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Loki: I thought you said you knew how to fly this thing!
Thor: I said "How hard could it be?"!

The Doctor: This is one of the safest planets I know, there is never anything dangerous here!
(ground rumbles)
The Doctor: There are some sentences I should just keep away from.

The Doctor: (having just built a make-shift TARDIS out of broken TARDIS-remains) Right, perfect, look at that, what could possibly go wrong?
(a piece falls off)
The Doctor: That's fine, that always happens.

Geek Scientist: Look, we have medics and guards standing by just in case. And this is one of our strongest containment rooms. Everything is under control.
Joel: You do realize that the scientist say that in every horror movie, just before things go horribly wrong.
Geek Scientist: This isn't a cheesy B-Movie, Joel. Relax! What could go wrong?
Joel: Are you trying to get us all killed?

Isabela: I have a bad feeling about this.
Varric: "I have a bad feeling about this"? That's up there with "What could possibly go wrong?"!

Wilma: So you see, Fred doesn't know he's wearing the wrong glasses, and everything is out of focus!
Barney: Yeah, but there's nothing to worry about, Wilma. What could happen to him?
Betty: That's right, Wilma. After all, he's at the circus. How could he possibly get into trouble?
Wilma: Remember? We're talking about Fred Flintstone.
Betty and Barney: He'll find a way!
The Flintstones, Fred's Monkeyshines

Helicopter Pilot: Welcome to Itchy and Scratchyland, where nothing can possib-lie go wrong. Uh, possibLY go wrong. That's the first thing that's ever gone wrong....
The Simpsons, Itchy & Scratchy Land

Dr. Brown: I just don't think we're ready to launch the system. We still have to run tests on it.
Doctor Whooves: I know, but Cranky says we need it running as soon as possible. Besides, what could go wrong?
My Little Portal, Episode 1

"What could possibly happen, going to an insane man who hates me and owns a bunch of swords?"

"Eight years involved with the nuclear industry have taught me that when nothing can possibly go wrong and every avenue has been covered, then is the time to buy a house on the next continent."

"The major difference between a thing that might go wrong and a thing that cannot possibly go wrong is that when a thing that cannot possibly go wrong goes wrong it usually turns out to be impossible to get at or repair."

"Well, my reaction, to be honest, was one of absolute dismay. I thought it was a terrible idea. My feeling was that the clone story was best left in the past. Don't get me wrong, I enjoyed those original stories and found the ending very touching and poignant, and I thought the Jackal was a hoot, but I felt that dredging up all that stuff again was a mistake. Mark calmly replied, "Give it a chance. You don't know all the plans we have lined up, and I think once you approach it with an open mind, you'll see that it can work."
Editor/Writer Glenn Greenberg on The Clone Saga

Bubsy: What could possibly go wrong?
Jon: I don't know, you're pretty safe with a Chapter One called 'Cheese Wheels of Doom', so I'm willing to wager that EVERYTHING COULD GO WRONG.
JonTron, Bubsy Collection

What could possibly go wrong? (Here's a hint: everything)
The Cutting Room Floor when describing Five Nights at Freddy's 3

News Anchor: In our top story, the president of planet Midway, against the better judgement of the experts, has agreed to use Doctor Muto's new energy device in a desperate attempt to end the power crisis caused by Burnital Industries. The eccentric madman- *cough*, scientist, assured the president that this new device could power a dozen planets! Muto fought back reporters saying:
President: To the end of the energy crisis! Five... four... three... two... one! *Turns machine on* Is that it?
BOOM!
Dr. Muto, opening cutscene

"I cannot imagine any condition which would cause a ship to founder. I cannot conceive of any vital disaster happening to this vessel. Modern ship building has gone beyond that."
Captain Edward J. Smith while commanding the RMS Adriatic, four years before his ill-fated command of the RMS Titanic

"The game everyone keeps pointing me to is Sonic the Hedgehog (or Sonic '06 as it's known by). I can't imagine it being that bad because it's Xbox 360. It's only slightly over ten years old. I mean, how bad could this pos—it's gonna fucking suck, isn't it?"

Calvin: Look, stop being such a baby and help me push the car into the driveway. We'll move it 10 feet. What could possibly go wrong?!
Hobbes: Whenever you ask that, my tail gets all bushy.

Morpheus: You worry too much, Lucien. I've noticed this before. After all, this is completely straightforward. What could possibly go wrong?
Lucien: Whatever you say, my lord. Whatever you say.

"It says here that scientists are planning to bring back long-extinct creatures through genetic engineering. Isn't that dangerous?"
"Ha! What could possibly go wrong? What exactly is a Shoggoth anyway?"

Riku: Wait, so you want to interview me, so you can write a fake tabloid article about Sora and Kairi, for a creative writing assignment?
Ai: Yes! You talking about Sora-kun and Kairi-chan potentially getting married by year’s end, as well as Kairi-chan staying home sick today and Sora-kun swooping in to nurse her to health, I can absolutely see a tabloid article in the making. I could totally swing it as a pregnancy scare.
Riku: Please don't. What if your fake article leaks?
Ai: Aw, don't be so serious, Miyano-senpai! It's just a bogus class assignment. I'll even clear it with Kairi-chan before I submit it for grading. What could possibly go wrong?
Akira: Well that's a giant flag of doom and despair. If anyone asks, Ryuji and I had nothing to do with this.

You're already huge, you figure. Nothing else here was bad. In fact, it was all amazingly delicious, as your jiggling bulk will attest. So what's the harm in ignoring a few "DO NOT TOUCH" signs?
Weeb's Wonka Game

Knuckles: This seems awfully sus, Sonic, I don't know about this.
Sonic: Oh, come on, Knux! What's the worst that can happen?
Luigi: Oh no...

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