Awesome Music: It's hard not to like at least one version of "Little Boxes".
Almost every episode has a lyrically appropriate song for the last few seconds of the show that run into the credits. It's almost always awesome.
Big-Lipped Alligator Moment: In season five, Nancy asking Andy to suckle her. Subverted in that it is mentioned once later in the episode, but then, never again.
Ensemble Dark Horse: Despite her mastery of the art of Being a Bitch, Celia still manages to be one of the most popular side characters.
Fridge Logic: If Nancy had sold the house in Agrestic back in 2005-06 when the real estate market was high, she'd have been at least free and clear with enough for a halfway decent place elsewhere, if not a nice nest egg on top of that...
Doug's son Josh was revealed to be living in Chicago. Josh was played by Justin Chatwin in the Pilot, and he later went on to star in the Foreign Remake of Shameless, which takes place in Chicago.
It is revealed in the finale that Isabelle has undergone sex reassignment surgery and is now named Bruce. A few years later, and one of the most public and high-profile transitions is that of Caitlyn Jenner, formerly Bruce.
One of the episodes of season 4 is titled "I amthe Table".
Seasonal Rot: Generally considered to have gone astray after season 3 or during season 4. Whether or not it jumped back is highly, highly debated.
The Scrappy: Silas seems to be headed this way in season 7; Jill and her twin daughters are ones as well.
Rescued from the Scrappy Heap: In the final season, Silas and Jill manage to make good on their part of the "compromise" mentioned at the end of Season 7, with Jill and Nancy making amends and the former giving Nancy custody of Stevie without complaint, and Silas showing himself to be a dedicated and loving son to Nancy and brother to Shane when it really matters.
Tear Jerker: The ending of the series, for both the obvious and not-so-obvious reasons.
Unpopular Popular Character: Celia. Nobody in-universe likes her, least of all her husband and children, but she's one of the show's most popular characters with fans and critics.