- Complete Monster: Kisaragi is the head of Daiwa Heavy Industries, and the mastermind behind all the evil in the story. Using Daiwa, Kisaragi manipulates the population of Japan into getting vaccinated for a virus of his own making, the people unaware that the vaccination itself is a technovirus that will slowly and agonizingly transform their every cell into technology, eventually eating their brain and turning them into mindless zombies under his control. Running no tests beforehand, Kisaragi is fully aware that the virus is killing most of the infected, turning them into shrieking, metallic monsters known as Jags, and is amused at the fact that they annihilate all in their path. Within ten years, all of Japan's millions of citizens except a few thousand are either dead or Jags, and Kisaragi manipulates the last of the population into slowly being turned into his robotic slaves, revealing that he plans to continue his experiments on all of America, knowing most of its population will die as well, before moving on to infect the entire world, using his new mechanically "evolved" humanity to set himself up as the god he believes himself to be. An utter hypocrite as well, Kisaragi was too cowardly to even turn himself into a machine, as he claims to have done alongside his Dragon as a preliminary test, and coldly guns down said Dragon when he expresses outrage at Kisaragi's hypocrisy. A smug, narcissistic sociopath, Kisaragi believed that his vision for humanity was the true future, and was willing to doom millions, all to test his plans to turn humanity into his worshiping slaves.
- Memetic Mutation: This particular screencap◊ of a choice quote from Kisaragi, which is often used to mock obsessive Japanophiles.
- Spiritual Successor: To the first Appleseed movie.
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