Black Mage: Let me just stop you right there before I am honor bound to cut your face like an elven whore. Thief: Hold on. Elven whore? Do I even have to tell you why that's so offensive to me? Black Mage: Look, if your mother had made dresses, I would have called her a tailor instead.
In Adventurers!, two adventurers are running from a monster and one yells at the other, "Did you have to call his mother a random encounter?"
During the gubernatorial debate in Ansem Retort, Zexion used the "you're a towel" strategy against Cid. Aerith noted it was the rich man's "your mom" joke.
In Captain SNES: The Game Masta, Amon gets enraged when Megaman uses "Your Momma" as an insult. Which is strange, because Amon is a physical incarnation, and doesn't actually have a mother.
Invoked in The Class Menagerie. Tony points out that Brad and Kevin don't like their mothers so they should come up with better insults for each other. They promptly start on "yo' roommate" insults. Tony is their roommate.
In this strip of the Dada ComicWitch's Brew, these jokes can become an unstoppable compulsion. (Your Mom is an unstoppable compulsion.) Oh, shut up. (Your Mom should shut up.)
In thisDoodle for Food comic, a game show contestant answers the question "What is the largest mammal on Earth?" with "Is it your mom?" Lucky for her, the game show host is a blue whale, so that's the correct answer.
Kiel'ndia in Drowtales uses this against Chiri'nide as they fight here and here, and Chiri being Chiri, it works perfectly.
Becca: I hear a lot of talk, but I don't see a lot of action! Zoe: Your mother doesn't see a lot of action. Bob: Oh, come on now. Fighting is one thing, but mother jokes? Aren't we a little old for that? Zoe: Your mother's a little old for that.
Ah — go kees an hoctopoos. Oh vait, hyu mama already deed! Heh.
The Baron's dragon unleashesFlowery Insults on Franz Scorchman, including telling his squire (who rides a donkey) "If superficial resemblances are all it takes, then you sit astride his dam!"
Played with in Girls with Slingshots: Hazel asks Jamie who will arrange the upcoming party. When Jamie truthfully responds "Your mom!" Hazel gets it wrong and irritably retorts "Your mom!" (The joke is recycled from here.)
When discussing briefing the President on a disaster:
TG: like mr president theres a meteor coming sir. oh yeah, how big is it? its the size of texas sir TG: OH SHIT TG: or, how big is it? its the size of new york city sir TG: OH SHIT TG: sir im afraid the comet is the size of your moms dick TG: OH SNAP
In another conversation, Dave anticipates the "face" variant:
TG: how does that even work TG: how do you use a computer and know whats going on it doesnt make sense TG: my face doesnt make sense GC: D4V3 YOUR *F4C3* DO3SNT M4K3 ...... GC: D4MM1T
In a later conversation, the trope is defied:
Dave: ill be the ambassador to your mom. Dave: and no that wasnt actually meant as the sick burn it sounded like
In Jailhouse Blues (a former subcomic of Bob and George), Yo Momma Man reveals that he's programmed to reflexively respond to any insult with "Yo momma!"
Ocelot and Liquid try to explain how "your mother's a whore" is the highest insult possible, and wonder why they couldn't just skip ahead to that.
Later, when Wolf and Ocelot realize they were flirting with each other, Wolf declares they must insult each other. Of course, given who Ocelot's mother is, she may want to take that back.
Wolf: Your mozer's a whore. Ocelot: Thanks! Yours too.
Mantis then gets in on the action:
Mantis: I hear the blond one is Solid Snake's brother. Ocelot: No kidding! Does he know that? Mantis: Let's see... (reads mind) Nope, doesn't have a clue. Ocelot: Are you sure? Try probing a bit deeper. Mantis: If I go any deeper I could cause serious damage. Ocelot: That's funny — I said the same thing to your mother last night. Mantis:(death glare) Ocelot:In bed Mantis:(throws potted plant at Ocelot)
My Mamma is In — Burned is Out!: One of the soyjaks proposes the usage of "Yo Mamma" as the new "Coal" because she's fat, constantly has sex with him even though she's post-menopause and the other one's father is still alive, and she birthed the other aforementioned soyjak.
Roy tries to get the Oracle's attention while incorporeal with "yo mama" insults. The Oracle turns it around a few comics later, since he actually could hear them:
Oracle: ...Who may have been a bit portly due to a glandular condition, but at least she didn't whore up the Afterlife when she died...
When Elan and Nale square off, Elan drops some insults to Nale's mother as a distraction. Nale's distracted more by the fact that she's Elan's mother too.
Tycho: I feel like there's a disconnect between the shit talking and, you know... Armello's general aesthetic. Gabe: Oh yeah? I feel like there's a disconnect between your mom and my dick. ...Hmm. That one needed a little more time in the oven.
In Persona 3 FTW, this was Aigis's response to Akihiko as to why she, a robot, couldn't open a door.
In Pokémon-X, May is being pestered by the NPCs of Dewford, who go on and on about "Invincible Legend" and how awesome it is. Eventually, she snaps and tells one of them that the real big thing is "your mother". The NPC takes her at her word, and when Brendan explores the town, he hears everyone talking about "your mother" and thinks they're the rudest group of people he's ever met. As the comic writer points out, this is actually possible in the games on which the comic is based.
In a montage of partying physicists in Questionable Content, we see a drunken argument where one astrophysicist tells another he couldn't read the spectra from galaxy NGC 1041 if it was tattooed on his retinas, and gets the reply "Oh, yeah? Well, I read your mom's spectra last night!"
Dirk: You couldn't get me even if you brought your ma's bridge club. Troll:My ma don't have no bridge club. Dirk: So how does she defend the bridge she lives under, then? Troll:My ma don't live under no bridge, dude!
In Sabrina Online, Zig Zag goes so far as to actually sleep with an internet troll's mother.
The Devil: Yo mama so fat she always wins at see-saw. Yo mama so fat NASA upgraded her to planet status! Oh! Burn! Jesus: Verily I say unto thee: Thy mother is so gluttonous she doth bear the mark of Chef Boyardee upon her flesh. Oh, snappeth!
One of the backer rewards in the Volume 3 physical book Kickstarter was to ask the characters three questions, which would be answered by exclusive marginalia in that backer's copy of the book. Among the ones shown on the website was Nick being asked about a good Valentine's Day movie and replying "Aliens, 'cuz it gets your mom in the mood. I guess she likes that stuff." (Dr. Lee then revealed it was actuallyLadyhawke.)
Nick again, when Moustachio finds him in a funk (and not the Tigerlily kind):
Moustachio: Is this regarding Dr. Lee? Nick: What?! No! Dr. Lee? Your mom's Dr. Lee! Moustachio:I can gauge your feelings, and my empathy is two springs and a Vial of Mercury. Nick: Your mom's a vial of mercury!
Officer Tod throws around an absurd number of these during the final battle of Sluggy Freelance's "Phoenix Rising" story arc. An example:
Boy: Well, your mom turns every conversation into a "your mom" joke and it's becoming unbearable. Girl: I'm serious; I can't take this anymore. I'm leaving. Boy: ...That's whatshesaid! Girl: Yes. Yes, it is. [Alt Text] Girl: Seriously, it's your mom jokes or me. Boy: Then I, like so many men before me, must reluctantly choose your mom.
In #502, Beret Guy takes it unusually — Cueball suggests that a supermassive object beyond the edge of the visible universe is "your mom", only for Beret Guy to look to the sky with a telescope:
"It means four extra hours daily. You can stay up until you're exhausted and then spend a full 9 hours asleep each night!" "But how much time can I spend doing your mom?" "You? I'm guessing three or four minutes, tops." "...Well played."