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Live-Action TV
  • In episode 109 of Muppets Tonight, Kermit the Frog fills in for a performance by Giganticus by performing "Once in a Lifetime" as a parody of Stop Making Sense, reenacting scenes from the "Once in a Lifetime" video in his own version of David Byrne's big suit.

Music

  • The music video for "Weird Al" Yankovic's "UHF" includes a parody of the "Once in a Lifetime" music video, with Al in David Byrne's place.
  • The music video for Yellow Magic Orchestra's "Taiso" is in part an extended parody of the "Once in a Lifetime" music video.
  • Footage from the "Once in a Lifetime" music video appears in that for "Winning the Most" by Red Vox.

Video Games

  • In Animal Crossing (2001), one of the phrases a villager with the "Normal" personality type can say upon being awoken from a nap is "...What in the...? This is not my beautiful house, [catchphrase]! How did I get here?"
  • Hearthstone: The Just a Hallucination tavern brawl has "These aren't my beautiful cards, this is not my beautiful deck!" in its description.

Web Animation

  • In ENA, the title character frequently reenacts David Byrne's motions from the music video, most prominently the duplicate dances with the Merchant and the Shepherd in "Temptation Stairway" when exchanging a turrón.

Webcomics

  • Housepets!
    • The title to this comic, "This Is Not My Beautiful House," quotes a snippet of lyrics from the Talking Heads song "Once in a Lifetime." Its Alt Text also quotes the song's lyrics: "Time isn't holding us, time doesn't hold you back."
    • A second example from "Once in a Lifetime" occurs in the dialogue of this comic when Maxwell says, "HOW DID I GET HERE?"

Western Animation

  • In The Grim Adventures of Billy & Mandy, the episode "Duck!" opens with Grim dreaming about living in an idyllic Underworld-themed sitcom, only to realize that "this isn't my beautiful house! This isn't my beautiful wife!" Upon waking up, Billy repeats "same as it ever was" several times before Grim cuts him off.
  • The Simpsons: The song plays in the episode "Days of Future Future", over a montage of Homer's clones dying.

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