Aaahh!!! Real Monsters is a show about monsters trying to learn about scaring children, so, naturally, there are many instances of this occurring.
The Addams Family episode "Ask Granny" features a grotesquely detailed close-up of Granny Frump puckering up her lips when she beats a wrestler by scaring him with the offer of a kiss.
Amphibia: In "Temple Frogs", the Plantars' human disguises come off during a fight against a horde of Andrias' robots. After Anne realizes, the viewers are treated to a grotesquely detailed shot of the three: warts, webbed hands, and realistic frog eyes accounted for.
Used from time to time on Animaniacs such as Wakko's special salad he gives to the mobster in "Mobster Mash" and the plate of cockroaches and dung beetles Slappy gives Daniel Boone in "Frontier Slappy".
This trope is employed in a rare, non-comedic fashion (considering its use in an animated show) when Two-Face is unmasked after his surgery in Batman: The Animated Series.
This was used a couple of times in the short-lived John Kricfalusi helmed revival of Beany and Cecil a few examples included Dishonest John seeing a hideously deformed closeup of Cecil's face when he looks into his telescope, and as Dishonest John is talking to a mob boss who is clipping his fingernails we cut to a closeup of the infected and blackened fingernail.
In the Bunnicula episode "Catula" when Harold tells Chester that Bunnicula's bite won't turn him into a vampire because he chews on his foot in his sleep, which is then followed by a closeup of his swollen, pulsating, blister-covered foot.
"Bromeo and Juliet" has Mikey's fantasy of kissing Sophie end with him freaking out that he almost kissed Amanda, during which we are treated to a disturbingly detailed close-up of Amanda's puckered up lips.
"Bunsen Saves Christmas" features another disgusting close-up of Amanda Killman's lips when she tries to kiss Mikey under the mistletoe.
"Beastie Besties" has Amanda complain about her chronic dry eye syndrome, afterwards we get a shot focusing on her bloodshot eye.
"Wilda Beast" shows yet another grotesquely detailed shot of Amanda puckering up her lips near the end of the episode.
In the CatDog episode "Back to School", Mr. Sunshine gets one while giving Cat a Death Glare.
Clone High: "Blinded With Pseudoscience: Magnetic Distractions" shows a grotesque close-up of Scudworth's pierced ear being infected.
In one episode where the school is infested with pinkeye, it shows a closeup of the kid's eyes and the gunk oozing from underneath.
In another where Numbuh Five's sister Cree gets a zit she can't pop, she shows it to her and it shows a closeup of it swelling, pulsating, and oozing with pus, some of which is dripping on the ground.
The Daltons has one episode where Averell becomes a Transhuman and we get to see the lovely image of the internal anatomy of Averell's ear so that we can see the hearing-enhancing device scientists put inside him in action. The show usually portrays even potentially fatal (and actually fatal) injuries as Amusing Injuries.
Shows up in Daniel Tiger's Neighborhood of all places during "Miss Elaina Gets Hurt", wherein we get a rather gratuitous shot of Miss Elaina's scraped elbow.
In the Danny Phantom episode "Forever Phantom", we get a nice close-up of some teenage boy's pussing ingrown/cyst. Not surprising since this series is another one of Butch Hartman's works...
DC Super Hero Girls: "#SheMightBeGiant" shows a grotesquely detailed shot of Giganta's fingers when Bumblebee realizes that her shrunken state has enabled her to avoid getting crushed by Giganta's hands.
In the episode "Fantastic Boyage", Dexter goes into his pet dog to get rid of a disease.
Another episode has Dexter trying to improve his eyesight by giving himself laser-eye surgery. Everything goes Gone Horribly Right when he finds out his vision is TOO clear, his family's smallest physical flaws and imperfections are magnified a thousand fold by his vision. Through his eyes, his mother, father, and sister look like disgusting, malformed mutants.
Notably the episode "Samurai Quack", when Dodgers complains of his aching feet, followed by a close-up of his foot covered in blisters.
In another episode, Dodgers tells the Eager Young Space Cadet that he has perfect teeth, which then shows a close-up of his rotten, cavity-filled teeth.
Edd is looking at Ed's face through a microscope for clues and is rather disturbed by his uncleanliness.
Edd: Oh, my... Ed, there's this new invention called soap; have you heard of it?!
There was also the episode where Edd stuffs lint into his belly button.
The Fairly OddParents! frequently makes use of close-ups on disgustingly detailed things.
When Chip Skylark distresses over disappointing his fans by not showing up at the concert he's supposed to perform in "Boys in the Band", his appearance starts to deteriorate and we see shots focusing on his unkempt hair and his teeth becoming yellow and nasty.
There are unsettling zoom-ins on Cosmo, Wanda and Timmy's sleep deprivation-induced deformities in "Beddy Bye".
"Fairy Oddlympics" has a scene where Anti-Cosmo and Head Pixie dress up like women to deceive Jorgen. A shot from Jorgen's perspective consists of a grotesquely detailed close-up of Anti-Cosmo and Head Pixie's makeup-wearing faces.
"Timmy's Secret Wish" features disgusting zoom-ins on Timmy's liver sports after he discovers he has aged 50 years.
A disgusting close-up of Crocker's mother's face is shown in "The Wand That Got Away".
"Dadlantis" shows a zoom-in on the acne-ridden face of King Neptuna's son Gary.
"Chloe Rules!" has a disgusting close-up of Crocker's mother's foot.
"Ruled Out" gives us rather disgusting, detailed shots of Timmy's parents after they've spent an extended length of time neglecting basic hygiene.
"Miss Dimmsdale" has close-ups of Timmy's dad's exposed, hairy armpits while he's in a dress.
In the episode "Herpe, the Love Sore", we get disgusting close-ups of herpes sores from Brian and Chris.
In "Road to the North Pole" during the "Christmas Time is Killing Us" number, we briefly see a grotesque close-up of Santa’s face while he's looking in the mirror.
Santa: You may think I look great, but I'm 28!
In the sadly DVD-exclusive song "I've Got a Little List", Stewie holds up a magnifying glass to Bill O'Reilly's face while including his ineffective dermatologist among the list of people he wants to kill.
In "Girl, Internetted", Meg becomes an internet icon who sponsors and eats high-fat foods, eventually becoming obese and contracting Type 2 diabetes. This causes her to lose the use of her feet, which turn black and pus-covered. Later, when Peter attacks Cleveland with an ax in a parody of The Shining, there's a close-up of said feet.
The episode "Tooth or Scare" has a disgusting close-up of the wad of chewed gum that Fanboy and Chum Chum intend to use to keep Kyle's lost tooth in place so he won't suffer the wrath of the Wizard Tooth Fairy.
A grotesque close-up of Bus Lady Cram's disgusting foot is shown in "Field Trip of Horrors".
"Dentall Illness" shows sickening close-ups of Fanboy's decaying tooth.
"Champ of Chomp" shows a grotesque close-up of Chum Chum's bald spot.
"The Thief of Baghead" features one of these when Bender tries to get a good picture of the gang together at the aquarium, one of the shots he takes is a closeup of Professor Farnsworth's wrinkled warty face.
"Benderama" has a teenage giant picking up the Planet Express ship and holding it up to his pimply face.
Bender: Oh God, shield your eyes! It's like Edward James Olmos on IMAX!
"Three Hundred Big Boys" shows us close-ups of Professor Farnsworth's anti-aging stem cells wearing off, with his wrinkles and ear hairs coming back.
Miss Turtle gets one while giving Mickey a Death Glare in the House of Mouse episode "Mickey vs. Shelby".
Invader Zim is known for being one of the most disturbing cartoons on television. Part of the reason why this is is specifically because there is a tendency for them to show some rather... disturbing imagery. Special mention goes to Pustulio, Zim's giant hypnotic zit; the galactic equinox event that causes Zim to swell up to the size of an entire restaurant; Bloaty's Pizza Hog; and the rather disturbing shots of Dib's increasingly maimed body in "Bad, Bad Rubber Piggy".
In the Jelly Jamm episode "White Trainers", when Goomo shows the Queen his broken flip-flop, a close-up reveals there's mold growing on it. A few seconds later, when he's telling his flip-flop he'll miss it, he rubs it on his face and kisses it, which understandably disgusts Bello.
Jellystone!: In "Baby Shenanigans", there's a pretty nasty closeup of Snagglepuss' crow's feet.
Happens semi-regularly on Jimmy Two-Shoes. A good example is "The Racing Bug", which features a large number of these in shots of the Racing Fleas.
In the Looney Tunes Cartoons episode "Bathy Daffy", Porky wants to enter Daffy in a duck beauty contest but he hasn’t bathed in quite some time, at one point we see a closeup of his stinky feet covered in warts and blisters, toe jam, a piece of toilet paper attached to his heel, and long green toenails.
The Looney Tunes Show: In "Fish and Visitors", after Yosemite Sam takes a shower at Bugs's house, we get treated to lovely shots of a dirty toilet and a large wad of Sam's hair in the shower. Bugs reacts accordingly.
In Baby Looney Tunes, Taz gets one while giving Bugs a raspberry in "Things That Go Bugs in The Night". He gets another one when Daffy made him cry in "Mother's Day Madness".
Used in the cartoon "Ghoul Friend" with the close-ups of the zombie Goofy's rotting flesh, teeth, the fungus growing out of his body, and the slime dripping from his mouth.
Used again in the short "Goofy's First Love" when Goofy asks what is wrong with how he looks and we see a close-up of Goofy that exaggerates his buck teeth and has stink lines coming from his armpits.
Used again in "Couple's Sweaters" when Mickey suffers the effects of the dry, itchy sweater he's wearing, including chapped lips and rashy skin.
In the only two episodes of ¡Mucha Lucha! where they are shown, the Flea's rotten teeth get excruciating detail shown.
"A Bird in the Hoof" features a close-up of the sickly bird Philomena's blood-shot eyes.
"Green Isn't Your Color" has a brief shot of Rarity's pruny hoof.
In "Secret of My Excess", Spike claims that he wouldn't wash the cheek on which Rarity kissed him. When it cuts to one week later, it turns out he meant it.
In "Sick Day", we get a close-up of Pinkie Pie's hairy hoof when she holds up a book of instructions.
In "Whoof-Dunnit", Twilight gets one when she claims to Rarity she doesn't look good in a visor. She's right.
Used occasionally in The Powerpuff Girls, an example being "Sun Scream", when we get seven closeups of Blossom's pulsating sunburn skin while she's crawling across the bed.
Rocko's Modern Life didn't actually resort to this as often as other Grossout Shows at the time, but the early episode "Bedfellows" had a few in the scene where Rocko tries to get dry after a cold shower. He doesn't find a towel, but he is treated to Heffer's used deodorant stick and toothbrush.
Rolling with the Ronks!: "Flash a Smile" features several disgusting close-ups of Walter, Lula and the other Ronks' decaying teeth.
A lot of Rugrats episodes start with a weird closeup of something in this manner. One such example is "No Bones About It", which begins with what looks like a beating heart. However, it is really an extreme close-up of Spike's tongue as he is panting.
Sanjay and Craig used to use this at least once per episode, though Season 2 dialed it back a bit.
In the Sheep in the Big City episode "Beauty and the Bleats" after getting turned into a human by a genie in order to get into Lady Richington's Sheep-proof mansion, Sheep attempts to show Swanky who he really is by revealing his weird chicken birthmark, screaming sound and everything. Did we mention that it's rendered in LIVE ACTION?
In one Treehouse of Horror skit, Krusty's audience get to see his face in HD and he has wrinkly skin and bloodshot eyes.
Krusty: That's right, look at your hero!
In "New Kid on the Block", Bart declares he'll never wash his hand again when the girl who moves in next door spits on it as a prank. The scene fades to later, and we see Bart meant every word of that statement—his hand is now covered in dirt, grime, and chewing gum, and has an old band-aid stuck to one finger.
In the episode "Children of a Lesser Clod", we get a close-up of Homer's knee after he gets ACL surgery. The real kicker is when it starts rapidly healing over Ralph's hand.
Homer: It knows you're afraid.
During the song "Wouldn't It Be Adequate" from "My Fair Laddy", Groundskeeper Willie mentions his rotten teeth. Cue him holding a magnifying glass to his teeth, showing that they're coated with puke-green plaque.
Used once (and thank the Lord) in Sonic the Hedgehog (SatAM). The quote alone is enough to make viewers cringe: "Snively, what color is my heart?" For those wanting context: Robotnik is irritated at Snively. So, after giving this quote, he picks Snively up, opens his mouth inhumanly wide, and sticks Snively's head inside so that he can look straight down his throat, giving a perfect view of Robotnik's internal organs. Snively whimpers that he doesn't see a heart, after which Robotnik pulls out his stunned lackey and gives a smug "Exactly" in his trademark sinister, whispery voice.
"Nasty Patty" is a memorable example with the detailed shot of the disgusting patty SpongeBob and Mr. Krabs make under the belief that the health inspector at the Krusty Krab is the phony reported on the news who's only pretending to be a health inspector to get free food.
Yet another close-up on a disgusting Krabby Patty is used in "The Algae's Always Greener." When Plankton uses an invention to switch lives with Mr. Krabs, he puts Squidward on fry cook duty. As a dissatisfied customer shows him, the results aren't pleasant.
Plankton: What? It's just an ordinary Krabby Patt— OH MY GOODNESS! SQUIDWARD!
"To Love a Patty" has some particularly nauseating shots focusing on the rotting Krabby Patty SpongeBob forms a romantic relationship with. There's one near the end where THAT PATTY IS REVEALED TO HAVE MAGGOTS INSIDE.
In "Just One Bite", SpongeBob asks Squidward if he's sure he is immune to the Krabby Patty's tasty charms. Squidward responds by pointing to his own face and asking "Does this look unsure to you?" We then see a close-up of Squidward's face, wrinkly and scowling.
A shot focusing on the bags under Squidward's eyes appears when he complains that even the bags under his eyes have bags in "Fear of a Krabby Patty", complete with him putting on an extremely dour expression to match.
"What Ever Happened to SpongeBob?" was infamous for a scene where SpongeBob asks a bystander if there's something wrong with him and a shot of SpongeBob's face being grotesque and disturbing was shown. It's no wonder the guy then runs off screaming.
In the episode "Wormy", the titular caterpillar turns into a butterfly, and upon seeing the photorealistic closeup◊, Patrick and SpongeBob are so terrified they think it's a monster. (Fun fact: the close-up is of a horsefly, not a butterfly.) This one actually managed to get the episode banned in multiple countries due to scaring children.
"Mermaid Man and Barnacle Boy VI: The Movie" features very disturbing close-ups of Mermaid Man and Barnacle Boy after makeup artist Squidward is done preparing them for their SpongeBob-directed fan movie.
SpongeBob's face is given a close-up revealing zits, stubble and ghastly-looking teeth in "SpongeBob SquarePants vs. The Big One" when he tells Squidward that he shouldn't judge people based on how they look.
Squidward:[surprised] You're right.
SpongeBob's face is shown to be a wrinkled and stubbly mess in "SpongeBob, You're Fired" when he goes to Sandy after being laid off.
Squidward's nose gets a zoom-in revealing unsightly and sickening blemishes in "Code Yellow".
Gary's food in "Bunny Hunt" has a disembodied finger and ear inside of it.
"Kwarantined Krab" ends with nauseating gross-ups of all the main characters being extremely sick.
In the episode "Chille Tid", Steven notes that the other Crystal Gems look exhausted after spending all night combing the ocean for Lapis Lazuli and Jasper,. The camera suddenly cuts to Garnet, Amethyst, and Pearl looking unusually haggard, with messed-up hair, drool and age lines.
In the episode "Message Received", Peridot gets into a heated argument with Yellow Diamond. The argument escalates to the point where Peridot insults her to her face, prompting an insanely detailed look at what Yellow Diamond looks like when she's truly pissed◊.
Happens with Alice at points in Superjail!, with special attention paid to body hair, scabs, and mucus in different close-up shots. One example in the first episode even depicts lice crawling on her bared abs.
The Tak and the Power of Juju episode "This Bites" shows closeups of Jibolba's toothless gums and nose hairs as well as the Chief's navel.
The episode "Real Magic" shows a gross close-up of the waxy build-up in Beast Boy's ear when Robin does the old magic trick of finding a coin behind his ear.
"Salty Codgers" shows a couple of grotesque close-up shots of the people Mad Mod has made elderly by draining their youth.
One episode in Time Squad has the trio appear in the American Revolution to help Betsy Ross, who was going to make the US flag. Instead, the troops and Betsy were all acting like hippies. One of the guys says he's "made his own soap". Cue the camera closing in on his "soap" to show it's actually done from dirt among... other things.
Shows up in an episode of Tiny Toon Adventures with Ralph the guard (before Animaniacs aired) having a close-up of his hand. Doesn't sound gross, until you notice the knuckle hair and discoloration of his fingernails. Yeesh.
The episode "Dog Dish" features grossly detailed shots of the rash on Dudley's behind.
When Snaptrap makes the Chameleon turn into a toothpick in "Really Big Mission", we see a grotesque close-up of Snaptrap's teeth when he starts using the toothpick.
The Turbo F.A.S.T. episode "Zoo Lander" gives one of Skidmark and White Shadow's greasy, sleep-deprived faces after they spend 37 straight hours playing a video game.
In "Leaf It Alone", at the beginning when Bugs is raking leaves he mentions that his fingers hurt and he needs an extra pair of hands. We then see a closeup of his hands with his fingers covered in blisters.
In "The Game Is a Foot", when Bugs tries to convince the leprechaun as to why he can't have his foot, he tells him he has athlete's foot, ingrown toenails, fallen arches, and gout, which is then followed by a closeup of his disgusting-looking foot.
The cartoon short "Tales of Worm Paranoia" from the What A Cartoon! Show is full of these.
Yin Yang Yo! had one when Carl turned the twins ugly with a spell.
screaming sound and everything. Did we mention that it's rendered in LIVE ACTION?
