Apocalypse may refer to:
- The trope known as The End of the World as We Know It (commonly referred to by the term "apocalypse"), and/or the index of tropes spawned from it, Apocalyptic Index, many of whose names include or derive from the word "apocalypse".
- Apocalypse, a Marvel Universe character first appearing in the 1986 run of X-Factor.
- The 1992 tabletop game, Werewolf: The Apocalypse, part of the Old World of Darkness series of roleplaying games.
- The 1997 video game, X-COM: Apocalypse, third in the X-COM series.
- The 1998 PlayStation shooter starring Bruce Willis, Apocalypse.
- The 1998 Christian eschatological film series, Apocalypse.
- The 2004 film, Resident Evil: Apocalypse, directed by Alexander Witt.
- The 2010 fanfic, Apocalypse WW 3.
- The 2010 animated film, Superman/Batman: Apocalypse, directed by Lauren Montgomery.
- The 2012 television series, Apocalypse, starring magician Derren Brown.
- The 2016 video game, Shin Megami Tensei IV: Apocalypse.
- The 2016 film, X-Men: Apocalypse, directed by Bryan Singer.
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