Heartwarming Moments: Practically every one of Big and Small's Friendship Songs are heartwarming in some way, but the song "Friends Forever" deserves a special mention due to how genuine they are and the Clipshow in the first verse.
Memetic Mutation: "Uh-oh, you found the toothpaste! Let's get one thing clear, I can brush my teeth all by myself, okay!"Explanation One of their Flash games on the old CBeebies website included a segment where Big and Small brush each others' teeth in the bathroom. Small's segment (which may start with the above quote) looks less like Big is cleaning his teeth and more like Big is trying to waterboard him with toothpaste, due to how he's forcefully shoving the toothbrush down his (entirely toothless) throat while Small coughs, spits, and chokes the whole time. The moment quickly got memed on thanks to how offputting and darkly hilarious it is in contrast with everything else.
Visual Effects of Awesome: The show's puppetry is absolutely stunning. Most of the full-body shots utilize green screen and have incredibly detailed articulation that is barely seen in most Puppet Shows.