While in canon he planned on mutating the Turtles into snake-monsters so that they would kill Splinter for him, here the Shredder prepared the snake-mutagen vat to mutate Yoshi into "the mindless and treacherous serpent he is on the inside."
Tang Shen is mutated into a snake instead of Miwa.
While a half-feral Karai fled at the end of "Vengeance is Mine", here Tang Shen does not, the Hamatos managing to take her home despite her fragile mental state.
In Spite of a Nail: Shredder still creates the vat of snake-based mutagen despite not wanting to mutate Yoshi's sons this time. Instead it's meant to mutate Yoshi into what he sees him as.
Medusa: The text openly compares Tang Shen's mutated form to the Greek gorgon.
Never My Fault: Much like in canon, Shredder blames Yoshi for Tang Shen being mutated, never mind the fact that it was his vat of mutagen and his method of bait was hanging their daughter precariously over it.
