Luke (Lou Taylor Pucci) is a 25-year-old autistic man living with his grandparents. After his grandmother Maggie dies, his grandfather Jonas (Kenneth Welsh) is placed in a nursing home, and Luke is forced to move in with relatives: his uncle Paul (Cary Elwes), Paul's wife Cindy (Kristin Bauer), and their teenage children Brad (Tyler Stentiford) and Megan (Mackenzie Munro). Paul and Cindy are angry and controlling and make Luke miserable, so he sets out to find a job and a girlfriend so he can be independent.
The Story of Luke contains examples of:
- Artistic License – Education: When Maggie was too sick to teach Luke, he was allowed to have the day off, causing him to graduate high school six years late. In real life, Luke would be legally entitled to an education, and if his family couldn't teach him, either they would have to find someone who could or he would be forced to go to school.
- Awful Wedded Life: Paul and Cindy are at each other's throats for most of the movie. When they aren't arguing, they're passive-aggressively sniping at each other.
- Basement-Dweller: At the beginning of the movie, Luke is unemployed and living with his grandparents.
- Correspondence Course: Luke got his cooking degree this way.
- Hates Being Touched: Luke stiffens or flinches whenever anyone tries to touch him.
- Homeschooled Kids: Luke was homeschooled after Maggie pulled him out of the special school because they were treating him like an idiot. Unfortunately, this means he didn't graduate high school until he was 24, because Maggie got sick and had a hard time teaching him.
- Literal-Minded: Luke gets confused when people use expressions.
- Love-Obstructing Parents: When Luke walks in on Brad kissing his girlfriend Charlene (Zoë Belkin), Brad asks him not to tell anyone.
- Male Gaze: When Luke sees his crush Maria (Sabryn Rock), the camera focuses on her breasts.
- Mean Boss: Luke's supervisor at Click&Easy, Zack (Seth Green), is very abrasive and constantly yells at and insults his employees. It turns out that he's autistic himself and is constantly in a bad mood from all the noise.
- Nepotism: The only reason Zack still has his job is because his father owns the company. Zack doesn't want the job, but his father thought it would build character, and he can't stay home with his mother all day because "I will die."
- Only Known by Their Nickname: Zack introduces himself as "Zack, never Zachary."
- Parental Abandonment: Luke's mother Sara (Lisa Ryder) left him at her parents' doorstep when he was four. She only visited him once, when he was six or seven. His father is absent as well; Sara never told anybody who he was.
- Porn Stash: Sam (Deshawne Williams), a store clerk, takes pity on Luke's ignorance of sex and gives him some dirty magazines to look at.
- Potty Failure: Jonas pees himself in Cindy's car, to her horror. She stops at the nearest store to buy every kind of air freshener they have in stock while Luke helps Jonas clean up in the bathroom.
- Sensory Overload: Luke is prone to this. At the beginning of the movie, he becomes so overwhelmed at Maggie's funeral that he screams.
- Sexless Marriage: Paul and Cindy haven't had sex in over a year.
- Sir Swears-a-Lot: Jonas is quite foul-mouthed.
- Supreme Chef: Luke is a talented cook. His favorite TV show is At Home with Arlene Williams, from which he has learned how to make 23 dishes. He teaches Cindy how to cook some of them, although she struggles to make anything edible without Luke's close supervision.
- Talk About the Weather: Zack tells Luke to do this. He starts mentioning the weather in almost every conversation.
- Who's Your Daddy?: Sara never told anyone who Luke's father was.
