- Half confirmed, half jossed as of the sequel. Pikachu wasn't literally transformed from a human, but he does have the human Harry's mind currently occupying his body.
- This bossy Pikachu has the attitude of a stern, middle-aged man, which he’ll make abundantly clear to you throughout the game.
- Jossed, at least for the Mewtwo switching them back part.
- Mostly confirmed on the consciousness part, though. It turns out that both Harry and Pikachu's minds are currently in Pikachu, which is why Pikachu can't remember anything, and Mewtwo can separate them, but Harry chooses not at the moment since it's too risky.
- You... can't... I.. won't... let... you... Pika… Piiiikaaaachuuuu!
Unlike previous moments in the game where we've heard this, we haven't changed viewpoint, yet Pokémon Speak is in full force. Moreover, when Tim asks Detective Pikachu about his Thunderbolt the next morning, Detective Pikachu has no idea what he's talking about. Combined with Mewtwo saying that his bargain was made with "the real you" when talking to Detective Pikachu, this may indicate that Harry and Pikachu are operating the same brain, but not at the same time — the "processing space" can only be occupied by one personality at a time, and that's usually Harry's, with Pikachu only surfacing in moments of extreme pain, as when he was being pummeled by Noivern's sound waves, in order to use Moves.
- Confirmed in the sequel. Harry is indeed occupying Pikachu's mind, and Pikachu is heavily implied to have taken back over during that scene, as Mewtwo states that Pikachu having used a move makes the competing consciousnesses even more complicated and risky than they already are. The "original" Pikachu is also the one who begged Mewtwo to put Harry's mind in his body.
- Disregarding feelings about the anime, having the original talking Pokemon react to a talking Pikachu would likely be too good for the devs to pass up.
- Unfortunately jossed. Although there is a reference to the anime in the form of Detective Pikachu meeting a different one who is implied to be Ash's Pikachu.
- Looker. One of the most popular characters from the games, as well as a fellow detective. Could tie into the oft-speculated Diamond and Pearl remakes. Although we don't know Looker's real name, Tim is unlikely to be a young Looker (partially because the game features Kalos Pokémon, which came after Diamond and Pearl (unless the remakes are subject to a Retcon.)
- Cosplay Pikachu / Pikachu Libre: Detective Pikachu could team up with her in a Brains and Brawn duo.
- Ukulele Pichu: Detective Pikachu could team up with this Musical Assassin too.
- Jossed, in keeping with Pokémon's traditions, all the villainous characters are humans. Although Mewtwo does play an important part.
- David Caruso
- Kevin Conroy
- Benedict Cumberbatch
- Danny Devito
- Mark Hamill
- Christopher Meloni
- Jonny Lee Miller
- Johnny Yong Bosch
- Matthew Mercer
- Colin Mochrie (as a reference to Whose Line Is It Anyway? and their "Narrate" game)
- Jossed, it's Kaiji Tang.
- Expect to have a possible cameo of Jessie, James and the Talking Meowth.
- Jossed, Team Rocket never shows up in either game.
- It's called Detective Pikachu! He should not evolve!