- Acting for Two: Charlie Adler and Tress MacNeille voice both Buster and Babs Bunny and Zag and Zig.
- Creator-Driven Successor: The game features similar gameplay to Rakugaki Showtime, another fighting game by Treasure that focuses on throwing objects at your opponents.
- The Other Darrin: The game has the distinction of the original voice cast coming back to reprise their roles (including Charlie Adler, for the first time since 1992). With the passing of Don Messick in 1997, Billy West provides the voice of Hamton. He also replaces Frank Welker as Maximus Flush.
- What Could Have Been: The game's original titles were Tiny Toon Adventures: Defenders of the Loony-verse and Tiny Toon Adventures: ACME Invasions.
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