Each version of kryptonite has a different effect on kryptonians in Earth-27.
Kryptonite
- Green kryptonite immediately weakens their powers by sapping stored solar energy from the body. Prolonged exposure is fatal. It has no effect on half kryptonians during their childhood, but as they get older and reach adulthood it becomes increasingly toxic until it has the same effect on them as it does on full kryptonians. It has no effect on Bizarro or Doomsday, and it's known to trigger the meta gene in humans in certain circumstances.
- Red kryptonite, in both kryptonians and half kryptonians, immediately causes the loss of one's inhibitions. Prolonged exposure can cause compulsion to act out desires, with no regard for consequences. It temporarily enables the use of powers in younger half kryptonians that they haven't gotten yet. In Bizarro, it causes paranoia and more erratic behavior. As for humans, it's known to stimulate the metagene, granting them temporary powers when integrated into the body in some form, but once the red kryptonite is removed the powers still need to be reactivated in the normal way.
- Blue kryptonite not only depowers kryptonians and half kryptonians, but it also causes a euphoric sense of elation and the effect is known to stick around for a while after prolonged exposure, requiring significant solar recharge. As for Bizzarro; it has the same effect on him as green kryptonite has on normal kryptonians.
- Gold kryptonite heightens the potency of a kryptonian or half kryptonian's powers and can cause the development of new powers with prolonged exposure. Repeated exposure can build a tolerance, but can also cause cancer. As the product of gold kryptonite, Bizarro has developed a complete immunity to it, and it's theorized it can depower Doomsday. It's also fatal if it comes into contact with humans over an extended amount of time.
- Black kryptonite makes full blooded kryptonians incredibly paranoid and can make their powers become increasingly unstable. It has the same effect on Bizarro as red kryptonite does on normal and half kryptonians, and temporarily turns humans into kryptonians.
- White kryptonite is one of the hardest versions to find and in its pure state it has no known effect, however it can temporarily take on the color and abilities of other forms of kryptonite it is exposed to for prolonged periods of time.
- Finally pink kryptonite. In full blooded kryptonians, it acts as an aphrodisiac, while in half kryptonians it enhances their psychic abilities. Pink kryptonite was able to temporarily weaken Doomsday when he was first exposed to it, but it’s unknown if he's since developed immunity to it.
- Orange kryptonite is the rarest version of kryptonite, and it only affects Doomsday, humans, and some animals. It does accelerate Doomsday's evolution, it's mildly radioactive to humans, though it's unlikely to be fatal, and you can activate the metagenes in some animals, causing the development of meta-animal powers.
Other
- Nearly every supernatural being has at least one major weakness, just like how Kryptonians are weakened by kryptonite. Daimons and Divine Beings are weak to adamant, several demons and Fae are weak to Cold Iron, New Gods are weak to Radion, werebeasts are weak to silver and so on.
