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Basic Trope: Creatures that are based on silicon instead of carbon.
  • Straight:
    • The Cshorkians are silicon-based.
    • The Ptorkians use ammonia as a solvent.
    • The Aworkians use arsenic instead of phosphorous.
  • Exaggerated: The Yborkian biochemistry violates several laws of chemistry and physics.
  • Downplayed: The Gcorkians have alternative-chirality biomolecules.
  • Justified:
    • Life finds a way, even in environments that are absurdly hostile for carbon-based, water-drinking life.
    • The creatures in question are artificially made and thus something other than carbon as a result.
  • Inverted: Human Aliens
  • Subverted: Aliens arrive, and appear to be carbon-based.
  • Double Subverted: They are revealed to use ammonia as a solvent.
  • Parodied: See Exaggerated.
    • Two Zorgians are relaxing on a beach next to an ocean of molten lava, under 100 bars worth of sulfuric acid, one of them asks if it's possible that carbon-based life using H20 as a solvant could exist, and the other laughs and tells him he watched too many stupid sci-fi movies.
    • There is silicon-based life, and there is also silicon-cringe life.
  • Zig-Zagged: The aliens are silicon-based, but use water as a solvent. However, their DNA contains arsenic instead of phosphorous.
  • Averted: All aliens are carbon-based.
  • Enforced: The writer wants to show how great the diversity of life is in his universe.
  • Lampshaded: "Now I haven't seen that kind of biochemistry before..."
  • Invoked: Humans create life with a variant biochemistry on some distant world For Science!
  • Exploited: A farmer herds animals with specific biochemistries to farm rare materials produced inside them.
  • Defied: The work only visits planets with carbon-based life.
  • Discussed: "Oh look, a new planet found with ammonia-based life!"
  • Conversed: "I wonder if they get drunk on ethamine..."
  • Deconstructed: Silicon-based life is so strange that it can't be recognized as alive by "regular" aliens, and the incredible silicon-based ecosystem on its Death World goes unnoticed by scientists. Even if they do notice, they are so alien to each other that communication is virtually impossible.
  • Implied: The Bporkians explode violently in Earth's air.
  • Played for Laughs: Two humans discuss the possibility of alternate biochemistries. Cue two silicon-based homnids on another planet having the same conversation.
  • Played for Drama: Biochemical discrimination arises at the galactic stage.

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