If you are initially sympathetic to the defenseless villagers in Dynasty Warriors Empires, after hearing "AAAAAH! HELP! HURRY!" for the eleven thousandth time, you might end up cheering for the enraged tigers trying to devour them.
Your character dying in Contra 4, especially on a hard level. YEAAAAAAAARGH!! YEAAAAAAAARGH!! YEAAAAAAAARGH!! [Game Over]
Zone of the Enders: "Grab the stick, and throw it." Yes, ADA, I know this is a Puzzle Boss to teach me how to grab and toss objects. You don't have to tell me every five seconds. The enemy is incredibly fast and destroys me in two combos if I let her get close, and you're not helpinnnnnggggg.
At most other times: "Begin! GAME. OVER. Begin! GAME. OVER. Begin! Line! GAME. OVER. Begin! GAME. OVER. Begin! Line! Trian—GAME. OVER." Yeah, it's that kind of game.
"Help!" "Help! Help us pleeeease!" "I don't like fire!" "The cannon needs reloading!" "Hey, don't leave me! Why don't you understand?!" Any time you have to help those bloody moles during the 'Dragon City' level in The Legend of Spyro: Dawn of the Dragon. Which is pretty much 50% of the level.
Comic Jumper has Gerda, who chimes in every time you hit 75, 50, and 25 percent health by telling you, along with an insult. Considering the game is Nintendo Hard, you will hear her voice until you understand why Captain Smiley doesn't bother rescuing her.
Turtles in Time: The voice clip played whenever a turtle hurts his feet gets old pretty fast. In particular, playing through the Sewer Surfin' stage with more than one player would result in a chorus of "MY TOES! MY TOES!" if any of you were less than flawless.
Few people like the fight against Million Gunman in No More Heroes 2: Desperate Struggle, largely due to the obnoxious platforming, and it's certainly not made any more bearable by his repetitive, grating voice lines: "I'm not gonna go easy on you just because you're a girl. Come on, show me something special." "You know NOTHING about money! Do you love money like I do? I'm not gonn-" FUCK YOU! "Do you love money like I d-" FUCK YOU! "Do you love mo-" FUCK YOU!
In No More Heroes III Travis has a singular line for building up Tension and that line is "fuckhead". He says it whenever you build up any amount of Tension, and certain attacks like the Death Rain cause him to say it constantly even when he's not physically attacking, making it seem like he has Hollywood Tourette's. Jeane also chimes in for combos: "double kill! Triple kill! (ect)" even if you didn't actually finish off an enemy.
The battle with Iron Lord in The Chronicles of Riddick: Assault on Dark Athena always begins with Margo screaming "Fuck his shit up, Iron Lord!" The autosave is right before this line, rather than, say, right after it.
A great deal of every MechWarrior title's gameplay is based on heat management. If in the frenzy of battle you exceed recommended levels, the computer controlling the Mech attempts to shut it down. What usually follows is frantic tapping on the "override shutdown" key, which will keep the Mech active at the cost of much slower heat dissipation, or possibly destruction if you don't stop shooting. Both exceeding the recommended level and overriding the shutdown procedure have their own loud alarm sounds and a lengthy warning delivered by the computer, and every fight you do in any Mech with energy weapons will see you doing that many times.
In Devil May Cry 4, Sanctus shouts "THE SAVIOR IS COMINGGGGG!" whenever he completely restores his shield. That's the last audio cue you want to hear because he's a Shielded Core Boss who requires you to exert some effort in attempting to hit his barrier in the first place. Having it completely restored just drags the battle further.
Killer7. Hitting the weak spot of the enemy will kill it instantly and your character will say his/her catchphrase. OVER AND OVER AGAIN, EACH TIME. Eventually the mute character might become your favorite.
Speaking of enemies, each time an enemy enters your field of vision or otherwise appears on the map, they will let out this high pitched laugh. Sure they each have a slightly different one, but most of the Heaven Smiles you will encounter in the game are the average Heaven Joe, which are all letting out the same exact"NYAHAHA!" that at one point you will just want to punch out of existence.
All of Carnage's battle lines from Spider-Man (2000). "HERE I COOOOME!~""DIE, DIE, DIIIEEE!!!!!""NICE TRY, HAHAHAHA!!!"
In the video game based on Harry Potter and the Prisoner of Azkaban, your party members will start to complain that "I'm poisoned! I really need some antidote!" once afflicted by that status effect - and will continue to do so, repeatedly, until healed.
Teenage Mutant Ninja Turtles (2003) animated series had a video game released in 2003. Like the original games, such as Turtles in Time, the game consists of one of the four turtles playing across a level, beating up enemies and eventually a boss. Someone thought it was a good idea to give the turtles lines to say; unfortunately, each turtle only has about three. And they say them every single time they attack. Donatello may be the worst offender: "ANYONE FOR STICKBALL? I HAVE THE STICK—YOU BE THE BALL!" Odds are you'll be turning down the volume by halfway through the first level. Mercifully, the voice lines were significantly dialed down in the sequels.
One of Michelangelo's bosses, Nano Machine Ver. 3, has to be fought using aerial attacks. Which inevitably leads to an endless string of "EAT FEET EAT FEET EAT FEET EAT FEET" until the thing finally decides to go down.
Back in the day, people reportedly complained to the developers about having to listen to Leonardo go "SLICE N' DICE!" about once per second when fighting enemies.
As mentioned, Battle Nexus dialed back the voice lines significantly, but not quite enough, since Mikey going "Don't you know not to play with fire?" every other time you set off an explosive barrel or break open a crate still gets old pretty quick. The hoverboard and ship stages are probably the worst offenders, since your character goes "I'll take 'em all!" every time they grab a coin. And there's only a single sound file for that line. And the top reward for completing these stages requires you to collect every coin in a single run, so you will be hearing those voice lines a lot, as if resetting those stages over and over because of one missed coin wasn't annoying enough for those going after 100% Completion.
Hong Kong '97, an unlicensed Super Famicom game, only has one sound: a five-second loop of the Chinese pop song "I Love Beijing Tiananmen". It plays, without cease, even in the case of a Game Over (which is all too likely) and returning to the title screen.
Ruby charging her Heavy attack in RWBY: Grimm Eclipse. All characters yell while charging up their Heavy, but Ruby's sound is much louder and noticeable than the others, so hearing "Haaaaaaaaa!" repeated several times as a player is spamming that attack becomes extremely grating. Oh, and there's only one sound file for that attack.
You're going to get reaaal sick of Misa's voice quotes in Franchise/Gundam Breaker 3, as she simply will not stop narrating every single thing that happens. Yes, getting a chunk of your Gunpla blown off is cause for alarm, but when she shrills about it every single time it happens, sometimes within seconds of losing a piece the previous time, it erases any sympathy a player might have for her. Quite a few players actually let her get taken out just so she'll shut up already.
On a semi-related note, the sharp, rising 'ping' sound effect that comes when someone has charged a Shining Finger type attack. Especially if it's one of those missions where the game spams dozens of Nobel/Burning/Shining Gundams at you. This is because Finger-type attacks pretty reliably knock you down as well as blow the head off your mobile suit, costing you important abilities such as weapon targeting and enemy tracking.
In Cuphead, Rumor Honeybottoms makes a very annoying groan/whine at the start of her battle. She's That One Boss, so be prepared to hear that sound every time you retry the battle.
The shattering porcelain sound that plays when you take damage, and the "pop-WOOO" when you die. Given the kind of game this is, you'll be sick to death of those sounds eventually.
Ollie Bulb from "The Root Pack" makes an irritating crying sound when the cups shoot at him. Because of this, not shooting to him it will vanish and Horache Radiche appears in the third phase.
Yakuza 0 deliberately invokes this trope with the Mew Shoes item. Every single footstep you take is replaced by the sound of a cat's meow while you wear these shoes. Yes, even in the cutscenes, making this item a license to make your own narm. The game even informs you that the annoying sound that the shoes make will increase the rate of enemy encounters.
In Bayonetta, if you fail to complete a Chapter adequately, you will be awarded a Stone award, the lowest possible award available. This usually happens as a result of missing Verses (and the first time you play, you'll miss a lot of them due to being in hidden, counterintuitive, out-of-the-way spots that may require backtracking) or dying repeatedly. The Stone award depicts Enzo falling on his butt, and is accompanied by this voiced line which you will easily get sick of hearing if you don't pick up the game mechanics fast:
Enzo: Oh, what a day!
Your crew in Blast Corps love giving their two cents when you're trying to prevent the nuclear truck from detonating. "Try something else!" "Looks tricky...!" "You unaware of somethin'?" and your character's constant no!no!no!no! when you try and exit the vehicle in the wrong place
