Pinky and the Brain are Heterosexual Life-Partners, but some episodes suggest they’re more than that. So much, even Rob Paulsen and Maurice LaMarche support the relationship.
- True, each of them had female love interests, but a DVD featurette even acknowledged that the show was about the "love" between the duo (they were probably talking about platonic love, but it's easy to misinterpret that). And in the episode "Brinky" the two inadvertently mixed their DNA together in a cloning machine, essentially having a child with each other.
- That whole episode exaggerated and pokes fun at the couple dynamic. They both fell into the family roles immediately and Romy addressed them as "my two dads". They went through all the cliche marriage problems of an after school special. At the end of it, Pinky asked Brain if they could have another. Why, even the episode title is a ship name: Brinky!
- There's also the episode "Pinky Suavo", where Pinky, through an accident with Brain's "Personalitron", becomes a charismatic, suave, romantic figure loved by everyone. And we mean everyone. Watch Brain's initial reaction to the new Pinky and just try to deny that he's suddenly developed at least a mancrush on him.
- For a brief moment in "You'll Never Eat Food Pellets In This Town Again", they sleep in the same bed.
- Pinky also often dresses up as Brain's wife, neither can live without the other (as seen in "This Old Mouse" and "A Pinky and the Brain Halloween"), Pinky's given up his soul for Brain and Brain's given up the world for Pinky, and in "Just Say Narf" there's a scene where he actually tries to seduce Brain on a bench. Honestly, the sheer amount of Ho Yay moments with these two is staggering.
- "I think so, Brain, but this time, you wear the tutu."
- The subtext between them gets even more paper-thin in the comics, with more questionable Are You Pondering What I'm Pondering? lines ("I think so, Brain, but this time I get to play the dishwasher repairman!"), Brain proclaiming that he could kiss Pinky out of gratitude (and Pinky being completely fine with the idea) and Pinky's reaction to Brain apparently severing their friendship is to attempt suicide.
