- Breakthrough Hit: For John Hughes as a writer.
- One-Take Wonder: According to Jeffrey Tambor, the shot of Michael Keaton knocking him out was done in one take.
- Recycled: The Series: Only a year after this movie was released, a spin-off television movie version was made. It had a different cast and crew, except for John Hughes and director Stan Dragoti, who were credited for characters and story, respectively.
- In 2019 there was a series produced for the streaming service VUDU, in which the adult version of Megan (Jack and Caroline's daughter) returns to the workforce, and her husband takes on household duties.
- What Could Have Been:
- Ron Howard was asked to direct, but he turned it down in favour of Splash.
- Chevy Chase, Michael Douglas, John Goodman, Steve Martin, George Segal, John Travolta and Robin Williams were considered for Jack Butler.
- Karen Allen, Jane Curtin, Farrah Fawcett and Sally Field were considered for Caroline.
- Jeffrey Jones, Jack Nicholson and Burt Reynolds were considered for Ron Richardson.
- Write What You Know: The premise came about when John Hughes told producer Lauren Shuler about a disastrous experience he had looking after his two children in the absence of his wife, which Shuler found hilarious. After asking if that could make a good movie, she replied that "it sure sounds funny to me".
- Written for My Kids: Aaron Spelling recounted in his memoir:I couldn't find a film that was suitable to take my kids to, so we made one.
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