When Jonah Hill is messing around with the gun, James Franco is the only one not freaking out, instead simply asking for the gun back. That's because he's the only one who knows it's loaded with blanks.
When Jay tries to exorcise a possessed Jonah Hill using nothing but a makeshift cross and quoting The Exorcist, it works even to the Demon's surprise. That's because Jay believed it was gonna work, proving that Clap Your Hands If You Believe has its awesome moments.
The demon rape scene is played for laughs. But if you pay attentions to Jonah's scenes after that, he seems visibly shaken by the experience and actually reacts in a somewhat realistic way.
Danny McBride becomes the leader of a group of cannibals after getting kicked out of James Franco's house, but this is a world where good people were raptured and everyone else fell into sinkholes, so there is nothing left but empty houses full of food, like the one Jay and Craig ransack. Also, Danny makes Channing Tatum his personal gimp, despite the fact there are women among the cannibals. This could easily fall under Depraved Bisexual, but real life McBride, who film McBride is based on, is married with a wife.
As for the latter point, maybe he figured his wife was dead? Or maybe he just didn't care either way.
Also for the latter point, these are clearly fictionalised versions of the real people, so it's possible the fictional character's biography doesn't entirely match up with the real person's.
... So he can't be bisexual, because he has a wife?