Per wiki policy, Spoilers Off applies here and all spoilers are unmarked. You Have Been Warned.
Muhyo and Roji being a series in which many people meet untimely demises, naturally has no shortage of tear jerkers for the dead or the living.
- Nana's father getting sentenced to Purgatory while making a final show of affection for his daughter by patting her forehead, the only way he can do as he is.
- Some time after Rio's mother died, Biko expresses her concern about her, and offers to be there for her. Unfortunately, Rio had already joined Ark, and while she appreciates Biko's gesture, she realizes it's too late. Cut to the present, when Rio tells Biko that she wished they'd had that conversation sooner before continuing the battle against Muhyo and the other heroes.
- The fates of Ai and her mother. They were desperately poor, so much that Ai's mother couldn't afford to buy a doll for her, let alone rent an apartment in the planned new luxury apartment complex. Shortly after Ai's mother made her daughter a doll, Ai dies in a car accident. The last time Ai's mother is seen alive, she's emaciated, and madly trying to make additional dolls for her daughter in the vain hope of her returning.
- The outcome of the contest between Muhyo and Ebisu, in which neither side truly wins. Muhyo, having lost on a technicality, ends up surrendering his office to Goryo. Roji, having failed to understand what he needs to, is put on leave to improve himself. Nana is unable to see her new friends for the foreseeable future, partly because they're busy and partly because Muhyo and Roji can't see past clients unless they have a new case. Even Goryo and Ebisu aren't any better off; Goryo fires Ebisu for failing Maneuver 108, and feels no satisfaction in the victory.
- After Muhyo puts Roji on leave, Roji desperately reminds Muhyo that he promised to help Rio, only for Muhyo to brush him off and say that he'll handle it with Biko and Yoichi. While Roji later realizes that he was so desperate for Muhyo's acknowledgment that he wasn't thinking about what he could do to help him, Roji is serious about his promises, and it's depressing to see his genuine offer of help rebuffed.
- Ivy's death. After losing to Goryo and Ebisu, she ends up being callously murdered by one of her former allies and Dying Alone, unable to see her only living sibling again.
- Kid's death, particularly when he admits the error of his ways and states that he wanted to see his parents again, but will see his parents and siblings again in the afterlife. This is one of the most moving moments of the manga.
- At the end of volume 15 after Enchu is freed from Teeki and turns to the good side, and is subsequently sentenced to life in the Arcanum.
- Yuki Otada's backstory, a Kids Are Cruel moment of the highest order. He was mercilessly bullied for his size by his classmate, and lost the dog who was his only friend. He had a Hope Spot when his bullies apologized to him, but that was snatched away when he realized that the addresses they gave him were fake and that they were playing a prank on him, leading him to be Driven to Suicide. To put things into perspective, Muhyo, despite having to sentence him to Hell, takes pity on him enough to give him a Lotus-Eater Machine on his way down. In the end, Muhyo, whose mood generally alternates between snarky and comically angry, can only say that "Some kids have it tough," with a forlorn expression on his face.
- Roji is offered a chance to stay as Muhyo's assistant by earning a promotion to First Clerk, only to fail the exam as a result of spending too much time carrying an examinee to safety. As a result, Imai, a Tsundere with a soft spot for Roji actually breaks down crying at the news. This is followed by a three day-long Hope Spot in which Roji waits for news of the result, only to get a document stamped with two words- "Advancement denied."
- The author's note at the end of the last volume.
