Tear Jerker / The Legend of Zelda: A Link to the Past

• The death of Link's Uncle at the beginning of the game —
  Link's Uncle: Link... you must rescue Princess Zelda. Our people are fated to do so. But do not fall victim... to fate... Link...
  I shall always remember... our time... together...
• The Flute Boy scene. He can't play his flute anymore and asks Link to play it for him. Then he turns into a tree.
  • When you tell his father:
    "I just wish I could have seen him... one more time."
• The credits music. Holy shit, that credits music.
• The scene that plays if you return to the Sanctuary after getting the Master Sword. There, Link finds the Sanctuary ransacked, with Zelda kidnapped to be used as a sacrifice by Agahnim, and the Sanctuary Keeper fatally wounded.
• The fact that this is the first game in the official timeline that takes place in the era where the Hero of Time is defeated by Ganon. The weight of this game becomes a lot more harrowing when you realize the most iconic incarnation of the hero's legacy had to lose in order for it to happen.