Tear Jerker / Diablo IV

• After the player kills Vhenard, Neyrelle shows her grief.
  "You were— you were protecting me. I don't want to hate you. I'm trying. I really am".
• Vigo's last moments. What Prava made him to do is terrible enough, but Vigo also adds to this asking the player to give Neyrelle back her mother's necklace (ironic, as she bribed him with it and that caused the whole tragedy) and relief he finally penitented. The player lying to him the light is coming to take him is just too much.
• She might be the Big Bad, but Lilith's last words for her son Rathma are still really quite moving.
  "I don't know if you would have chosen to stand beside me in this new world, Rathma, but I would have saved your place just the same."
• Inarius and Lilith during their final confrontation:
  • Inarius exclaims that Sanctuary (and humanity in general) is an abomination. Lilith sorrowfully asks in response that if he also thinks that their son, Rathma, was an abomination. The tone in Lilith's voice makes it clear that she is still mourning her son's demise as well as calling out her former spouse for murdering their firstborn child.
    • It's clear by Inarius's tone of voice and brief hesitation upon Lilith calling him out that he regrets killing Rathma, but feels like he had no choice if he wanted to return home.
  • Inarius is clearly in just as much pain as his ex-wife in this encounter, showing just how much her betrayal and the torture he endured for millennia at the hands of her father, Mephisto, have affected him. Gone is the great man who sought peace after a lifetime of war and envisioned a world where Angel and Demon could live together in peace; now there is only a broken shell that desperately seeks to return home after all this time and is trying to destroy all that he built in order to earn the forgiveness of the High Heavens; a forgiveness which Lilith coldly confirms the Angiris Council will never bestow. For all of his crimes, it is hard not to pity him as he dies at the hands of Lilith, who he once loved more than anything in Creation, begging for his former brothers and sisters to save him to no avail.
• Donan's entire story. Man's a hero who saved his people from a demon. Then Lilith shows up and because he refused her, she has his castle destroyed, his son killed and turned into Astaroth's vessel, and the capital damaged. She makes sure Donan sees it. The revelation that Astaroth was Not Quite Dead causes a large portion of his people to turn on him, blaming him for the death and damage caused by Astaroth's brief return. Donan, now broken, joins the party, and has to go through a Mushroom Samba to tearfully come to terms with his son's death. He ultimately gives his life on the quest to stop Lilith.
  • Astaroth twisting the knife when Donan realizes he was too late to save his son certainly doesn't help.
  "He called out for you... wept until his tears became fire."
• The Post-Final Boss battle with Iosef, the same priest who helped you escape Nevesk in the prologue. Its clear that neither you or him actually want to fight the other, but Iosef has his orders, and you're not about to let Lorath die. After the battle is over, the Wanderer mourns Iosef, musing about how senseless the fight was and cursing Prava for forcing them and Iosef into a situation where one had to kill the other.
• We finally discover the fate of II's Paladin, here named Carthas. It turns out that killing Sankekur in order to defeat Mephisto, as well as the fall of the Zakarum in general, broke him both spiritually and mentally, and he spent the rest of his life guarding Sankekur's remains in the Durance of Hate. The Wanderer puts his spirit at peace, but this means that Carthas shares the same fate as the first Diablo heroes amongst the other Diablo II who somehow had better fates (like Xul the Necromancer and Cassia the Amazon. Even Isendra the Sorceress spares you from having to kill her yourself). Slightly mitigated that Carthas made his choice to seal himself and his men within the burial grounds knowing that he'll succumb anyway, so that others would not be a recipient of his later wrath (and in general, he fared better than Aidan, he successfully kept his wrath sealed instead of spreading it throughout the Sanctuary), but even one can shed tear on that decision of sacrificing himself in the face of inevitable doom for the greater good.
• The Crusader is confirmed to have died fighting Demons in the interm between III and IV. Slightly mitigated by the fact that you're able to help her apprentice retrieve her armor and take up her name as per Crusader tradition.
• The Heretic questline. Aneta was born under a blood moon with foul magics that are inherent to her blood. Because of this, everyone in her life - from the townsfolk to even her own mother - view her as nothing more than a heretic that must be killed. Even as Aneta's mother dies of her illness, Aneta wants nothing more than for her to get better. It gets better a bit when Gulyas points out that Aneta is in fact a witch - but that she doesn't have to use her powers for bad - Aneta agrees. Even despite her mother leading a literal hate mob to kill her, Aneta still begs for her mom not to die in her hands and to heal her. Aneta finally decides that enough is enough and... just leaves. But not before leaving a goodbye letter with Gulyas. Of the only people in her life, you're the only two who ever saw her as a person and wanted to help. Time and time again, you still protected her and defended Aneta. No matter what, she never decided Then Let Me Be Evil.
• The Remembering The Goose sidequest in Scosglen. The sign of the Under the Fat Goose Inn was stolen by two teenage troublemakers, and the innkeeper asks you to get it back. When you track them down, you only find one of the teens, clearly drunk off her ass, who reveals that the other teen was murdered by Khazra and she took the sign as part of her desire to honor her friend by fulfilling his Last Request to place his daggers at several dangerous locales to prove his bravery. After helping her plant the daggers, she admits that she deeply misses her companion, thanks you for your help, and gives you back the inn sign before asking you to leave her to her drinking. Even the innkeeper is saddened when he learns of the partner's death, admitting that the two of them helped bring entertainment to the inn with their mischief.
• A quest in the Fractured Peaks has a man tormented by the spirit of his son, who passed away in an asylum he was sent to after having murdered another boy, and he begs you to put his son's spirit to rest. When you enter the Asylum and find the son's ghost, he laments how his father had promised to visit him in the asylum but never did, and devolves into screaming about how "father lied" before attacking you. After the ghost is destroyed and you report back to the father, he simply shuts down in grief before revealing the truth: He caused the other boy's death (heavily implied to have been a complete accident) and convinced his son to take the fall, promising to visit him and find a way to get him out, but as is obvious now, never did. Cursing his own cowardice, he resolves to enter the Asylum himself and "see his son". The implications are as obvious as they are grim.
• After you first meet the Tree of Whispers, as you leave the area you can stumble across the ghost of a weeping child, who beckons you to follow him. If you do so, you'll eventually find his corpse, having been poisoned to death by snakes. You can then find the boy's father in Wejinhani, and when you tell him the horrible news, he is devastated.