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    Anime and Manga 
Athrun: Kira! You come too! There's no reason why you should remain with the Earth Forces!
Kira: Believe me, I don't want to fight you. But aboard that ship are people I wanna protect. My friends are aboard that ship!
Athrun: [Beat] Then I've got no choice. The next time we battle, I will personally defeat you!
Kira: The same goes for me!

    Comic Books 
"We were friends once, Luthor... long ago. For a time, I hoped we could be friends again – Maybe we will be, someday – but in the meantime, we are enemies, because you chose lawlessness, and I chose law!"

"I gave you fair warning, Superman — a good deal more warning than I would have given anyone else! I did so because you were my friend — but the bonds of friendship can only be stretched so far before they break!"

Supergirl: Lena... I'm still me! I'm your best friend!
Lena: Not anymore... Not now that I know the truth! You're my enemy now. I have no choice but to destroy you!

"Someone playing music a mile away. I know that song! It's Siobhan's! At least I still have your music... Nothing's the same without you. Here I am trying to fit in on this planet, and I've lost the first friend I ever [made.]"
Kara, Crucible

"I became aware of... experiments... your father was pursuing, Kara. Experiments that would surely incur the wrath of the Council should they learn about them. I warned Zor-El that his work could endanger the freedom of all scientists on Krypton to conduct their research, should the Council decide to take action. He took offense. And we have not spoken since."

"Sorry about this, Superman! We were friends once— but not any more!"

"We're NOT friends, Thara. Not anymore. Not ever again. You let my father die. You stay away from me. I'm done with you. Forever."

"Now I know the secret you've been keeping from me— that Lex Luthor, one of the world's most monstrous criminals... is my brother! We were friends... I trusted you... But you betrayed me! Now get out of my sight, Supergirl... GET OUT!"

    Fan Works 
Lilly: I'm Lilly Satou, Hanako's... we knew each other in high school.
Hanako: [narrating]] The way she sidesteps our near inseparable friendship hurts, but I suppose I should've expected it. Neither of us is sure how this is going to play out at this point.

"I... I... thoughts not mine... Ritsuko my... friend? I... I didn’t want to believe... fed up with her... fed up... had to hit that bitch. Had to hit that bitch! Feel her flesh crumple beneath my fist... yeah, just hit her, just make her shut up. Shut up! Shut up!"
Misato, Thousand Shinji

"I swear she's done some awful things in her life, but I will never forgive her for that."
Misato declaring her friendship with Ritsuko is over, Neon Genesis Evangelion: Genocide

After all, if Shinji was right, Ritsuko, good ole Rits herself was fully aware of the ultimate goals of the Evangelion project.
Hell, she was up to her ever so pretty neck in it.
Meaning he had no choice but to treat her as an enemy. Someone he had known for close to a decade and he thought he knew well…and thought of as a friend.
It was no easy shift to make in ones thinking, even for him.

"I compared you to my best friend, not to the monster she became."

Rainbow Dash: Gilda! Tell me, why are you doing this? We used to be friends!
Gilda: That’s right, Dash! We used to be! But you chose those ponies instead of me!

"Superboy stomps back in, and he doesn't look pleased. Lex figured either he's going to get hit, or taken to jail, or both. But Blue Boy doesn't do either thing. He said that, since Lex saved his life once, he was going to give him a break and not take him in. He said that squared the debt between them. But he also said that he would never trust him again, that he could never see Lex as a friend again, and, believe it or not, that hurt Lex. Don't ask me or him why, but he said it did hurt."
Nasthalthia Luthor, Kara of Rokyn

Alya: "I can't be friends with someone who won't apologize and can't even see what she did."
Marinette: "I can't be friends with someone like that either. So I guess we're not friends anymore."

Dru-Zod: Be reasonable Jor. The last thing I want is for us to become enemies El. Join me and save Krypton.
Jor-El: You've have abandoned the principles that bound us together. You've taken up the sword against your own people. I will honor the memory of the man you once were. Not the monster you've become.
Dru-Zod: [coldly, to his men] Take him away.

"I thought of you as an ally, you know. There were so many times I wanted to reveal everything to you. It is my own folly that has lead us to this point."
Byleth grit her teeth, yanking her sword away from their lock. She swung the tip forward in an arc, using the momentum to knock Edelgard off balance. "Shut up! I don't want to hear anything more from you! I trusted you. Everyone trusted you!"

Scratch: Come on, Molly. You confronted the entire Ghost Council and even destroyed The Chairman, all because they didn’t believe a human and a ghost could be friends. So why are you letting this little self-righteous Hypocrite get to you like this?
Molly: She was my friend.

    Film — Animation 
"We used to be best buddies,
And now we're not,
I wish you would tell me why?"
Anna, Frozen

Copper: It's great to see you, Tod. But you know, you... you shouldn't be over here. You're... You're gonna get us both in a lot of trouble.
Tod: Hey, look, I... I just wanted to see ya. We're... We're still friends, aren't we?
Copper: Tod... Those days are over. I-I'm a huntin' dog now.

"You who I called brother, how could you have come to hate me so?"
King Rameses II, The Prince of Egypt

Nidhiki: This time, your farewell will be forever, brother.
Lhikan: You lost the right to call me brother long ago!

    Film — Live-Action 
"I was your brother, your blood, your friend. Who betrayed who? When are you gonna stop being a goddamn slave and grow up? ...I'm your family—I'm the only family you ever had!"
Rico, Judge Dredd

Anakin Skywalker/Darth Vader: I HATE YOU!
Obi-Wan Kenobi: You were my brother, Anakin... I loved you!

Megatron: We were brothers once!
Optimus Prime: Once.

Gianna: There was a time not so long ago in which I considered us as friends.
John: I still do.
Gianna: Yet here you are. [in Italian] Death's very emissary.

"I was your only friend. You had one friend."
Eduardo Sauverin, The Social Network

    Live-Action TV 
Gunn: What happened to you, man?
Wesley: I had my throat cut and all my friends abandoned me.

The Master: I had estates. Do you remember my father's land back home? Pastures of red grass, stretching far across the slopes of Mount Perdition. We used to run across those fields all day, calling up at the sky. Look at us now.
The Doctor: All that eloquence. But how many people have you killed?

Aughra: Are you proud? To build a machine that will be the death of Aughra?
The Scientist: Not as proud as Mother Aughra throwing her life away in a desperate bid for redemption.
Aughra: It did not have to end this way between us. We were friends once.
The Scientist: [hesitates] Another world. Another time.

Kara: I recognize that I made a mistake in hiding my identity from you for so long, but the past is the past, and I can't change it. Forgive me or not, that's your choice, just like it's your choice to work with Lex. I'm done blaming myself for your bad decisions.
Lena: Then why are you here?
Kara: To tell you that from now on, you're accountable for your own actions. If you decide to forgive me, I will be there for you. But if you continue to work with Lex, if you go through with whatever it is the two of you are planning, I will do everything in my power to stop you, just like I would any other villain.
Supergirl (2015), "It's a Super Life"

    Literature 
Nico: I was your best...friend, and the one whose fiancée you killed in front of me.
Arthur: Nico...You look like garbage, old friend.

Sometimes Konyek would meet his cousin Parmet herding the cattle. Formerly they had gone out together, and been glad of one another's company, for they were like brothers. They lived in the same manyatta, and the mother of one was a mother to the other, so that every child had many mothers and fathers, and many grandparents also. But lately, Parmet had changed. He had grown loud and boastful, and he avoided Konyek's eye because he was jealous of him. He saw that Konyek was the favourite of their grandfather Ol-Poruo, who was famous throughout the land for his wisdom and for his bravery. He saw, too, that the girls favoured Konyek with their glances, and the boys listened to his words. But Parmet was stronger and older, and he competed with his cousin by a show of words, and a display of strength, so that sometimes the others were afraid of him.

    Music 

    Tabletop Games 
No foe is more hated than the former friend.

    Video Games 
"Aw. Just thinking back to the old days when we were friends. Good old friends. Not enemies. And I'd say something like 'come back', and you'd be like 'no problem!' And you'd come back. What happened to those days?"
Wheatley, Portal 2

"I never killed a man, let alone a mate. But this is what things come to. I don't know if killing Mr. Ryan will stop the war, but I know it won't stop while that man breathes. I love Mr. Ryan. But I love Rapture. If I have to kill one to save the other, so be it."
Bill McDonagh, BioShock

Maester Wen Kinoc: Your sentence has been decided.
Sir Auron: Sentence? Don't you mean execution?
Kinoc: Really, now, what person would execute a dear friend?
Auron: You would.

James Vega: You know the Commander?
Ashley / Kaidan: I used to.

Commander Bailey: What the hell pissed him off?
Shepard: I hoped it wouldn't come to this. We didn't see eye to eye.
Commander Bailey: No kidding.
Shepard: He was a friend once.
Mass Effect 3, Paragon reaction to Wrex's death

"I gave you all I had. I did."

Shovel Knight: You've forgotten our oath! What happened to the proud warrior I knew?
Polar Knight: Hmph! No more words. The bitter cold will claim you.

Niko: Dwayne, I dealt with Playboy. You should know that he asked me to end you first. He was going to pay me a lot of money to do it.
Dwayne: Shit, man. He was a good kid back in the day. Always hungry, though, always wanted more. Maybe I shoulda seen it then. Kept a closer eye on him.
Niko: You can't predict what people will become.

Shingen: I once had a very dear friend. He was too serious, stubborn as hell, and the kindest, gentlest man I'd ever known. In many ways we were opposites, but we got along great. We drank late into the night, never running out of things to talk about.
MC: What happened to your friend?
Shingen: A battle. A cruel one. He lost almost everyone he cared about and came out of those fires a vengeful demon. I couldn't reach him. He broke off our friendship. And we haven't talked since.

Superman: Fighting on the same side, it felt like old times. But I guess we both knew it would end this way.
Batman: Do you remember that night? When you told me Lois was pregnant?
Superman: You knew. Even before I said anything.
Batman: That was a good memory.
Superman: From another lifetime.
Batman: I miss the people we were then.
Superman: Me too.

Superman: Why are you on my Earth?
Green Arrow: On my Earth, we're friends.
Superman: Here, we're not.

Batman: We were friends once, Clark.
Superman: It's the only reason you're still alive.
Batman: Thought it was 'cause I beat you.

Superman: You're leaving Earth...now.
Raiden: We were allies on Apokolips, Superman.
Superman: Here, we're not.

Wonder Woman: Another Impostor threatens me?
Green Arrow: On my Earth, we're friends.
Wonder Woman: Prove it.

Green Lantern: We were friends, Clark.
Superman: Not anymore.

Dimitri: Know that I will tear your heads from your shoulders. The dead must have their tribute.
Claude: As big class reunions go...this one's gotta be the worst in history.
Edelgard: Years ago, we fought here as classmates...but not today.
— "Blood of the Eagle and Lion", Fire Emblem: Three Houses

"Before the Great Turf War, there were amicable relations between the Inklings and the Octarians. They couldn't have dreamed that rising sea levels would force them to battle fiercely over the remaining territory."
Sunken Scroll 16, Splatoon

Boomerang Kuwanger: If you've made it all the way up here, you must not be an ordinary B-class hunter.
X: Kuwanger... I don't want to fight an old friend like you.
Boomerang Kuwanger: You don't want to fight? Well, isn't this interesting? You're a Maverick Hunter... And Maverick Hunters are Reploids designed for fighting.
X: So I'll have to fight you no matter what, huh?
Boomerang Kuwanger: Of course! A chance for a fight this fun doesn't come along every day!

Sting Chameleon: Whoo hoo! It's Vile... I used to have nothing but respect for you, you know.
Vile: In that case, get out of my way and let me pass.
Sting Chameleon: Nyah hah ha! I don't think so! We're going to have to fight!
Vile: If you say so... I won't let you or Sigma stand in my way!

"The rise of the Galactic Empire offered X1 power beyond his wildest dreams. But Order 66 and the Jedi Purge soon turned brother against brother. After the death of Master Ferroda, I could serve the Empire no longer. It was on Dantooine that I would encounter Falon Grey, one of the last of the Jedi, and learn the true identity of my genetic father. I would also be reunited with X1, this time on opposite sides of the battle lines."

"He used to be my partner... I've gotta take him down myself."
Keith Martin on Robert Baxter's betrayal, Time Crisis 5

Neia: Why do you pray for her?
Ahlim: If it hadn't been for the war, we could have all stayed friends, almost as close as sisters. All of this conflict changed Mia. But now she's gone to a place where war doesn't matter anymore. Everything between us has gone back to that way it used to be. That's all.

Atreus: I thought we were his family too...
Kratos: We were...

    Webcomics 
Durkon: Thar be no compromise! Thar be no parley an' thar be no reasonable discussions! Yer a frickin' vampire, Malack! Yer a danger ta everyone livin' on this continent! An' e'en if'n I ignored tha, ye still cannae be 'llowed ta seize this place!
Malack: ...I see. Then there can only ever be conflict between us now.
Durkon: Aye. 'Fraid so.
[Malack bows his head]
Malack: Then die.

    Western Animation 

Stan: How did things get so messed up between us?
Ford: We used to be like Dipper and Mabel. The world's about to end and they still work together. How do they do it?
Stan: Easy. They're kids. They don't know any better.

Vlad Plasmius: Jack, you have to help me! You wouldn't turn your back on an old friend, would you?
Jack Fenton: An old friend? No. You? Yes!

"White, we used to be close. Don't you remember? When Pink would make us laugh? All those silly things she did for no reason, there was a reason. She wanted us to be happy together. But we weren't, and we're still not. I know my purpose isn't to be happy, but I find it harder and harder to enforce your rules, when they make me miserable. When they make us all miserable."
Blue Diamond, Steven Universe ("Change Your Mind")

Rapunzel: Cass... we're friends. In fact, being Gothel's daughter, that... that makes us closer than friends. It makes us sisters...
Cassandra: Sisters?! My own mother chose you over me! My whole life, I've been cast aside for you! No more!
Rapunzel's Tangled Adventure, "Rapunzel's Return"


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