Uncle Jalapeno, the Mexican, has a lowrider in the first America level.
The "Da" in Larry Da Vinci's name is always capitalized. At first, this seems like a mistake, as "da" is Italian for "of" and is not supposed to be capitalized. Until you realize: Larry Da Vinci has a British accent, and lives in a magical Dream Land, so he probably isn't actually Italian. "Da Vinci" is just his last name.
During Higginbotham’s crazy speech about what it was like to be infected, he claims he hallucinated his eyes turning into pies. While at first it seems like this was just another example of his Word-Salad Humor, it certainly explains why he was trying to lick his eyes.
Sure, it may be hilarious to find out that Newton's allergic to drowning, but it makes a lot more sense when you realize he's a lightbulb.