- Descended Creator: Frank Peretti plays Dr. Algernon Wheeling, a scientist who helps analyze the samples and develop an antivenin for the spiders.
- Enforced Method Acting: The actor who plays Coach Marquardt is arachnophobic as revealed in one of the behind-the-scenes featurettes. His panicked reactions to spiders crawling over him were kept for the film.
- Featured in Episode 108 of the podcast God Awful Movies.
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