- Deleted Scene: A scene cut but kept as an extra for the DVD release had the Doctor reveal he was a part of the writing of the United States Declaration of Independence. He even kept a copy of the first draft in his pocket. This also led into an outtake where the Doctor unfolds the document, only for David Tennant to realise that he and Freema Agyeman are off-screen.
- Doubling for London: Wells Cathedral in Somerset doubled for Southwark Cathedral.
- Prop Recycling: A little known fact for The League of Gentlemen fans is that the wig worn by Mark Gatiss in this episode is the same one he wears for the part of Mr. Chinnery.
- Recycled Set: The set piece for the capsule of Lazarus's Genetic Manipulation Device is actually the redecorated descent capsule from "The Impossible Planet/The Satan Pit".
- What Could Have Been:
- Lazarus was originally working on developing invulnerable synthetic skin. This was dropped because Russell T Davies worried that this might be part of the plot of Spider-Man 3, which was due for release in May 2007, around the same time that the episode would likely air.
- Lazarus was originally named Professor Anger.
- Working Title: The Madness of Professor Lazarus.
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