- Godzilla: Singular Point: The "The Tyger" poem is discussed in Episode 6, while solving the meaning of "fearful symmetry" from Professor Ashihara's notes regarding space-time.
- From Hell reveals that his famous portrait of a monster "The Ghost of a Flea" was actually a portrait of the ghost of Sir William Gull, aka Jack the Ripper. Earlier in the novel, Gull visits his grave and explains the mystical significance of his works to his sidekick, Netley.
- Watchmen the fifth issue's title is a reference to "The Tyger'': "Thy Fearful Symmetry"
- In the Spider-Man story Kraven's Last Hunt, quotations from "The Tyger" are spread all throughout the storyline with "tyger" replaced by "spider".
- The Punisher MAX: The one-shot "The Tyger" depicts the child Frank Castle studying Blake's poem at school, with strong comparisons between Blake's terrifying tiger and the person Frank will grow up to be.
- In the 1831 AD one-shot of The Wicked + The Divine, one of the early-nineteenth-century Pantheon members who is already dead when the issue starts, the Angel of Soho, is clearly analogous to Blake.
- Marriage of Heaven and Hell gets its title from Blake’s book of the same name, and it has the angel protagonist Makoto Fujiwara develop friendships with the devils of the Occult Research Club.
- 24-Hour Party People: When Tony Wilson is talking about the saga of his failed club, the Hacienda, he quotes from "The Marriage of Heaven and Hell" - "The road of excess leads to the palace of wisdom."
- Blade Runner: When Roy confronts Chew in Chew's shop, he says "Fiery the angels fell; deep thunder rolled around their shores; burning with the fires of Orc." This is a misquotation from Blake's America: A Prophecy. The original goes "Fiery the angels rose, and as they rose deep thunder roll'd. Around their shores: indignant burning with the fires of Orc."
- Bull Durham: When Annie storms into Crash's apartment and accuses him of trying to keep her from sleeping with Nuke, he interrupts her by comment on how excessive her dress is, at which point she responds, "'The road to excess leads to the palace of wisdom.' - William Blake."Crash: Wh — William Blake?
Annie: William Blake.
Crash: Wi-William Blake?!
Annie: William Blake!
Crash: What do you mean, William Blake?
Annie: I MEAN, WILLIAM BLAKE! - One of the protagonists of Dead Man is a Blake fan, and quotes him extensively. The other is named William Blake, but otherwise has no connection to the poet.
- In the Bedroom: A running gag at the poker games Matt plays at is he always takes his time deciding what to bet, which leads one of his friends to start quoting poetry; one of those times, it's from "Auguries of Innocence".
- Liberal Arts: Jesse gives Zibby a copy of Songs of Innocence and of Experience (along with Dracula) in the end.
- Cold Days: Thomas's "The path of excess leads to the palace of wisdom" paraphrases William Blake.
- Bill "Taleswapper" Blake is a major supporting character in the alternate history series The Tales of Alvin Maker.
- William Blake is a supporting character in the Doctor Who New Adventures novel The Pit.
- There are numerous references to Blake's works in Rollerskater, including a weapon meant to be the "Sword" mentioned in Jerusalem, and a character named "Blake".
- The Tyger provides the epigraphs to each section of 1632.
- The Stars My Destination is also known as Tyger! Tyger!, its title taken from The Tyger. The poem is also referenced in the epigraph to Part One of the book.
- Revenge quotes his famous Infinite/Perception statement in the episode "Perception".
- The Mentalist: The Big Bad, Red John, is a big fan of Blake's poems, as well as his close accomplices, The Blake Association.
- Bruce Dickinson's album The Chemical Wedding derives inspiration from Blake's paintings and poetry, using Blake's painting The Ghost of a Flea as the album's artwork.
- Moby has a song titled "The Poison Tree".
- Ulver set all of The Marriage of Heaven and Hell to music for their fourth album, resulting in Epic Rocking to the extreme.
- Yu-Gi-Oh! Abyss: White Zoa of Dogmatika and The Bystial Alba Los, the boss monsters of their respective archetypes, are named after the characters from Blake's poetry. White Zoa is named after the Zoas and Alba Los is named after Los. One of Albaz's dragon forms is even named after Albion, and he has a sigil representing the four Zoas on his outfit.
- The premier trailer for Death Stranding opened with a quote from Auguries of Innocence.To see a world in a grain of sand
And a Heaven in a wild flower
Hold Infinity in the palm of your hand
And Eternity in an hour - Devil May Cry 5 is a full-on homage to the works of William Blake, as they play a major central theme in the context of both the story and the game's development.
- Playable character V, in particular, is notable for speaking almost entirely in William Blake poetry. In his reveal trailer, he quotes a line from The Marriage of Heaven and Hell.
'He who desires but act not breeds pestilence'... so it is written.- The villain of the game, Urizen, is also named after a major character in William Blake's works. And he very fittingly acts a lot like the character he is named after.
- Shin Megami Tensei III: Nocturne has a boss fight against Albion and the Zoas in the Amala Temple.
Webcomics
- The title of Tiger, Tiger is a reference to Blake's poem The Tyger.
- This
Housepets! strip, in a double reference to Calvin and Hobbes, has Peanut monologue a spoof of The Tyger over a sleeping Grape.
- The 42nd episode of Batman: The Animated Series is titled "Tyger Tyger", with Batman even quoting the source in the end.
- Neo Yokio makes several references to the works of Blake. The national anthem of the eponymous city state is the hymn Jerusalem with the word "England" changed to "Neo". In a later episode a character enters the Tiger Bar by giving the password "fearful symmetry" from The Tyger.
