Season 1
- The first scene in the series mimics the first scene in the comic, with an angry client becoming unruly until Jessica tosses him through the window of her office door.
- Trish's suggestion for a superhero identity for Jessica, which Jessica flatly rejects as absurd, is a reference to Jessica's time as Jewel in the comics, which would really clash with the show's tone. The prototype costume Trish presents to Jessica is the same one she wore as Jewel in the comics, while the mask is a blue version the one she wore as Knightress. It is also the same color as Trish's from the comics.
- In Episode 4, when Audrey threatens Jessica at gunpoint, her response is taken straight from a scene in Alias. Only this time she is actually shot.Jessica: You shoot at me, I will pull the bullet out of my ruined jacket and shove it up your ass with my pinkie finger. And who do you think that's going to hurt more?
- At one point, Jessica recommends a fellow P.I. named Angela Del Toro.
- Most people smoke after sex. Luke Cage? "Sweet Christmas".
- One of Trish's fans says that he misses her red hair. In the comics, she is a natural redhead.
- The colors of the Trish Talk logo reflect the colors of her uniform from the comics.
- At one point Luke has to fight a pack of dogs on his own. When Jessica expresses concern, he assures her that "sharp teeth are his specialty" — a reference to his enemy Cottonmouth, who appears in Luke's own show, but not with the sharp filed teeth.
- Trish admits that she wishes she could be a hero, as she wants a chance to save the world. In the comics, she's the costumed superhero Hellcat.
- In the season finale, Kilgrave says that he wants to force Jessica to love him, and then reject her again and again until it completely destroys her sense of self worth. In the comics, that's what he did to torture her in the first place.
- In the flashback which has Kilgrave meeting Jessica for the first time, he wants to know her superhero name instead of her real name. In the comics, he never wanted to know her superhero name.
- In the final episode, Jessica drags an unconscious Luke Cage into the hospital only to find out he can't be helped because of his unbreakable skin. This resembles a scene from The Pulse after the two are injured in an explosion that destroys their apartment.
- In the season finale, Kilgrave has upgraded his powers to the strength they are in the comics: even looking at him is dangerous. When he screams for everyone to stop what they were doing, his skin turns purple.
- The final shot of the season has Malcolm pick up Jessica's phone to say, "Alias Investigations, how can we help?". In the comics, Malcolm's first few (unwelcome) attempts to help Jessica had him acting as her secretary.
- One of the earlier hints at who Simpson is is how he refers to his war buddies as "my boys", which refers to "our boys" something of a trigger-phrase/MadnessMantra of his much crazier comics counterpart.
- He mentions having played with GI Joes as a child, and in the comics, Nuke is essentially an evil GI Joe: Patroitic, over-the-top, and made of plastic.
- While testing the containment room for Kilgrave, Jessica sarcastically insinuates that Simpson probably got discharged from the military for slaughtering a village. In his intoductory story in the comics, he reigned death down on Hell's Kitchen, and his origin story revealed that he did indeed slaughter a village of innocent Vietnamese.
- Simpson has an American flag lighter, a reference to how Nuke is iconic for the flag tatooed on his face.
- Dr. Kozlov shares the last name as Michael Kozlov from Strange Tales. His first name is Miklos, though.
- When talking to Jessica, Luke muses, "Pops always said, if you don't feel good going to work, you should find new work." Pops later shows up as a character in Luke Cage and is revealed to have followed his own advice.
Season 2
- Jessica meets a speedster called "Whizzer", whose attire choices (yellow jacket and blue details — jeans, a blue packpack) are also references to his costume in the comics.
- He also has a pet mongoose named Emil, a reference to the comics version's origin of mongoose blood giving him his powers.
- To try and get Jessica to access her buried memories about her time at IGH, Trish hires Dr. Maynard Tiboldt, a hypnotherapist she's featured on Trish Talk. Maynard Tibolt is better known as the supervillain Ringmaster in the comics, known for hypnotizing people with a mind-control device concealed in a top hat.
- Detective Eddy Costa may be an original character, but his last name is shared with a Mafia family from the Punisher comics.
- When Trish goes to the hospital, a nurse said she lost two of her nine lives, implying she's a cat. In the comics, she is a superhero by the name of Hellcat.
- She also scratches someone in the face with her nails during a fight; the comics character is frequently shown with clawed gloves.
Season 3
- During the montage in the second episode of Trish trying on costumes, the final one she ends up in is an exact duplicate of the classic Hellcat costume. She looks at herself in the mirror and says "Hell no."
- In the same episode, Trish's internet sleuthing turns up an article about the Bodega Bandit, Spider-Gwen's so-called "arch-enemy."
