Raising Hope: In "Yo Zappa Do (Part 2)', Virginia says that child stars "could star in a Spielberg movie and still end up playing the nutty mom on some sitcom". This is an Actor Allusion for Martha Plimpton, who did appear in the film as a teenager.
pop'n music 10 includes a remix of the track "The Goonies R Good Enough", complete with a cartoony rendition of Mikey as your opponent, since Konami created the film's video game adaptation for the Famicom. Beating the song makes him replicate his death animation.
World of Warcraft: In the "Vanilla"/Classic game, the layout of the gigantic cavern hiding a ship at the end of the Deadmines dungeon (in which pirates hide) is very similar to the one containing One-Eyed Willy's ship.
American Dad!: Ian "May the Best Stan Win", Steve and and his friends try to remake Mannequin, and Roger agrees to direct it only if they make it Goonies remake.
Roger: Look at you four! Fat, nerdy, smart-mouthed, Asian. You guys are the Goonies!
Bob's Burgers: The episode "The Belchies" is an homage to this film, complete with Cyndi Lauper singing a parody of "Goonies are Good Enough".
In "Breaking Out is Hard to Do", the Griffins hide from the cops in a sewer, Peter asks the Goonies for directions. He then makes Chunk do the "truffle shuffle".
In "Hell Comes to Quahog", one of Meg's tasks while working at Superstore USA is feeding Sloth in the basement.
In "Stew-Roids", Peter takes a look at Connie talking with two of her friends, takes out an old coin where they fit into the holes from his view, and says "That's what One-Eyed Willy buried his gold!".
Inside Job (2021): In "The Brettfast Club", Reagan reveals to Brett that she never saw The Goonies. At the end, the two watch it together on Blu-ray and have a rather uneasy experience.
Reagan: So, is their disabled brother just straight-up chained to a wall?
Brett: Huh. Wow, yeah. That's... that hits different today.
New Looney Tunes: The two-part episode "The Loonies" is a parody of the film.
