Reynolds had been working in cartoons and anime movies since the early 1980s, and occasionally appeared as a screen actor in movies. He officially retired in 2004 after working on Ghost in the Shell: Stand Alone Complex, but returned briefly in 2009 to voice a government minister in Ghost in the Shell 2.0.
Notable voiceovers by Mike Reynolds include:
- Captain Mutiny in Power Rangers Lost Galaxy
- General Ivar in VR Troopers
- Gennai (old) in Digimon Adventure, Digimon: The Movie, and Digimon Adventure 02
- Govern in Brave Fencer Musashi
- Ies Bredell in Star Trek: 25th Anniversary and Judgment Rites
- James Lawrence in Ai no Wakakusa Monogatari
- Lord Orkham in Wolf's Rain
- Railspike in Transformers: Robots in Disguise
- Secretary of Defense in Zettai Muteki Raijin-Oh
- Takuma Hashizume in Rurouni Kenshin
- Walter and German Councilman in The Castle of Cagliostro (Streamline dub)
Live-action roles played include:
- A waiter and an angry Lakers fan in Curb Your Enthusiasm
- A landlord in Whos The Caboose
- Norman Borden in Tornado Run
- A monk in The Big Turnaround
