Pixar film
- Ralph Breaks the Internet: Carl's house can be seen in Oh My Disney.
- Toy Story 4: There is a painting of Muntz playing cards with the dogs in the antique shop and in certain posters.
- In one FoxTrot Jason says he went to see the movie and it inspired him. Cue Paige sitting on a lawnchair with a bunch of balloons tied to her.
- Off the Mark: Carl appears in this strip.
- Mutts: This strip has a bird encountering a house with a bunch of balloons tied to it.
- LEGO The Incredibles: Russel appears as an unlockable character, unlocked by building Carl's House in the Municiberg Financial District. Russel can summon Kevin, track clues, travel through crawl vents, and light campfires.
- A filler arc of Sluggy Freelance has Torg go to see an Avatar parody, and one of the previews is for a horror movie version of Up told from the perspective of the balloons.
- Bum Reviews: Chester A. Bum has reviewed the film.
- The Nostalgia Critic:
- In his review of Steel, the Critic comments that the main character's house looks very much like the one from Up.
- In his review of Stuart Little, Carl's house is shown when the Critic mentions that Mr. and Mrs. Little take Stuart to his new house "as featured in several Disney properties".
- In his review of Osmosis Jones, after counting seven cop movie cliches in three minutes, the Critic says the film's premise is as original as a computer-generated direct-to-DVD movie as he shows the posters for Up and What's Up Balloon to the Rescue! side-by-side.
- Really Freakin' Clever: In "64 Things WRONG With Majora's Mask", during the part where the Moon's Tear lands in Termina, Joshua guesses that the Moon was watching the first 10 minutes of the movie.
- SuperMarioLogan: In "Jeffy Goes to Disney World!", Mario buys Jeffy some Up-themed Mickey Mouse ears at the gift shop.
- Todd in the Shadows: Todd decides about ten seconds in that "I Took a Pill in Ibiza" by Mike Posner is the saddest song he's ever heard in his life. "Christ, the beginning of Up didn't make me this depressed!"
- MAD:
- The sketch "S'UP" has Carl meeting the cast of Jersey Shore.
- Carl also makes cameos in the sketches "2012 Dalmatians" and "The Buzz Identity".
- Episode 3 also features an advertisement for a product tie-in based on the film simply called "UP".
- Robot Chicken:
- A sketch from "Saving Private Gigli" features Carl attempting to fly to Paradise Falls, only for the balloons carrying his house to break away, causing it to fall on some construction workers, killing them and getting Carl arrested as a result.
Carl: I won't last ten days in prison.- A sketch from "Musha Shakhtyorov in: Honeyboogers" has Gooey Louie watch the film on an airplane. Five minutes into the film, Louie tears up and wipes his nose on the tie of the germaphobic passenger next to him, much to the latter's ire.
- A sketch from "Callie Greenhouse in: Fun. Sad. Epic. Tragic" involves Carl winding up in the Land of Oz when his house lands on Dorothy and Glinda.
- The Simpsons:
- At one point in Coming to Homerica, Carl's house can be seen the background.
- One episode features an Itchy and Scratchy cartoon that spoofs the film called "P.U."
British film series
- The 2016 YA novel You Look Different in Real Life is about five youngsters who were filmed for a documentary when they were all six, with follow-ups chronicling how their lives have changed during five-year intervals. This is comparable to the premise of the Up films.