In Xion's ending of Bloody Roar 4, Nagi (possessed by the Unborn) murders Ryoho in front of Mana. Keep in mind that Ryoho is Mana's only parental figure at that point. Although she was able to help Xion and Nagi to overcome and destroy the Unborn spirit that possessed them, it doesn't help that she started howling in front of her dead foster father's corpse. Probably the only effective tear jerker in the whole game.
http://tvtropes.org/pmwiki/pmwiki.php/TearJerker/BloodyRoar
FollowingTear Jerker / Bloody Roar
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