- Career Resurrection: Brian Benben had been a huge star in the 90s with Dream On but had very much faded afterwards, this show putting him back in the limelight once more.
- Fake American: Alex Kingston as Marla.
- Playing Against Type: Nicholas Brendon, the heroic, goofy Xander from 'Buffy the Vampire Slayer' is now evil rapist Lee McHenry.
- Reality Subtext: Amelia became pregnant in season five because of Caterina Scorsone's pregnancy.
- You Look Familiar: Actress Jana Kramer appeared on Grey's Anatomy in the Season 4 finale. A year later she appeared in an episode of this series as a different character.
- Sarah Drew plays a pregnant teen in season 2 before later joining the main cast of Grey's as April Kepner.
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