably Saki too]] suffered from [[http://www.alsa.org/ Amyotrophic Lateral Sclerosis aka ALS.]] [[spoiler: And Kaori dies from the illness too.]]
* [[spoiler: Tamaki's French MissingMom, Anne-Sophie Grantaine]] in ''Manga/OuranHighSchoolHostClub''. More exactly, [[spoiler: she has lupus]].

* [[spoiler: Homura Akemi]] from ''Anime/PuellaMagiMadokaMagica'', before meeting Madoka and her friends, was this. She spent most of her life in the local hospital due to [[HeartTrauma a severe heart illness.]] It's not specified how she got rid of it, but most likely did it with [[spoiler:her MagicalGirl powers]]. This is also the basis of her attitude towards [[spoiler:Madoka]], as her social isolation and orphanhood means the latter is the first and {{only friend}} she could made for the past ''14 years''.
** Also, according to popular {{Fanon}}, [[spoiler:Nagisa Momoe, who became Charlotte the Dessert Witch, may have been one when she was still a MagicalGirl]]. What prompted this EpilepticTree was [[spoiler:that her Grief Seed first appeared outside a hospital, there is a general medical theme to her barrier as well as the sweets, and the fact that she's obsessed with cheese, which chemotherapy patients aren't allowed to have]]. Add in the detail that Kyubey ''has'' contracted girls on the verge of death at least once (see: [[spoiler:Mami, who had been seriously injured in the car crash where her parents died]]), and this theory became popular.
*** According to WordOfGod, [[spoiler:Nagisa's mother turned out to be this, as she was dying, and Nagisa's wish was to share a cheesecake with her mother before she died. Whether or not Nagisa was also ill has not been specified]].
* Yuki Miyata from ''Literature/{{Moshidora}}''. Her illness is not specified, aside of being a congenital one; her hospitalization requires her best friend Minami to take her place as the local CuteSportsClubManager. [[spoiler: Unfortunately, Yuki does NOT get better, and Minami suffers an HeroicBSOD when she dies.]]
* Anju Marker from ''Manga/{{Karin}}'' is ''believed'' to be this. [[OurVampiresAreDifferent That's far from the truth, obviously.]]

* Haruna from ''[[Anime/TenchiMuyo Tenchi Forever!]]'' is this. After fleeing with her lover, [[spoiler:Yosho/Katsuhiko]], she became ill during their trip. [[spoiler:She died]] before the couple arrived on Earth.
* [[spoiler: Ultear Milkovich]] from ''Manga/FairyTail'' was this in the past. [[spoiler: Then she fell in the hands of a bunch of {{Mad Scientist}}s whom her mother asked for help, not knowing about their intentions; they ''did'' heal the little girl, but they told Ur that she had died and ''then'' told their ex-patient that her mother had abandoned her... just so they could make the desperate Ultear their DarkActionGirl TykeBomb.]]
** [[spoiler: Layla Heartfilia]] had been born with frail health and it contributed to her death when she had to use her own life energy to open the [[spoiler:Eclipse Gate]].
* Kaoru "Kaoru-no-Kimi" Orihara from ''Manga/DearBrother'' was held back a year due to an unspecified illness, and when the story begins she has just returned to Seiran Highschool. As such, she not only [[BerserkButton hates it when people neglect their physical well-being]], but sometimes collapses in fits of pain and needs both rest and painkillers. [[spoiler:What's her ailment? ''Breast cancer'', and she even had to go through a ''mastectomy'' at age 16, which caused her to break up with her then-boyfriend Takehiko (the titular Oniisama), and when she returned, she kept her illness a secret from most of her classmates until the symptoms of a possible relapse were shown towards the end.]] What happens to her varies according to the different continuities: [[spoiler:In both of them she goes to Germany with Takehiko after they rekindle their relationship... but while she lives on and they stay HappilyMarried [[BabiesEverAfter with a child]] in the anime, in the manga Kaoru ''does'' die two years after leaving Japan.]]
* Three show up in ''Manga/HonooNoAlpenRose'': Clara (temporary but plot-important illness [[spoiler: that has her brother rat out Jeudi and Lundi [[HealthcareMotivation to get enough money for her medicines]] ]]), Marie ([[spoiler: confined to a wheelchair, but starts to walk after befriending Lundi]], and specially [[spoiler: Jeudi's MissingMom Helene (weak heart and almost total blindness after the accident that separated her from Jeudi.)]]
** It's horribly subverted in the case of the third, too: [[spoiler: the villain Toulonchamp and his [[DaddysLittleVillain daughter]] Mathilda ''have been slowly poisoning her for years'' so they force her parents to collaborate in their schemes.]]

* Asa Shigure from ''VisualNovel/{{Shuffle}}'' suffers a mysterious illness that often leaves her bedridden, and starts becoming worse as time passes. [[spoiler: It's not an illness, but PowerIncontinence: her weak half-demon body cannot handle the strong magic inherited from her mother, the demon Ama, but Asa utterly refuses to use said power because Ama suffered ''horribly'' due to them, thus Asa doesn't want her mother to be sad. Rin has to [[TakeAThirdOption take a VERY risky third option]] to force her release said energy, and almost dies for it.]]

* Himari Takakura from ''Anime/{{Penguindrum}}''. Her illness isn't exactly clear, but it seems to be due to a weak heart. In fact, the plot is kickstarted when [[FirstEpisodeResurrection she dies and is revived in the first episode]]. [[spoiler: And it won't be the first time she kicks it.]]
* [[spoiler: Chizuru Nanbara]] from ''Anime/CombattlerV''. Her illness is explained [[spoiler: (malformed heart valve)]], it kicks in at a critical moment [[spoiler: ([[HeroicRROD during battle!]])]], and [[spoiler: while it keeps her away from action for a while, she's successfully operated on and returns to the battlefield.]]
* [[spoiler: Jintan Yadomi's MissingMom Touko]] in ''[[Anime/AnoHanaTheFlowerWeSawThatDay Ano Hana]]''. [[spoiler: Touko actually died a while before Menma did... and ThePromise that Menma made with her (making Jintan cry and show emotions) is Menma's forgotten [[GhostlyGoals Ghostly Goal]].]]
* [[spoiler:Countess Larissa Mikhailovna]] from ''Manga/HaikaraSanGaTooru'' has tuberculosis and because of that, [[YourDaysAreNumbered she has a very shortened lifespan]]. [[spoiler:In a subversion, she didn't die from the disease, but from a FallingChandelierOfDoom while making a DivingSave to save Shinobu.]]
* There were ''four'' in ''Anime/AngelBeats'' [[spoiler: when they were still alive: Masami Iwasawa (suffered a stroke after being hit on the head by her abusive father and died in the hospital), Yui (was quadriplegic after an accident and languished away in bed until she kicked it), Otonashi's dead little sister Hatsune (undisclosed illness that ultimately kills her) and Kanade "Angel" Tachibana ([[HeartTrauma heart illness]] that leads her to [[BillyNeedsAnOrgan need a transplant]])]]. In fact, [[spoiler: after the latter died, her main goal was to find and thank the person who donated their heart to her and allowed her to live a little longer... Said person turned out to be the male lead Otonashi.]]

* The title character of ''Binetsu Shoujo'' ([[LampshadeHanging "Feverish Girl"]]), Rina Kisaragi. She has anemia and tends to pass out quite a bit, so she often goes to a local hospital for check-ups.
* Toki Onjouji and Yuu Matsumi from ''Manga/SakiAchigaHen''. The former has a tendency to faint at any given moment, and the latter gets chilled very easily to the point where she has to wear a cardigan, mittens, and a muffler even ''during the summer''.
* Leonora Fenton in ''Anime/MyDaddyLongLegs'' seems to have classic symptoms of tuberculosis of the lungs. It's actually a heart condition [[spoiler: that gets corrected by surgery]].

* ''Anime/FutureGPXCyberFormula'':
** Lita is a girl who is in a wheelchair whom Hayato meets in the Peruvian GP. She recently has surgery for her legs, but she's afraid to use them despite them being completely healed. After the race, she gets up thanks to the courage he gives her.
** Elena is the daughter of the orangizer of the Fireball Race and has a weak heart since birth. During the race, she catches a fever while navigating with Hayato and as her fever worsens, he calls in HSR-III to take her to the hospital. She gets better at the end of the episode.
* TheMovie of ''Anime/HappinessChargePrettyCure'' has [[spoiler:a wheelchair-bound character, Tsumugi-chan, who was a ballet student before something happened that paralyzed her]].
* One of these, Madoka [[spoiler: Shibuya]], is rather important in the BackStory of ''Manga/{{Zetsuai 1989}}''. [[spoiler: Madoka was both a Kouji fangirl and the already fatally ill daughter of the president of Kouji's record company, and he had a PetTheDog moment by visiting her before she kicked it. Her older brother Katsumi decided to [[BecauseYouWereNiceToMe repay Kouji's kind action]] by becoming his manager.]]
* The third season of ''Anime/BakutenShootBeyblade'' has Monica, the younger sister of Moses. Her illness is never named but is quite serious as she needs a pricey operation badly. Moses became a blader at BEGA [[HealthcareMotivation specifically to help pay for it]].
* ''Anime/AldnoahZero'' has Lemrina, a teenage girl who must use a wheelchair to move around and is only able to walk ''very'' short distances when in a low gravity environment. [[spoiler: She's an illegitimate princess from Mars and, with some holographic disguises, she becomes the BodyDouble of her currently comatose older half-sister Asseylum, [[TheGloriousWarOfSisterlyRivalry whom she resents heavily]].]]
* In ''Manga/ChibiMarukochan'', Koharu-chan, the intelligent Nagayama-kun's little sister, in most episodes is sick either at home or in the hospital. Koharu-chan is worried that she might have to repeat a year of school and be left behind by her classmates. Nagayama-kun and his classmates try to cheer her up. Maruko-chan drew an animation for her to enjoy.

* In ''Manga/BlackButler'', Ciel's MissingMom Rachel Durless was asthmatic and passed her illness on [[IllBoy her son]]. Her sister Angelina aka the future "Madame Red" got the idea of becoming a doctor from her desire to help Rachel with her health problems.
* In ''Anime/ThreeThousandLeaguesInSearchOfMother'' (and the story that was its basis), one of the reasons why [[KidHero Marco Rossi]] is so desperate to find his mother Anna is that her last letter implies that her health's is decaying. Which means she might never come back home. [[spoiler: When Marco finally finds her, she's so ill and so depressed that she's rejecting one last operation that could save her life, despite the pleas of her doctor and her benevolent bosses. Seeing Marco again gives Anna the strength to go through the surgery, and she's saved.]]
* In ''LightNovel/AscendanceOfABookworm'', Maine is a peasant girl who looks younger than her actual age due to constantly getting sick. She has no stamina, little strength and is highly prone to fevers. As such she typically needs to get other people to do physical labor for her to actually make things and, even setting that aside, is subject to a mysterious fever that could easily kill her the moment she lets her guard down.
* Yuko Yoshida, the titular "Demon Girl" from ''Manga/TheDemonGirlNextDoor'' ''was'' one as a young girl, but her demonic awakening definitively took her ''out'' of this trope. Her experience with this trope, however, is an important to the universe's {{backstory}}.
## Ten years before PresentDay, she was ''deathly ill'' due to curses on the descendents of Myth/{{Lilith}}. Her mother Seiko recalls she was "struggling with the respirator" at one point. [[spoiler:Seiko implies it would have been fatal without [[BigGood Sakura]]'s intervention, and when Yuko makes contact with what's left of Sakura in her memories, she tells Yuko ''it was [[FateWorseThanDeath even worse than Seiko thought]]''.]]
## What [[spoiler:Sakura]] did was merely preventing her from ''dying'', but for a long time her health was bad enough that her first few years of education were ''in the hospital''.
## Her friend Anri mentions that before her demonic awakening, Yuko often had to leave school early or miss it entirely because she was in the hospital so much.
* Ruri from ''Manga/DrStone'' is introduced as having been sickly most of her life. [[spoiler:Senku manages to cure her.]]

* {{Deconstructed}} in a ''Manga/DetectiveConan'' case: Our Villain of the Week had a bad heart, but it was she who killed the loanshark who [[DrivenToSuicide drove her boyfriend to suicide]] over the money for "that operation" (see FingerLickingPoison for the murder itself). God, is she a bitchy ''chain smoker''. In her confession, she mentions that her boyfriend was her MoralityPet and the only one who ever loved her after her parents's deaths. Be careful when threatening an Ill Girl's loved ones: if she gets better, she'll kill you!

* ''Manga/DetectiveConan'' has several:

* Suzu's best friend Seishuu in ''LightNovel/TheTwelveKingdoms'' got a head injury as a little child, in the same incident with monsters that got his mother killed. As a consequence, he sustained brain damage and suffers constant headaches. [[spoiler: He later [[HeroicRROD goes blind as a side-effect]], which gets him killed when [[LookBothWays he cannot see a carriage going towards him and gets hit point-blank]].]]

* In ''LightNovel/TheTwelveKingdoms'', the holy beasts named ''kirin'' choose [[FisherKing each of the rulers]] for the realms. If said king or queen doesn't do well and the land suffers, they get struck with a fatal illness named ''shitsudou'', manifesting itself via FacialMarkings and physical weakness that quickly kills them. Only the full redemption (which has never happened) or the RedemptionEqualsDeath ([[spoiler: Joukaku of Kei and Shishou of Sai]]) of the sovereign can save them from death. Kirins of ''both'' genders (Hourin, Kourin and Sairin are females; Keiki is male) have gotten it due to their masters's mistakes or madnesses: [[spoiler:Sairin and Keiki]] get better, [[spoiler: Hourin and Kourin]] do not.

** Relena Norstein from ''Anime/DigimonSavers'', which led to her older half-brother Touma joining sides with [[SmugSnake Kurata]] to get her "cured." This is a prime example of the writers not defining the disease: she's in a wheelchair, although she can walk short distances, and [[spoiler:[[DistantFinale Touma wins the Nobel Prize for curing her]],]] but it's incredibly vague otherwise.

%%%* Rika in ''HanbunNoTsukiGaNoboruSora''.

%%%* Akiko from ''{{Itazura na Kiss}}''.

* Kotori Monou from ''Manga/{{X1999}}'' has a serious heart condition. One of her older brother Fuuma's first scenes in the manga has him reading out loud a list with the remedies that Kotori has to take that day.

* Himari Takakura from ''Anime/MawaruPenguindrum''. Her illness isn't exactly clear, but it seems to be due to a weak heart. In fact, the plot is kickstarted when [[FirstEpisodeResurrection she dies and is revived in the first episode]]. [[spoiler: And it won't be the first time she kicks it.]]

* [[YamatoNadeshiko Kikuri Tanima]] from VideoGame/TheKingOfFighters ''The Sun and the Moon ~ Prologue'' RadioDrama is the sister of [[AntiHero Iori Yagami's]] bandmate [[MsFanservice Konoe]], and she suffers more than one seizure during the drama -- one of these lands her in the hospital. [[spoiler: And she does NOT get better... in fact the CD drama is a WholeEpisodeFlashback, and Kikuri has already been dead ''for at least five years''.]]

* Oddly enough, Mai Tokiha's brother Takumi from ''Anime/MyHime'' and ''Anime/MaiOtome'' manages to fit this trope while also being a domestic type (at least in the former show), and is inordinately fond of his older sibling.

* An ill ''baby'' boy is Ivan Whisky aka Cyborg 001 from ''Manga/{{Cyborg 009}}''. [[spoiler: His enhancements somewhat cure or slowen his illness, but he's now trapped in the body of a baby forever. On the other hand, he's now a ''very'' powerful psychic.]]

* Michio Yuki from ''{{Manga/MW}}''. Not only the titular chemical warfare turned him into an asshole beyond redemption, but also gives him occasional headaches, getting hospitalized at one point, and only a few years left to live.
* Yayoi from ''{{Manga/Loveless}}'', which seems to be the result of severe athsma.

* ''Manga/BungouStrayDogs'': [[HistoricalInJoke Akutagawa Ryunosuke]] is very underweight, has a sickly appearance and frequently coughs, and a [[AlternateUniverse special spinoff]] even has him introduced as the “Prince of the School's Hospital Wing”. It's likely a ShoutOut to the author he is named after, who was psychically (and mentally) unfit for most of his life.

* In Manga/AkatsukiNoAria, both [[spoiler: Shiroyuki-sensei and his wife Kimie]] turn out to be seriously ill. In her case, [[spoiler: she already was in the last stages of tuberculosis and [[DyingAlone died alone]] in a sanatory, which is VERY messy since her family [[MistakenForCheating mistakenly thinks]] Shiroyuki was fooling around with Aria when she was dying (In reality, he was helping her out with her hand injury).]] In ''his'' case, [[spoiler: he was diagnosed with tuberculosis almost immediately after being widowed; he believes it's [[LaserGuidedKarma his punishment]] for having neglected Kimie, and he dies few later too.]]

* ''Anime/AngelicLayer'': The mother of the main character, Shuuko, is an adult Ill Girl who abandoned her daughter because she "[[HeroicSelfDeprecation didn't want to be a burden]]" and feared Misaki would be ostracized for [[ValuesDissonance having a "useless" mother]]. This gives her somewhat of an excuse for literal ParentalAbandonment, leaving Misaki in the "more capable" care of her aunt. (Meanwhile, [[spoiler:the entire Angelic Layer game is an elaborate plan coming from her friend Icchan to get enough data on human neurophysiology to cure this disease.]]) Curiously, this is not in the manga at all.

* ''VisualNovel/HoshizoraEKakaruHashi'' has two of these: one is the protagonist's little brother and the other a random village kid.

* Otohime Mutsumi from ''Manga/LoveHina'', who has a severe case of anemia and passes out almost everywhere. During her CrashIntoHello with Keitaro, she fell over, with BlankWhiteEyes ''and'' BloodFromTheMouth. Keitaro checks for a pulse...and there isn't one. Cue FreakOut. She got better, but it seems her fainting spells are closer to actually dying then "normal" fainting. Read about it [[http://www.mangareader.net/239-17287-3/love-hina/chapter-21.html here.]]

* Dr. Manga/BlackJack had ''five'' patients of this type in the new anime series:

* There are several in the Franchise/{{Gundam}} meta-series.

* Oddly enough, Mai Tokiha's brother Takumi from ''Anime/MaiHime'' and ''Anime/MaiOtome'' manages to fit this trope while also being a domestic type (at least in the former show), and is inordinately fond of his older sibling.

* ''Anime/SailorMoon S''

* Dr. Kuro Hazama aka Manga/BlackJack, thanks to [[LandMineGoesClick the hidden field mine that went BOOM on him and his mom]], killing Mrs. Hazama and severely injuring him. Of coruse, he also attends many ill boys and girls as well; in fact, regular character Sharaku was introduced as one in the newest series, since he and his sister Wakou join the cast after BJ has to operate on him in the first episode.

* In the manga ''Manga/ShinshiDoumeiCross'', the real Shizumasa Togu was an ill boy and being unable to attend school he makes his twin brother go in his place. Later chapters reveal that Shizumasa had Leukemia and had been refusing to get a life saving bone marrow transplant as he wants to die so that his twin Takanari can take his rightful place as the family heir (their family holds a test to determine the next head and when the twins took it as children, Shizumasa cheated out of fear of what would happen if he lost the test and ended up winning. However as a result Takanari was badly injured and Shizumasa would regret his actions from that point on). When Takanari learns this he gives up on his grudge against his brother and goes to the hospital to give Shizumasa the transplant he needs.

* ''Manga/MahouSenseiNegima'' has [[TheWoobie Ako Izumi]] briefly filling the role after she catches some sort of disease upon arriving in Magicus Mundus. It varies a little bit in that she gets the cure early on, but it's so expensive that it forces her and two of her friends (Natsumi Murakami and Akira Ookochi) to sell themselves into slavery. This in turn leads to Negi having to enter a tournament to win the money to buy their freedom.

* ''Manga/KatekyoHitmanReborn'': Chrome Dokuro/Nagi will die if Mukuro [[spoiler: or Daemon Spade]] isn't giving her illusionary organs to replace the ones that she lost when she was hit by a car.

* Lynn's half-sister Sarah Russell from Manga/{{Lady}} has always had a very frail health. She has to be homeschooled since she often spends her days feverish in bed, and once in a while passes out if she's too stressed. All of this messes up badly with her self-esteem, and at first she's rather mean to Lynn out of fear that, since Lynn is TheCutie, everyone else will like her better.

* One of these, Madoka [[spoiler: Shibuya]], is rather important in the BackStory of Manga/{{Zetsuai 1989}}. [[spoiler: Madoka was both a Kouji fangirl and the already fatally ill daughter of the president of Kouji's record company, and he had a PetTheDog moment by visiting her before she kicked it. Her older brother Katsumi decided to [[BecauseYouWereNiceToMe repay Kouji's kind action]] by becoming his manager.]]

* Anime/AldnoahZero has Lemrina, a teenage girl who must use a wheelchair to move around and is only able to walk ''very'' short distances when in a low gravity environment. [[spoiler: She's an illegitimate princess from Mars and, with some holographic disguises, she becomes the BodyDouble of her currently comatose older half-sister Asseylum, [[TheGloriousWarOfSisterlyRivalry whom she resents heavily]].]]

* Another adult ill boy is Kenshin's BigBrotherMentor Takasugi Shinsaku, from the Anime/RurouniKenshin ''Tsukiokuhen'' OAV. Based on [[http://en.wikipedia.org/wiki/Shinsaku_Takasugi the Real Life samurai of the same name]], who ''also'' was an ill boy. Both were affected with tuberculosis, and RK!Takasugi was almost in the last stages of his illness when he finds and recruits Kenshin into the Ishinshishi group, proved by his '''nasty''' and bloody cough. [[spoiler: Neither the real nor the fictional Takasugi lived enough to see the beginning of the Meiji restoration.]]

* ''Webcomic/AxisPowersHetalia'':

* [[spoiler: Minato]] from Anime/WishUponThePleiades is one. [[spoiler: This is the driving motivation behind his actions as Dark Star/Horned Cape.]]

* Zen Takazuchiya, a minor character in ''Manga/KamikazeKaitouJeanne'', has a heart condition and is possessed by a demon. Maron tries to checkmate the demon but is informed that the demon is what's keeping Zen alive. Maron decides she'll just wait until Zen recovers [[spoiler: but Sinbad checkmates the demon instead leading to Zen's death.]]

* Nikaidou from ''Manga/SangatsuNoLion''. He has an unspecified illness that often manifests in the form of anemia. It's frequently mentioned by members of the cast, and is something of a minor sub-plot involving him.

* ''Anime/DennouCoil'', which seems to enjoy gender-flipping a number of traditional shonen anime roles, has a sick boy in the form of Harakawa Kenichi aka "Haraken." He suffers from fainting spells and some kind of poorly-defined heart flutter that [[spoiler: may or may not have to do with his investigations into the mysterious Illegals.]]

* In ''Manga/AyashiNoCeres'', Chidori's little brother Shota is hospitalized when introduced.

** One-time character Misa-chan from the Stars season, an hospitalized little girl who bonds with Taiki/Sailor Starfighter.

* Kaoru "Kaoru-no-Kimi" Orihara from ''Manga/OniisamaE'' was held back a year due to an unspecified illness, and when the story begins she has just returned to Seiran Highschool. As such, she not only [[BerserkButton hates it when people neglect their physical well-being]], but sometimes collapses in fits of pain and needs both rest and painkillers. [[spoiler:What's her ailment? ''Breast cancer'', and she even had to go through a ''mastectomy'' at age 16, which caused her to break up with her then-boyfriend Takehiko (the titular Oniisama), and when she returned, she kept her illness a secret from most of her classmates until the symptoms of a possible relapse were shown towards the end.]] What happens to her varies according to the different continuities: [[spoiler:In both of them she goes to Germany with Takehiko after they rekindle their relationship... but while she lives on and they stay HappilyMarried [[BabiesEverAfter with a child]] in the anime, in the manga Kaoru ''does'' die two years after leaving Japan.]]