Eastern European terrorists prepare to hijack Quagmire's plane carrying him and his friends after a trip to San Francisco.
This episode contains examples of:
- Does This Remind You of Anything?: When the plane is flying into the canyon and deploys extinguishant.
- Episode on a Plane: This episode centers around Peter, Cleveland, and Joe traveling in Quagmire's plane when it gets hijacked by terrorists.
- Shout-Out:
- This episode's title is a reference to Passenger 57.
- A cutaway gag references the film Inside Out, with Peter as "Poo".
- Take That!: The very last line of the episode:Peter: In case we didn't say, this was Spirit Airlines.
- Universal-Adaptor Cast: During Peter's remake of Inside Out, all of the Griffins (except Peter, who is "Poo" instead of Fear) are given a role that matches their personalities.
- Chris is Joy; he's a happy-go-lucky Kindhearted Simpleton.
- Meg is Sadness; she's a frequent Butt-Monkey who is shown to be depressed as a result of the abuse heaped upon her.
- Stewie is Anger; he has a short temper, and he was an Ax-Crazy Enfant Terrible in the earlier seasons (with the occasional bout of such behavior in modern seasons).
- Lois is Disgust; she's the Only Sane Woman who is often disgusted with the actions of those around her, particularly her husband's.
