WARNING: Spoilers Off applies to Moments pages. All spoilers will be unmarked.
- Watching Francis and Bash's relationship go sour because of the love triangle and succession issues.
- Leith being sent away from the palace while Greer watches from afar.
- Greer crying when she and Leith mutually reject each other.
- Henry's death, in which he shows great empathy and compassion to his family in his final moments as he never had when he was living and confesses to murdering his older brother. Worse yet, Francis is the one who killed him (in disguise) and the guilt starts to eat at him. Francis storms out of the sickroom nearly in tears and across from him is Bash, who came to see their father one last time only to hear that he's already dead. Bash kneels before his brother, but Francis lifts him up and hugs him tightly.
- The whole story arc surrounding Mary being raped: the scene itself, her Heroic BSoD, Catherine using her own experience to help her through it, her having to pretend that nothing happened to save face, Francis's guilt for the role he played in it, her anger at him for the very same, everyone being really worried about her, and the subsequent psychological issues she develops because of it. To add salt to that wound, just as she's ready to reconcile with Francis, she finds him asleep with Lola and their son.
- Francis's death. The entire scene of his actual death, with Mary's abruptly more serious face and tone when he drops to the ground; his speech to Mary about how she has brought him so much, Mary begging him not to leave her as she clings to him.
- And then, when Catherine and Bash arrive, they find Mary sitting next to him, just holding his hand, and the usually callous Catherine gently urges Mary to get up, telling her that Francis is gone.
- As if this wasn't bad enough, a distraught Mary storms into the English ambassador's room, ranting desperately about how Elizabeth must have planned this, ignoring the reasonable argument of the ambassador that it would be downright stupid of Elizabeth to kill another monarch, and besides, Elizabeth has gotten what she wanted from Mary. Mary decides to rip up the document with her signature on it and burn it.Mary: England has taken enough from me this day.
- When the ambassador attempts to protest, Mary snarls, "It is your word against mine!" The really sad thing about this scene is that Mary is still in tears throughout it, she seems truly desperate for someone to blame, and worst of all, you can still see Francis's blood on her apron.Mary: I have been left with nothing!
- This scene is pretty bad, but even worse; she runs out into the darkened throne room, tear-stained, half-sobbing, wearing a bloodied dress with her hair unkempt, and she tears down the banners with England's coat of arms before screaming from the middle of the room. It's heartbreaking.
- The death of Lola, on multiple levels. First, the actual execution scene, as she's on the block, telling Narcisse to care for her son and crying even as she faces her fate. Then, her husband, realizing at last how much she means to him, charging at her, stabbing some guards before being tackled and forced to watch Lola be beheaded. Then, Mary's reaction upon hearing the news, sobbing at the loss of her friend and shaken by what it means.
- The worst part of it all is that Lola had no idea that the orders to kill Elizabeth came not from Mary but from Knox, faking the code to set her up, all as part of his wider scheme to set Elizabeth and Mary against each other in his hopes of turning Scotland into a democracy. Thus, Lola was convinced she'd been fighting for her queen and going to her death having done her duty, unaware she'd been nothing but a pawn in a man's scheme.
- In the aftermath of Lola's death, Narcisse goes on the warpath in Scotland and ignores Mary's orders to stay away from John Knox, the man responsible for his wife's death. Unable to let go, he kidnaps the preacher and tortures him with castration, all the while telling Knox how he loved Lola "more than life itself". If you think that wasn't tearjerking, it gets worse. Once he's done with Knox, he brings John Phillip home to his grandmother, Catherine, in France. As the boy's stepfather, she offers him parental rights to John Phillip - but Narcisse adamantly refuses. The reason? Because John Phillip has Lola's eyes and he can't help but see so much of her in him to the point that it was painful.
- The death of Gideon's daughter, just as the girl had enjoyed a wonderful day as "princess" in the court. Elizabeth can't hold back tears as she embraces Gideon in a chapel.
- Elizabeth ripping her father's portrait off the wall in a fit of grief and anger, railing at him for his treatment of her in her youth before breaking down into tears.Elizabeth: Damn your ego! (throws Henry's portrait to the floor) Insisting on having a son when you had me! Your own flesh and blood!
- The final scene. After all her fights, all her struggles, everything, Mary is framed for treason and beheaded in 1587. Her eyes open to find herself in bed with Francis, who tells her that he's been waiting for her and "this is real." The two then joyfully run through the forests, holding hands, at long last reunited for eternity; a montage of the best moments from the series plays for the viewer while they do.
