He appeared in:
- The Daily Show
- Cheap Seats as Bradley Wallace
- Arrested Development as James Carr
- Captain Underpants: The First Epic Movie as Mr. Krupp/Captain Underpants
- Chappaquiddick
- The Colbert Report
- The Office (US) as Andy Bernard
- Everyone's Hero
- Evan Almighty
- Walk Hard: The Dewey Cox Story
- Semi-Pro
- Confessions of a Shopaholic
- Childrens Hospital as Dr. Ed Helms
- Meet Dave as No. 2
- Harold & Kumar Escape from Guantanamo Bay
- American Dad!
- The Hangover as Stu
- Family Guy
- Night at the Museum: Battle of the Smithsonian
- Monsters vs. Aliens
- Jeff, Who Lives at Home
- Wilfred
- The Lorax (2012) as the Once-ler
- The Mindy Project as Dennis
- Ugly Americans
- We're the Millers as Brad Gurdlinger
- Saturday Night Live (hosted during the 2010-2011 season. Musical guest was Paul Simon)
- Brooklyn Nine-Nine
- Vacation as Rusty Griswold
- Mune: Guardian of the Moon (2017 English dub) as Spleen
- Tag
- Together Together as Matt
- Rutherford Falls as Nate Rutherford
- Ron's Gone Wrong as Graham Pudowski
- Fraggle Rock: Back to the Rock as Lyle Craggle
- Agent Elvis as TBA
- Family Switch as Bill Walker
Tropes:
- Beauty Inversion:
- Andy Bernard wears clean-cut garish outfits that make him look incredibly awkward in comparison to the other more practically dressed office staff. In real life Ed Helms is a much more relaxed dresser which gives him a greater appeal.
- Zigzagged in The Hangover. Ed Helms really does have a missing tooth which he only showed off here to emphasize Stu's Butt-Monkey vibe, but he also dresses like a massive nerd.
- The Cast Show Off: Plays the banjo and piano, and has played both in some of his TV and movie appearances. He also wrote and sang "Stu's Song" in The Hangover.
- The Danza: As Ed Carson in Evan Almighty.
- Large Ham: Most of his roles.
- Star-Making Role: Both The Office (US) and The Hangover trilogy gave significant push to his career.
