- Chip 'n Dale: Rescue Rangers (2022): While Chip walks through the L.A. streets complaining about cash-grab reboots, he sees a billboard for Mr. Doubtfire starring Meryl Streep.
Live-Action TV
- Married... with Children:
- In "Business Still Sucks", after Jefferson is ousted as pretending to be a breastfeeding mother during a sit-in protest at Gary's, Al asks if "there's any more Mrs. Doubtfires here", only to accidentally yank the hair of a real female and mother, Dot, who proceeds to knock Al across the shoe store.
- In another episode, Al and Peggy go to rent a dirty movie and select "Mrs. Assfire".
Web Original
- Sam & Mickey: In "The Assistant" during the Terrible Interviewees Montage, one woman is strict, taciturn and repeatedly says all the things that she doesn't do and another woman can only say "I am job".
Western Animation
- The Critic:
- One episode had Franklin dressed as Mrs. Doubtfire to get a job as a nanny for the children, says he'll lose his false teeth and set his bosoms on fire. When Eleanor questions why he's dressed that way and he bemoans how he's only doing it to be with the children, she points out how he can be with them anytime, only for him to reply, "Who wants to do that?"
- In "Siskel and Ebert and Jay and Alice", when Ebert is interviewing a replacement for Siskel, he shows him a sequel featuring Arnold Schwarzenegger as Mrs. Doubtfire, when his bosoms explode for no reason, and he proclaims "They'll be back!" After the horrified man's face melts off, Ebert continues to show him another bad film.
- Xandir of Drawn Together meets (and falls in love with) a genie who is a pastiche of Robin's Aladdin role, and his third impersonation is "a crossdressing nanny".
- The Simpsons: One episode has the Simpsons trying to interview for a nanny, only for Homer to keep scaring them away by assuming they're all men in drag, even referencing the film by name.
