Eva expressing sorrow over her inability to control herself, which occurs shortly before her death. She used to be a regular girl who wrote sad songs before she found out she was a goddess. That scene is especially sad because it's a rather cute and heartwarming scene between her and Ty; if they were mortal, they'd probably be a perfectly happy couple. But they each bring out the worst aspects of their god-spirits, leading them to more and more self-destructive behavior.
Just seeing what Eva made Ty into is pretty tough. He was always the odd one out when it came to his brothers, but when they go and visit him, he's in a complete daze, out of his mind on drugs, and clearly slowly killing himself.
Season 2
Axl and Gaia's frantic and completely doomed attempts to salvage their relationship despite the fact that she can't stop having sex with Anders. The way she describes her loss of control sounds like flat-out Demonic Possession.
Gaia:[crying and blubbering]I hate him so much but this thing inside me wants him and it's stronger than me and I can't stop it—
Axl standing on a rooftop, screaming about how depressed he is now that Gaia has left, and that its all Anders fault while his three brothers watched horrified from below, realising that if they don't do something soon, its very possible their baby brother might jump.
Especially tough for Anders, as pretty much all of Axl's pain is a direct result of his actions, and Axl lets him know it.
Season 3
After Michele dies and is brought back, but told she won't survive the Agar, Mike finds her curled up on his bed, despite the fact that they're broken up. She has nowhere else to go.
Dawn post-Agar. There aren't any words said, but you can just tell how depressed she is over losing someone she doesn't even remember.
