Papa Smurf recounts a time before Empath's final return from Psychelia where he had Tapper run a "Smurf No To Smurfnip" campaign to keep his little Smurfs drug-free... only for Gargamel to use smurfnip-laced smurfberries as a weapon against them. A few unaffected Smurfs must find a way to combat the effects of smurfnip and help free the captured Smurfs.
This story provides the following examples of:
- Cigarette of Anxiety: Grouchy tries to resist the temptation of smoking a smurfnip cigarette, but ends up succumbing to it and almost being arrested by Brainy and Hefty posing as police officers.
- Closest Thing We Got: When the village is affected by the smurfnip-laced smurfberries, Tracker and Sickly must work together to restore the Smurfs to normal and mix up the antidote to smurfnip intoxication. Sickly says that neither he nor Tracker are alchemists like Papa Smurf, but Tracker says that he himself knows the difference between various types of plants, so he's the closest thing the village has to an apothecary.
- Drugs Are Bad: Papa Smurf has Tapper head a campaign to show that smurfnip is supposedly bad for the other Smurfs. The true Aesop of the story is more treating recreational drug users like criminals is bad, as Hefty and Brainy go around throughout the story as police officers that bust Smurfs for even having a smurfnip joint in their possession.
- Duel to the Death: Minus the "death" part, Hefty and Duncan McSmurf duel with each other while they are intoxicated with smurfnip — Hefty using his police baton and Duncan using a sword — in order to get the other person to drop his weapon. When Tracker brings them to their senses, neither of them remember why they were even dueling with each other.
- Everybody Must Get Stoned: The Smurfs eating smurfnip-laced smurfberries, with one of the Smurfs actually singing a Smurf version of a Bob Dylan song.
- Fantastic Drug: Smurfnip, which is used as a stand-in for pot with the associated Marijuana Is LSD trope. A telltale way to know that someone is stoned on smurfnip is that the whites of their eyes turn green.
- Get Out!: Culinary Smurf to Tracker and Sickly, when they were investigating the kitchen to find out what ingredients were used in the smurfberry cookies that made the Smurfs act so silly.
- Goggles Do Something Unusual: Handy creates a pair of glasses called the Hallucinator, which is supposed to simulate the visual effects of being under the influence of smurfnip (including a rainbow-colored haze). They were originally created as a tool for Smurfs to say no to smurfnip. By the end of the story, Vanity wears them because he likes looking at himself while wearing them.
- Government Drug Enforcement: Empath mentions that all Psyches in Psychelia are required to take a drug called psychelium, which inhibits their ability to express emotions.
- Heel–Face Revolving Door: Gargamel almost has a complete Heel–Face Turn when he is under the effects of smurfnip, promising never to go after the Smurfs...until a hallucination of his mother appears to berate him for being a failure, making him change his mind and remain being the Smurfs' enemy.
- High on Catnip: Gargamel sees Azrael staggering to the door baked on catnip.
- Marijuana Is LSD: Smurfnip acts like this with its users. One of Smurfette's hallucinations while under the influence is seeing Vexy and Hackus from The Smurfs 2. Also in the story, Handy created a special pair of glasses that simulate the visual effects of being under the influence of smurfnip.
- Mushroom Samba: The Smurfs have various types of hallucinations when they end up eating smurfberry cookies that are laced with smurfnip. Gargamel and Azrael themselves become similarly affected when they breathe in the fumes of concentrated smurfnip.
- No Time to Explain: Tracker says this after he cures Hefty and Duncan McSmurf of smurfnip intoxication right in the middle of a duel with each other, saying that they need to find the Smurfs Papa Smurf sent into the forest to find more smurfnip before Gargamel finds them. Hefty and Duncan pretty much figure out that it was Gargamel behind the smurfnip-tainted smurfberries they had eaten.
- Pun-Based Title: The title of the story is based on the infamous anti-drug film Reefer Madness.
- Suddenly Sober: Papa Smurf has a remedy that makes Smurfs suddenly sober from the effects of smurfnip.
- Take That!: This story was a commentary on the American War on Drugs kind of drug prohibition and how costly and ineffective it is to get people to stop using drugs.
- Tampering with Food and Drink: Gargamel sprays a concentrated amount of smurfnip mixed in with an appetite attractant on the smurfberries so that the Smurfs would eat them and get high.
- This Is Gonna Suck: Slouchy at the beginning of the story when he and the other Smurflings are caught with smurfnip and Papa Smurf punishes them by having them clean the outhouses:"Better bring a clothespin, because this job's going to stink."
- Title Drop: Near the end, Empath says:"As long as we don't have to face another case of smurfnip madness, this smurf doesn't see the problem of letting the Smurfs do what they want that doesn't harm anybody else."
