It becomes more and more common with every new franchise that's added to Earth-27.
- Jennika Smith/Artemisia and Rob Smith/Rocksteady of the Teenage Mutant Ninja Turtles are half-siblings of Christopher Smith/Peacemaker, Giselle Smith/Gazelle and Samuel Smith through their shared father Jeffrey Smith, who's also the son of ''Wild Storm's serial killer Slaughterhouse Smith.
- Egon Spengler is the half-brother of Harry Spengler from Supernatural and Jillian Holtzman from the 2016 reboot, while Winston Zeddemore is the adoptive father of Ed and Maggie Zeddemore (also from Supernatural's Ghostfacers) and the uncle of Patty Tolan.
- Garrett Miller from Extreme Ghostbusters is the younger brother of Lisa Miller, Scott Pilgrim's childhood friend.
- The Winchester Family is very much related to the very extensive Blake Family, which includes characters from DC, Scooby-Doo and Watchmen.
- Missouri Moseley from Supernatural is the aunt of the odd superhero Stuart Moseley/Heckler.
- Pamela Barnes' father is Michael Barnes, who in Impact comics was the third hero known as The Shield. Her brother is Alan Barnes, who in DC comics was known as Brainstorm.
- Deaf hunter Eileen Leahy from Supernatural is the cousin of Arani Desai/Celsius of the Doom Patrol and niece of Willoughby Kipling.
- Damon Stewart/William Roque of The Losers is the presumed dead brother of John and Roselynn Stewart.
- Jonathan Crane/Scarecrow is a descendant of the Fable Ichabod Crane.
- Eric Morden/Mr. Nobody is the half-brother of Crowley from Supernatural, son of Rowena MacLeod and the uncle of Charaxes.
- Kala Dandekar from Sense8 is cousins with Chandi Gupta/Maya of the Justice League and Kiran Singh/Solstice of the Titans.
- The late father of Capheus Onyango is Matu Ba, who in the comics was the mentor of David Zavimbe/Batwing.
- Also from Sense8, Wolfgang Bogdanow is the nephew of Werner Zytle/King Vertigo and of Tashana Bogdanow/Lady Quark.
- Diego Morales, Will Gorski's partner, is the son of Crispus Allen and Rebecca Morales from IDW's Ghostbusters. He's also married to Isabella 'Dizzy' Cordova from 100 Bullets.
- Daniela 'Dani' Velasquez is the daughter of Tristessa Delicias/Scorpiana, sister of Vittoria Velasquez/The Wanderer and is the cousin of Ella Lopez from Lucifer.
- Elsa Grimston from Vertigo's The Witching Hour is the daughter of notorious tyrant and Ghostbusters' foe Vigo the Carpathian.
- Jay of Jay and Silent Bob is turned into Carol Ferris's brother.
- Rita Morgan, the wife of Dexter Morgan, is the sister of Brittany Brandon/Moonbow, making her aunt of Rita's children Astor and Cody.
- Dexter Morgan and his adoptive sister Debra are the cousins by adoption of Samara Morgan, who was adopted by their uncle Richard Morgan. Yes, the one from The Ring (2002).
