- Dueling Movies: Killers came out around the same time as Knight and Day, which has a similar plot of an agent falling for a clueless civilian blonde girl.
- Playing Against Type:
- Ashton Kutcher as an action hero.
- Almost all the assassins are played by comic actors. A couple having even featured on Saturday Night Live.
- Star-Derailing Role: Killers more or less destroyed whatever remained of Tom Selleck's movie career, though his television career is still alive and kicking thanks to Blue Bloods.
