On the other hand, Jim explicitly contrasts himself to the other guys by calling himself a "nice guy", and complaining that "nice guys don't get laid", clearly implying that the other guys are only getting laid because they aren't nice guys. Later on, Chris (feeling bad about the whole Jim thing) admits to Jim that he has nothing against him. Jim resentfully calls the other guys "assholes", and when Chris points out that just because they don't like him, it doesn't make them assholes, Jim retorts "If they were decent they would have at least tried to like me." This after Jim has insulted them to their faces. In any case, the debate about the sort of character Jim was intended to be, and how he comes across, continues.
All the early strips with the Unresolved Sexual Tension between Hazel and Zach and when they get a Relationship Upgrade come off as this, knowing how their relationship is going to turn out.
Angel's belief that lesbians cannot give each other STDs, cue the first documented AIDS transmission from woman to woman.
Moral Event Horizon: Candy crosses this when she attempts to sabotage Jameson and Maureen's wedding.
The Woobie: Thea is heading toward this territory. Loses her job: check. Sister has cancer: check. Girl she's taken with uses her for sex and exposes her to an STD: check. Yup, we've got ourselves a woobie.
. However some people feel that by placing him next to Chris