The episode "Millionaire Astro" has quite a bunch of sad moments, but especially when it seems that Astro is sent to live with millionaire J.P. Gottrockets and the entire family tearfully bids him farewell:
George:(tearfully) So long, Astro. (sniffles)
Jane: Goodbye, Astro! (sniffles)
Judy: It won't be so bad... (sniffles) You'll be a rich dog from now on.
Elroy: Yeah... and we'll visit you any chance we got, Astro. (weeps)
The episode "Elroy's Mob", when Elroy runs away because his family (mostly George) refuse to believe that he didn't get low marks in his report tape.
When Jane and George find out that Elroy was telling the truth, George felt the most guilty for not believing Elroy and punishing him.
In "Elroy Meets Orbitty", Astro spends most of the episode in a funk because he's jealous of Orbitty and because Orbitty ate his food and caught the stick first in a game of fetch. He then imagines Orbitty replacing him in the family photo and leaves home. When he comes back, Orbitty leaves home, but luckily, he comes back and the two pets make friends.
In "Rosie, Come Home", Rosie thinks the family don't need her anymore and leaves home. She then stands in the rain and cries.
In one episode, George creates a clone of himself, with additional skill and intelligence put in, making him an Ace. He's so good at being a patriarch that George himself decides to let the clone be with his family, while he himself signs up for military enlistment.
In "A Jetson Christmas Carol", Astro becomes deathly ill from choking on a Spacely Sprocket. The Ghost of Christmas Present shows him how the family is dealing with this, with Jane and Judy crying into George's arms:
George: I'm afraid this isn't going to be a very merry Christmas... we better be prepared for the worst.
Jane:(crying) Oh, George, no!
Judy: This is the saddest Christmas— (sniffles) —we've ever had!
