During the second ending, a scene has two strings, one purple and one pink, intertwining with one another before creating a ball that begins to divide itself. It's actually meant to serve as a representation of the union between Sasuke (purple) and Sakura (pink) and how they created Sarada. And the "ball" is actually a zygote, which is the creation of new life. See it here.
The Field Trip Arc takes place right after the 5 Kage Summit where Gaara and Naruto remind all the kages of the new generation's potential to surpass the previous one. The arc has Boruto's class involved in a problem with Hidden Mist shinobi, similar to one of Team 7's first big missions. The difference here is that unlike Team 7, Boruto's class have yet to graduate to being genin. Also, while Naruto and Team 7 had to deal with one member of the Seven Ninja Swordsmen of the Mist, Boruto's class have to deal with opponents holding all seven swords. Surpass the previous generation, indeed.
With the revelation of the purpose of Karma in the manga, Urashiki's apparent ineffectiveness against Boruto becomes far more understandable: He is protecting Momoshiki's new body and thus deliberately holding back. As he said to Toneri, he is not authorized to kill another member of his clan, and thus always sought to incapacitate or otherwise remove Boruto from the action with as little damage as he could manage. Indeed, when he finally snaps, he openly declares that he doesn't care if Boruto is Momoshiki's vessel; he's going to kill him, consequences be damned.
Koji Kashin being able to do Toad summons makes a lot more sense than it initially seems: Summon contracts are signed with the blood of the user, and since Koji is a clone of Jiraiya, he literally has the same blood as him, meaning that he can use the latter's contract from the get-go.
In the anime, Orochimaru claims to only care for Mitsuki as an experiment and nothing more. However, Log is able to tell that Oro does indeed care for Mitsuki as a person and his son. Why would Oro lie about how he views Mitsuki? While it’s definitely possible that Oro just hasn’t grown out of his habit for keeping secrets, considering how his Start of Darkness was the death of his parents, it also stands to reason that Oro is trying not to get too attached to Mitsuki because he fears he may have to experience the loss of yet another family member.
Naruto never having any spare time to be with his family after becoming Hokage might seem confusing at first when you consider that both the Third and Fifth Hokage were seen having time to relax every now and then. But then remember that Konoha went from basically a mid sized town to a sprawling urban city in the span of a couple of decades. While all the Hokages have been seen as Reasonable Authority Figures structurally the government of Konoha is a military dictatorship with one person making all the decisions even in the new era of peace they seem to have made no bureaucratic expansion to help run the day to day operations of the village even with all the expansions so of course the amount of paperwork for the Hokage is going to dramatically increase as well.
A big deal was made in Gaara Hiden about how Gaara needed to produce an heir to the Kazekage Clan's bloodline, because otherwise Shikadai, as Temari's son, would eventually have a claim to the Sixth Kazekage position despite being a Konoha citizen. While it turns out to have all been part of a plot for Tojuro to overthrow the Sand Siblings and take over Suna, it does establish that it is apparently expected that the Kazekages all come from the same bloodline... and by the time of Boruto, Kankuro and Gaara don't have biological children. *However* — Shinki has the Magnet Release, just like Gaara and the two previous Kazekages, and it's been established that combined-element natures are usually kekkei genkai and thus genetic. It stands to reason that even if Shinki is adopted, and thus isn't biologically Gaara's son, he probably is a blood relative of some sort, which would make him a candidate to eventually become the Sixth.
Another facet of why Naruto is so busy as Hokage gets revealed in the Family Day episodes. Namely, Konoha's culture was until recently rather ignorant of the idea of scheduled holidays. For ninja, days off were simply days they happened to not have a mission. The large influx of civilians during the post great war period meant a change in Konoha's culture though, as many started demanding that various official holidays be instituted. In a Heartwarming twist the ninja find they like the idea of scheduled holidays a great deal, and after getting tons of petitions and musing he likes the idea its implied Naruto proceeds to make an official holiday for every month so they can all get days off more often.
We see that Boruto's and Kawaki's Karma seals exhibit resonance, which accelerates the rate of Otsutsuki conversion. As they are hosts to two different Otsutsuki, what if this ensures that when both Otsutsuki manifest, they become partners right off the bat?
Kurama dying seemingly for good at first may seem like it breaks the lore of tailed beasts Resurrective Immortality. However, at the end of the previous series Sasuke certainly seemed to think it was possible to kill a tailed beast permanently as he twice states he intends to do just that (the first time when he asserts they will burn up along with ten tails, and the second when he states it as part of his plan for revolution once he is done using their chakra to undo the infinite tsukyomi). Further, the only time tailed beasts resurrecting is known to have happened is when the jinchuruki dies with the tailed beast inside them. This is not how Kurama died. As for baryon mode, there are many reasons even beyond "there was never a situation where they needed it" that could potentially explain why it hadn't been used before. Kurama may well have invented it, and thus no other tailed beast knew about it. It could even be only Kurama was physically powerful enough to use it. At the same time, the mysteries surrounding baryon mode allow for the potential for Kurama to resurrect should the story go that direct. Baryon mode had never been used before, so Kurama may well have had to guess at just what would happen to him after his "death." But as it stands, there are logical explanations for him staying dead, i.e. the previous series implying tailed beasts could die and stay dead, and the explanation that baryon mode changes Kurama's chakra into a entirely different kind of energy that is burned away, leaving nothing for him to resurrect with. He'd become a soul with no chakra left in it to link him to the living world, and thus stay in the afterlife.
Similarly, Kurama's death not killing Naruto, even though it's a known fact that removing Kurama would've killed him, makes more sense than it first appears. Namely, it makes perfect sense if we assume that the thing that kills the jinchuriki isn't the removal itself, but the damage to their chakra network. Long story short, for the tailed beast to be able to seamlessly share chakra with their host, their chakra networks need to be connected, yet distinct. They're not fully united, but they're connected enough that the host becomes used to having the tailed beast's massive chakra pool within it, and used to relying on the beast's chakra whenever they're in sync. And unfortunately, removing the biju doesn't carefully sever that connection first. Instead, it just rips the tailed beast out, damaging the host's chakra network, and maybe even pulling a few nodes with it; now, they not only have a lot less chakra than their body is accustomed to, possibly sending them into shock, there's also a big gaping hole in their network, and/or part of their network is outright missing. And since we know that using up too much chakra can be dangerous, from way back when Kakashi was teaching Sasuke the Chidori early on in Naruto, it starts to make a lot of sense; they just "used up" a ton of chakra, and also have to deal with internal injuries that may require healing. This also explains why putting the tailed beast back in can save the host's life despite the damage, with a bit of thought: Since the biju's chakra network is connected to the jinchuriki's network, the jinchuriki can use the biju's network as a substitute/backup network while their own network heals, and also isn't dangerously low on chakra anymore, taking a lot of stress off of their body. Similarly, giving them some of their tailed beast's chakra can save the host's life, even after the beast is removed, because it works like a blood transfusion to stabilise them after nearly bleeding out. Meanwhile, Kurama's natural death avoids all of that. Rather than being a sudden loss of chakra, his chakra is gradually used up, allowing Naruto's body to become accustomed to it so he won't go into shock. And depending on the specifics of how his death worked, his chakra network was either left behind in Naruto's body or safely disconnected without being ripped away, either of which prevented damage to Naruto's chakra network. It all adds up!
The reveal of the Karma casts both Orochimaru's Living Corpse Reincarnation and Cursed Seal techniques in a new light, respectively being a technique that allows the use of another person as a vessel, and one that leaves a mark on their body that can, under certain circumstances, allow the user to reincarnate through it. Either both could be the results of failed attempts to duplicate the Karma for Orochimaru's own use, or he has unknowingly discovered some of the basic mechanics of the Otsusuki clan's technique on his own, though not perfected them. The pale skin he shares with the clan could further hint at this connection.
.